alpha Ketoglutarate Dehydrogenase 蛋白 (alphaKGDHC)

alphaKGDHC encodes one subunit of the 2-oxoglutarate dehydrogenase complex. 再加上,我们可以发alpha Ketoglutarate Dehydrogenase 抗体 (54)alpha Ketoglutarate Dehydrogenase 试剂盒 (32)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
alphaKGDHC 4967 Q02218
alphaKGDHC 18293 Q60597
大鼠 alphaKGDHC alphaKGDHC 360975 Q5XI78
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10至12个工作日
大肠杆菌(E. Coli) His tag Validation with Western Blot 50 μg Log in to see 10至12个工作日
酵母菌 Golden Syrian Hamster His tag   1 mg Log in to see 60至71个工作日
大肠杆菌(E. Coli) T7 tag,His tag 100 μg Log in to see 15至18个工作日

alphaKGDHC 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine)

更多alpha Ketoglutarate Dehydrogenase (alphaKGDHC)互动伙伴

Human alpha Ketoglutarate Dehydrogenase (alphaKGDHC) interaction partners

  1. oxoglutarate dehydrogenase (OGDH) and lipoic acid synthase (LIAS (显示 LIAS 蛋白)), which when mutated stabilize HIF1alpha (显示 HIF1A 蛋白) in a non-hydroxylated form.

  2. Tissue-specific expression of OGDH splice variants may thus provide a mechanism that tunes the control of the enzyme to the specialized metabolic and signalling needs of individual cell types

  3. Acute inhibition of alpha-ketoglutarate dehydrogenase produces effects on calcium opposite to those in Alzheimer's disease (AD), while the chronic or long-term inhibition of alpha-KGDHC mimicked the AD-related changes in calcium.

  4. 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability is regulated by the RING finger ubiquitin ligase Siah

  5. Reduction in the E2k (显示 DLST 蛋白) subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity.

Mouse (Murine) alpha Ketoglutarate Dehydrogenase (alphaKGDHC) interaction partners

  1. We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase and induces histone modifications in an ACL (显示 APOC4 蛋白)-dependent manner

  2. Taken together, our results indicate that the redox sensing and ROS (显示 ROS1 蛋白) forming properties of Pdh (显示 PDP 蛋白) and Ogdh are linked to S-glutathionylation

  3. pre-incubation of permeabilized liver mitochondria from mouse depleted of GSH showed an approximately ~3.5-fold increase in Ogdh-mediated O2(-)/H2O2 production that was matched by a significant decrease in NADH formation which could be reversed by Grx2 (显示 GRX2 蛋白). Taken together, our results demonstrate GSH and GSSG modulate ROS (显示 ROS1 蛋白) production by Ogdh through S-glutathionylation of different subunits

  4. The nitration degree of alpha-OGDH for diabetic mouse is higher than that for control mouse, indicating that alpha-OGDH of the diabetic mouse suffered from more intense oxidative damage.

  5. Alpha-ketoglutarate dehydrogenase is a primary site of ROS (显示 ROS1 蛋白) production in normally functioning mitochondria.

  6. In the postnatal mouse brain,high mRNA levels of d1401/Ogdh were observed in the olfactory bulb, hippocampus, cerebellum, and pons.

蛋白简介alpha Ketoglutarate Dehydrogenase (alphaKGDHC)


This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with alphaKGDHC

  • oxoglutarate dehydrogenase (OGDH)
  • oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (Ogdh)
  • oxoglutarate dehydrogenase (Ogdh)
  • 2210403E04Rik 蛋白
  • 2210412K19Rik 蛋白
  • AA409584 蛋白
  • AKGDH 蛋白
  • d1401 蛋白
  • E1k 蛋白
  • mKIAA4192 蛋白
  • OGDC 蛋白

Protein level used designations for alphaKGDHC

2-oxoglutarate dehydrogenase, mitochondrial , 2-oxoglutarate dehydrogenase complex component E1 , OGDC-E1 , oxoglutarate decarboxylase , oxoglutarate dehydrogenase (succinyl-transferring) , 2-oxoglutarate dehydrogenase E1 component, mitochondrial , alpha-ketoglutarate dehydrogenase , oxoglutarate dehydrogenase (lipoamide)

426429 Gallus gallus
4967 Homo sapiens
475499 Canis lupus familiaris
534599 Bos taurus
18293 Mus musculus
360975 Rattus norvegicus
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