Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008].
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Ma, Murea, Snipes, Marinelarena, Krüger, Hicks, Langberg, Bostrom, Cooke, Suzuki, Babazono, Uzu, Tang, Mondal, Sharma, Kobes, Antinozzi, Davis, Das, Rasouli, Kern, Shores, Rudel, Blüher, Stumvoll et al.: "An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects. ..." in: PLoS ONE, Vol. 8, Issue 2, pp. e56193, (2013) (PubMed).
Reznick, Zong, Li, Morino, Moore, Yu, Liu, Dong, Mustard, Hawley, Befroy, Pypaert, Hardie, Young, Shulman: "Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis." in: Cell metabolism, Vol. 5, Issue 2, pp. 151-6, (2007) (PubMed).