alpha-2-Macroglobulin 蛋白 (A2M)

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. 再加上,我们可以发alpha 2 Macroglobulin 抗体 (302)alpha 2 Macroglobulin 试剂盒 (88)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
A2M 2 P01023
A2M 24153 P06238
A2M 232345 Q6GQT1
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antibodies-online.cn销售最多的alpha 2 Macroglobulin 蛋白

Showing 10 out of 40 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Baculovirus infected Insect Cells His tag 50 μg Log in to see 20至21个工作日
大肠杆菌(E. Coli) His tag 100 μg Log in to see 15至18个工作日
大肠杆菌(E. Coli) 大鼠 His tag 100 μg Log in to see 15至18个工作日
大肠杆菌(E. Coli) 小鼠 His tag 100 μg Log in to see 15至18个工作日
大肠杆菌(E. Coli) 野猪 His tag 100 μg Log in to see 15至18个工作日
Human 非结合性 Gel Scan of Alpha 2 Macroglobulin, Human Plasma  This information is representative of the product ART prepares, but is not lot specific. 1 mg Log in to see 3至4个工作日
Human 非结合性 1 mg Log in to see 2至3个工作日
小麦胚 GST tag 10 μg Log in to see 11至12个工作日

A2M 蛋白 by Origin and Source

Origin 在表达 标记
Human , , , , , ,
, ,
Rat (Rattus) ,

Mouse (Murine) ,

引用最多的alpha 2 Macroglobulin 蛋白

  1. Human alpha 2 Macroglobulin Protein expressed in Human - ABIN935646 : Rahman, Jeng, Singh, Coughlin, Essani, McFadden: Interaction of human TNF and beta2-microglobulin with Tanapox virus-encoded TNF inhibitor, TPV-2L. in Virology 2009 (PubMed)

  2. Human alpha 2 Macroglobulin Protein expressed in Human - ABIN491569 : Komissarov, Florova, Azghani, Karandashova, Kurdowska, Idell: Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids. in American journal of physiology. Lung cellular and molecular physiology 2013 (PubMed)

  3. Human alpha 2 Macroglobulin Protein expressed in Human - ABIN3119641 : Ksiazek, Mizgalska, Enghild, Scavenius, Thogersen, Potempa: Miropin, a novel bacterial serpin from the periodontopathogen Tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop. in The Journal of biological chemistry 2015 (PubMed)

更多alpha-2-Macroglobulin (A2M)互动伙伴

Human alpha-2-Macroglobulin (A2M) interaction partners

  1. The blood coagulation pathway may be a key regulatory network pathway contributing to the allergic inflammatory response in AR patients. A2M, which is regulated by STAT3 (显示 STAT3 蛋白), may be an important protein in the pathogenesis of allergic rhinitis in AR patients.

  2. Proteomics study showed a strong association of FN1 (显示 FN1 蛋白), A2M, C4BPA (显示 C4BPA 蛋白) and CFB (显示 CFB 蛋白) in molecular subtypes of breast cancer, in which, C4BPA (显示 C4BPA 蛋白) and A2M demonstrated a potent signature in blood plasma and tissue samples of Luminal-B (LB (显示 HLA-DPB1 蛋白)) and Triple-negative (TN)subtypes in BC patients, respectively.

  3. BBB disruption is present in ACS (显示 PLA2G15 蛋白), and elevated levels of IL-6 (显示 IL6 蛋白) and C3 in CSF (显示 CSF2 蛋白) in diffuse NPSLE

  4. Case Reports: inflammatory myofibroblastic tumors of the lung containing a chimeric A2M-ALK gene categorized as a specific type of inflammatory myofibroblastic tumor that develops exclusively in neonates and infants.

  5. The plasma level of alpha2M was found positively correlated, while HCII (显示 SERPIND1 蛋白) level was negatively correlated with higher vulnerability of carotid plaques. Both proteins were efficient in differentiating stable and vulnerable carotid plaques. These provide potential new targets for the research of carotid plaque vulnerability. Plasma alpha2M and HCII (显示 SERPIND1 蛋白) may be potential biomarkers for evaluation of the vulnerability of carotid ...

  6. Stabilizers during pasteurization improved alpha-2-macroglobulin (alpha2-M) activity by more than 300% points compared with the unstabilized control.

  7. Data show that low that low globulin (GLB (显示 DCXR 蛋白)) levels were significantly associated with favorable survival, and low ALB (显示 ALB 蛋白) levels were associated with a significantly worse survival .

  8. This work demonstrates that alpha2M*/CS-GRP78 (显示 HSPA5 蛋白) acts as an upstream regulator of the PDK1 (显示 PDK1 蛋白)/PLK1 signaling axis to modulate c-MYC (显示 MYC 蛋白) transcription and its target genes, suggesting a therapeutic strategy for targeting c-MYC (显示 MYC 蛋白)-associated malignant progression.

  9. Meta-analysis. Our data indicate that the rs669 (A/G) polymorphisms in A2M gene are associated with increased risk in Parkinson disease.

  10. These data demonstrate that alpha2M* and LRP1 (显示 LRP1 蛋白) modulate the BKCachannel in human myometrium and that BKCaand its immunomodulatory interacting partners regulate Ca(2 (显示 CA2 蛋白)+)dynamics in hMSMCs during pregnancy.

Mouse (Murine) alpha-2-Macroglobulin (A2M) interaction partners

  1. To investigate the pharmacokinetics (PKs) and pharmacodynamics (PDs (显示 SLC26A4 蛋白)) for ION-353382, an antisense oligonucleotide (ASO) targeting scavenger receptor class B type I (SRB1) mRNA, using alpha-2-macroglobulin (A2M), murinoglobulin double-knockout (DKO), and wild-type mice

  2. A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin (显示 HAMP 蛋白) remains labile and available to down-regulate Fpn1 (显示 SLC40A1 蛋白).

