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The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. 再加上，我们可以发serine/threonine Kinase 24 抗体 (89) 和 serine/threonine Kinase 24 蛋白 (13)和数多这个蛋白质的别的产品。
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CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations.
Mst3b, a neuron-specific homolog of the yeast kinase Ste20, is critical for axon outgrowth. Mst3b is activated in response to trophic factors, and suppressing its expression
High MST3 expression is associated with breast cancer.
This study demonistrated that MST3 kinase phosphorylates TAO1 (显示 TAOK2 ELISA试剂盒)/2 to enable Myosin Va (显示 MYO5A ELISA试剂盒) function in promoting spine synapse development.
This review notes that in the SOK1 and MST4 germinal center kinase III family of proteins, exon 1 encodes a 5' untranslated region, but this is not the case for MST3.
These data provide molecular understanding of the mechanism by which MO25 (显示 CAB39 ELISA试剂盒) isoforms regulates the activity of STE20 family protein kinases.
results show that a STRADalpha-rac1-PAK1 (显示 PAK1 ELISA试剂盒) pathway regulates cell polarity and invasion in LKB1 (显示 STK11 ELISA试剂盒)-null cells. It also suggests that while the function of LKB1 (显示 STK11 ELISA试剂盒) and STRADalpha undoubtedly overlap, they may also have mutually exclusive roles
mechanism of regulation of MST3
Striatin orchestrates the regulation of Mst3 by PP2A.
Mst3 is up-regulated and plays an important role in hypoxia-induced apoptosis of human trophoblasts.
five crystal structures of the catalytic domain of MST3 are presented, including a complex with ADP and manganese, a unique cofactor preferred by the enzyme, and a complex with adenine.
Proteolytic activation of Mst3 by caspases.
Mst3 phosphorylates RhoA (显示 RHOA ELISA试剂盒) at Ser26, thereby negatively regulating the activity of RhoA (显示 RHOA ELISA试剂盒) in neurons.
STK24 appears to suppress exocytosis by interacting and competing with UNC13D C2B domain for lipid binding, whereas CCM3 has dual roles in exocytosis regulation.
The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3\; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2\; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000
serine/threonine kinase 24 (STE20 homolog, yeast)
, serine/threonine-protein kinase 24
, STE20-like kinase 3
, STE20-like kinase MST3
, mammalian STE20-like protein kinase 3
, sterile 20-like kinase 3
, mammalian sterile twenty 3 kinase