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ARHGAP22 encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins.
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There is a significant association between single nucleotide polymorphism in the ARHGAP22 gene and diabetic retinopathy risk in a Han Chinese population
a weak complex between RhoGAP protein (显示 ARHGAP26 蛋白) ARHGAP22 and signal regulatory protein (显示 SIRPG 蛋白) 14-3-3 (显示 YWHAQ 蛋白) has 1 (显示 HAS1 蛋白):2 stoichiometry and a single peptide binding mode
The interaction of the IL1RAPL1 (显示 IL1RAPL1 蛋白) family of proteins with PTPdelta and RhoGAP2 reveals a pathophysiological mechanism of cognitive impairment associated with a novel type of trans-synaptic signaling.
Identification of RhoGAP22 as an Akt (显示 AKT1 蛋白)-dependent regulator of cell motility in response to insulin (显示 INS 蛋白)
We identified a genetic association for susceptibility to retinopathy in 5 novel chromosomal regions and PLXDC2 (显示 PLXDC2 蛋白) and ARHGAP22, the latter 2 of which are genes implicated in endothelial cell angiogenesis and increased capillary permeability.
a multifunctional regulatory protein (显示 TGFB1 蛋白) with Rac1-specific GTPase (显示 RACGAP1 蛋白)-activating activity; regulates transcriptional activity of the endothelin-1 (显示 EDN1 蛋白) promoter; involved in the signal transduction pathway regulating endothelial cell capillary tube formation
This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene.
Rho GTPase activating protein 22
, Rho GTPase activating protein 2
, Rho GTPase activating protein 25-like
, rho GTPase-activating protein 22-like
, rho GTPase activating protein 22
, rho GTPase-activating protein 22
, rho-type GTPase-activating protein 22