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alphaKGDHC encodes one subunit of the 2-oxoglutarate dehydrogenase complex. 再加上，我们可以发alpha Ketoglutarate Dehydrogenase 抗体 (54) 和 alpha Ketoglutarate Dehydrogenase 试剂盒 (32)和数多这个蛋白质的别的产品。
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oxoglutarate dehydrogenase (OGDH) and lipoic acid synthase (LIAS (显示 LIAS 蛋白)), which when mutated stabilize HIF1alpha (显示 HIF1A 蛋白) in a non-hydroxylated form.
Tissue-specific expression of OGDH splice variants may thus provide a mechanism that tunes the control of the enzyme to the specialized metabolic and signalling needs of individual cell types
Acute inhibition of alpha-ketoglutarate dehydrogenase produces effects on calcium opposite to those in Alzheimer's disease (AD), while the chronic or long-term inhibition of alpha-KGDHC mimicked the AD-related changes in calcium.
2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability is regulated by the RING finger ubiquitin ligase Siah
Reduction in the E2k (显示 DLST 蛋白) subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity.
We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase and induces histone modifications in an ACL (显示 APOC4 蛋白)-dependent manner
Taken together, our results indicate that the redox sensing and ROS (显示 ROS1 蛋白) forming properties of Pdh (显示 PDP 蛋白) and Ogdh are linked to S-glutathionylation
pre-incubation of permeabilized liver mitochondria from mouse depleted of GSH showed an approximately ~3.5-fold increase in Ogdh-mediated O2(-)/H2O2 production that was matched by a significant decrease in NADH formation which could be reversed by Grx2 (显示 GRX2 蛋白). Taken together, our results demonstrate GSH and GSSG modulate ROS (显示 ROS1 蛋白) production by Ogdh through S-glutathionylation of different subunits
The nitration degree of alpha-OGDH for diabetic mouse is higher than that for control mouse, indicating that alpha-OGDH of the diabetic mouse suffered from more intense oxidative damage.
Alpha-ketoglutarate dehydrogenase is a primary site of ROS (显示 ROS1 蛋白) production in normally functioning mitochondria.
In the postnatal mouse brain,high mRNA levels of d1401/Ogdh were observed in the olfactory bulb, hippocampus, cerebellum, and pons.
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
2-oxoglutarate dehydrogenase, mitochondrial
, 2-oxoglutarate dehydrogenase complex component E1
, oxoglutarate decarboxylase
, oxoglutarate dehydrogenase (succinyl-transferring)
, 2-oxoglutarate dehydrogenase E1 component, mitochondrial
, alpha-ketoglutarate dehydrogenase
, oxoglutarate dehydrogenase (lipoamide)