  3. Data show that MAA-A2M adduct formation abrogated the binding of A2M bait region with TGF-beta1, trypsin, and elastase.

  4. MMP9 (显示 MMP9 蛋白) production promoted by the alpha(2)M*/LRP1 (显示 LRP1 蛋白) interaction required the activation of both MAPK (显示 MAPK1 蛋白)-ERK1/2 and NF-kappaB (显示 NFKB1 蛋白) signaling pathways.

  5. Alpha2 macroglobulin requires cyclic amp (显示 TMPRSS5 蛋白) and signal transduction for cell growth

  6. Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin.

  7. the 4622-base pair cDNA encodes a protein of 1473 AA with >70% sequence identity and all typical domains of other A2M-family members in humans and rodents

  8. Data describe the role of the PI3-kinase (显示 PIK3CA 蛋白)/PDK (显示 PDK2 蛋白)/Akt (显示 AKT1 蛋白)/p70s6k (显示 RPS6KB1 蛋白) signaling cascade in alpha 2-macroglobulin-induced cellular proliferation and the role of CREB (显示 CREB1 蛋白) in these events.

  9. review the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy.

  10. the inhibition of proteases on the surface of microorganisms by an ancestral alpha2M-like thiol ester protein may generate "arrays" of oligomannose glycans to which MBL or other lectins can bind

Pig (Porcine) alpha-2-Macroglobulin (A2M) interaction partners

  1. Data suggest that alpha(2)-macroglobulin from serum could significantly compensate for the impaired cumulus expansion of oocytes matured in serum.

Cow (Bovine) alpha-2-Macroglobulin (A2M) interaction partners

  1. Mutations in the promoter region and the 3'-untranslated region of the A2M gene are involved in the mastitis susceptibility in dairy cows.

  2. We report here for the first time the direct isolation of Spp24 (显示 SPP2 蛋白) covalently bound to alpha2-macroglobulins as a core complex (Spp24 (显示 SPP2 蛋白)-alpha2M) from bovine calf serum.

  3. Exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis.

  4. These results suggest the possible involvement of cathepsin E (显示 CTSE 蛋白) in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system.

  5. Alpha2-macroglobulin is a substrate and an endogenous inhibitor for ADAMTS-4 (显示 ADAMTS4 蛋白) and ADAMTS-5 (显示 ADAMTS5 蛋白)

  6. Amounts of alpha(2)-M receptor in granulosa cells were strongly inversely associated with concentrations of estradiol in dominant and subordinate follicles.

蛋白简介alpha 2 Macroglobulin (A2M)


Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.

Gene names and symbols associated with alpha-2-Macroglobulin 蛋白 (A2M)

  • alpha-2-macroglobulin (A2M)
  • alpha-2-macroglobulin (A2m)
  • alpha-2-macroglobulin (LOC477699)
  • pregnancy-zone protein L homeolog (pzp.L)
  • alpha-2-macroglobulin (AZL_c00450)
  • ovostatin-like (LOC100224071)
  • alpha-2-macroglobulin (LOC100349077)
  • ovostatin (OVST)
  • alpha-2-macroglobulin (a2m)
  • alpha-2-macroglobulin (LOC100061656)
  • alpha-2-macroglobulin (LOC100090399)
  • alpha-2-macroglobulin S homeolog (a2m.S)
  • alpha-2-macroglobulin (LOC100469973)
  • alpha-2-macroglobulin (LOC100595735)
  • pregnancy zone protein (PZP)
  • alpha-2-macroglobulin (LOC100353095)
  • alpha-2-macroglobulin (LOC101122940)
  • alpha-2-macroglobulin (LOC101801552)
  • alpha-2-macroglobulin-like (LOC100911545)
  • A2M 蛋白
  • A2m1 蛋白
  • A2maa 蛋白
  • A2MAC1 蛋白
  • a2mb 蛋白
  • A2MD 蛋白
  • A2mp 蛋白
  • Alpha-2-M 蛋白
  • cpamd5 蛋白
  • endod 蛋白
  • endodermin 蛋白
  • fwp007 蛋白
  • LOC733429 蛋白
  • LOC100224071 蛋白
  • Mam 蛋白
  • s863-7 蛋白

Protein level used designations for alpha-2-Macroglobulin 蛋白 (A2M)

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 , alpha-2-M , alpha-2-macroglobulin-P , alpha-2-macroglobulin , alpha-2-macroglobulin-like , ovomacroglobulin, ovostatin , alpha 2m , endodermin , Alpha2-macroglobulin , alpha-2-macroglobulin b , pregnancy zone protein

2 Homo sapiens
24153 Rattus norvegicus
232345 Mus musculus
403166 Sus scrofa
418251 Gallus gallus
465372 Pan troglodytes
477699 Canis lupus familiaris
513856 Bos taurus
716834 Macaca mulatta
733429 Xenopus laevis
8794592 Azospirillum sp. B510
100173946 Pongo abelii
100224071 Taeniopygia guttata
100349077 Oryctolagus cuniculus
100390764 Callithrix jacchus
396151 Gallus gallus
619586 Xenopus (Silurana) tropicalis
100061656 Equus caballus
100090399 Ornithorhynchus anatinus
100158443 Xenopus laevis
100469973 Ailuropoda melanoleuca
100595735 Nomascus leucogenys
100153288 Sus scrofa
100353095 Oryctolagus cuniculus
101122940 Ovis aries
101801552 Anas platyrhynchos
100911545 Rattus norvegicus
101794357 Anas platyrhynchos
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