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Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. 再加上，我们可以发aHSP 试剂盒 (26) 和 aHSP 蛋白 (16)和数多这个蛋白质的别的产品。
Showing 10 out of 52 products:
Human Monoclonal aHSP Primary Antibody for ELISA, WB - ABIN526641
Wang, Fang, Guo, Ren, Zhang: Transgenic human alpha-hemoglobin stabilizing protein could partially relieve betaIVS-2-654-thalassemia syndrome in model mice. in Human gene therapy 2010
Mouse (Murine) Polyclonal aHSP Primary Antibody for FM, IHC (fp) - ABIN1043695
Nasimuzzaman, Khandros, Wang, Kong, Zhao, Weiss, Rivella, Weiss, Persons: Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia. in American journal of hematology 2010
In the presence of free alpha subunits and H2O2, both HbA (显示 SCN2A 抗体) and HbE (显示 HBe1 抗体) showed bCys93 oxidation which increased with higher H2O2 concentrations. In the presence of Alpha-hemoglobin stabilizing protein (AHSP)Cys93 oxidation was substantially reduced in both proteins.in the presence of excess free alpha-subunit (显示 POLG 抗体) and under the same oxidative conditions, these events are substantially increased for HbE (显示 HBe1 抗体) compared to HbA (显示 SCN2A 抗体)
Findings indicate that alpha-hemoglobin-stabilizing protein (AHSP) expression is a biomarker of hemoglobin (显示 HBB 抗体) H (HbH (显示 HBA1 抗体)) disease severity and infer an important role of AHSP in modulating the pathophysiology of this disease.
AHSP is predominantly expressed in erythroid precursors in bone marrow biopsy specimens from patients with hematologic malignancies.
AHSP expression was higher in patients with sickle cell anemia versus thalassemia, with no significant difference between BTM and BTI. Expression was higher in patients with NTDT and on hydroxyurea therapy.
In maturing RBC (显示 CACNA1C 抗体) progenitors AHSP bind to free alpha-globin (显示 HBA1 抗体) chains to increase the HbA (显示 SCN2A 抗体) production. (Review)
analysis showed binding of STAT3 (显示 STAT3 抗体) to AHSP promoter and binding was significantly augmented with IL6 (显示 IL6 抗体) stimulation and upon alpha-globin (显示 HBA1 抗体) overexpression
The relationship between AHSP gene expression, disease severity, and the beta/alpha globin (显示 HBA1 抗体) mRNA ratio was studied among different homozygote beta-thalassemia patients.
alpha-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy (显示 GCG 抗体)-alpha-hemoglobin and weakens the iron-oxygen bond.
alpha-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of alpha-subunits of human HbA (显示 SCN2A 抗体) with hydrogen peroxide.
AHSP acts as a molecular chaperone (显示 HSP90AA1 抗体) by rapidly binding and stabilizing met-alpha hemichrome folding intermediates
role of alpha-hemoglobin stabilizing protein in hemoglobin assembly
Endogenous AHSP is not limiting for alpha-globin (显示 HBA-A1 抗体) detoxification in beta-thalassemic mice.
activin A (显示 INHBA 抗体) does not appear to affect the exocrine or endocrine components of the pancreas, but promotes differentiation of pancreatic tissue into intestine via a Shh (显示 SHH 抗体)-dependent mechanism
Loss of AHSP impairs erythropoiesis and exacerbates beta-thalassemia.
These results support the hypothesis that EKLF (显示 KLF1 抗体) acts as a transcription factor and a chromatin modulator for the AHSP and beta-globin (显示 HBB 抗体) genes and indicate that EKLF (显示 KLF1 抗体) may play similar roles for other erythroid genes.
developmental stage- and differentiation state-specific regulation of the nuclear transport of EKLF (显示 KLF1 抗体) might be one of the steps necessary for the switch-on of the mammalian adult beta globin (显示 HBB 抗体) gene transcription
AHSP also acts as a molecular chaperone to stabilize nascent alpha-globin for hemoglobin A assembly
The expression of AHSP in a subclone of murine erythroleukemia cells in relationship to prion protein (显示 PRNP 抗体) on the cell surface is reported.
Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation (By similarity).
alpha hemoglobin stabilizing protein
, erythroid associated factor
, alpha hemoglobin stabilising protein
, alpha-hemoglobin-stabilizing protein
, erythroid differentiation associated factor
, erythroid differentiation-related factor
, erythroid-associated factor