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The enzyme encoded by GGT1 catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. 再加上，我们可以发gamma Glutamyltransferase 1 抗体 (162) 和 gamma Glutamyltransferase 1 试剂盒 (62)和数多这个蛋白质的别的产品。
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gamma glutamyl transferase 1 (GGT1), the key enzyme of the gamma-glutamyl cycle, is expressed at approximately 100-fold lower levels in ChRCC compared with normal kidney, while no change in GGT1 expression was found in clear cell RCC (显示 XRCC1 蛋白) (ccRCC).
Data suggest that increased serum GGT level is independently associated with prevalence of hyperuricemia in middle-aged and elderly Chinese females.
elevated preoperative serum gamma-GGT was significantly associated with advanced tumor stage and aggressive tumor behaviors, and serum gamma-GGT can be considered as a prognostic factor for hepatocellular carcinoma patients after liver transplantation
Higher pre-treatment GGT serum levels were independently associated with unfavorable prognosis in women withu terine leiomyosarcoma (ULMS). Thus, GGT seems to be a useful novel biomarker in ULMS.
In a large Korean population-based study, elevated GGT levels were significantly associated with increased risk of atrial fibrillation.
The probe exhibits very high selectivity and sensitivity toward GGT activity from in vitro to in vivo and in clinical samples, which offers a promising tool for investigations of the GGT-overexpressing related biological process including tumor diagnosis and prognosis in living organisms.
both tumor GGT and serum GGT are poor prognostic factors in gastric cancer
The GPR could be used as a non-invasive marker to predict liver fibrosis and cirrhosis in CHB-NAFLD individuals.
This study demonstrated a positive association between serum GGT levels and LV diastolic dysfunction and LV hypertrophy in a large cohort of middle-aged men and women independent of potential confounders.
we found that serum exosomal GGT activity was significantly higher in prostate cancer (PC), patients than in benign prostatic hyperplasia (BPH) patients. In support of this finding, immunohistochemical analysis showed increased GGT1 expression in PC tissues compared with BPH tissues. Our results suggest that serum exosomal GGT activity could be a useful biomarker for PC
These findings elucidate a novel mechanism of inflammation-associated osteoclastogenesis, which involves TLR4 (显示 TLR4 蛋白) recognition of gamma-glutamyltranspeptidase and subsequent activation of MyD88 (显示 MYD88 蛋白)-dependent signaling.
the present study developed a liver-specific GGT-overexpressing mice model and found that GGT elevation in short term had no effects on glucose metabolism but could increase insulin (显示 INS 蛋白) sensitivity through enhancing the activity of insulin (显示 INS 蛋白) signaling pathway.
Statins can significantly decrease the expression of GGT in aortic atherosclerotic plaques of ApoE (显示 APOE 蛋白)-knockout mice.
Gamma-glutamyltransferase levels are an independent predictor of worsening kidney function and mortality in acute heart failure patients.
Disruption of the Mrds1/Ofcc1 gene elicits asymptomatic hyper-gamma-glutamyl-transpeptidasemia in mice.
Mutations in the Ggt1 gene are responsible for the phenotypes of dwg/dwg and dwg(Bayer)/dwg(Bayer) mice.
prooxidant reactions mediated by gamma-GT in turn regulate the levels of tyrosinase (显示 TYR 蛋白) in pigment cells.
GGT regulates osteoclast biology at least partly independently of sex steroids
GGT stimulates RANKL (显示 TNFSF11 蛋白) expression
GGT is implicated as being involved in diseases characterized by accelerated osteoclast development and bone destruction.
The enzyme encoded by this gene catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized and some of which may represent pseudogenes. This gene is classified as type I gamma-glutamyltransferase. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, gamma-glutamyltranspeptidase 1
, GGT 1
, gamma-glutamyl transpeptidase
, glutathione hydrolase 1
, leukotriene-C4 hydrolase
, glutamyl transpeptidase
, gamma glutamyl-transferase 1
, gamma-glutamyltransferase 2
, ggt 1
, gamma-glutamyltransferase 1 a
, Gamma-glutamyltranspeptidase 1
, gamma-glutamyltranspeptidase 1-like
, Gamma-glutamyltransferase 1