anti-alpha Hemoglobin Stabilizing Protein (aHSP) 抗体

Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. 再加上,我们可以发aHSP 试剂盒 (27)aHSP 蛋白 (16)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
aHSP 51327 Q9NZD4
aHSP 170812 Q9CY02
aHSP 293522  
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antibodies-online.cn销售最多的anti-aHSP 抗体

Showing 10 out of 54 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
小鼠 非结合性 FM, IHC (fp), ELISA, WB   100 μL Log in to see 5至7个工作日
大鼠 非结合性 ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Rat Liver Tissue; Lane2: Mouse Liver Tissue. 100 μg Log in to see 13至16个工作日
非结合性 IHC, IHC (p), WB Immunohistochemistry-Paraffin: ERAF Antibody [NBP1-84008] - Staining of human bone marrow shows strong cytoplasmic and nuclear positivity in subsets of hematopoietic cells. Western Blot: ERAF Antibody  - Lane 1: Marker  250, 130, 95, 72, 55, 36, 28, 17, 10 Lane 2: Negative control (vector only transfected HEK293T lysate) Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY413883) 0.1 mL Log in to see 10至13个工作日
小鼠 非结合性 ICC, IHC, WB Used in DAB staining on fromalin fixed paraffin- embedded stomach tissue 100 μg Log in to see 15至18个工作日
非结合性 ELISA, IHC, IHC (p), WB 100 μL Log in to see 11至14个工作日
非结合性 ICC, IHC, WB Western Blot; Sample: Rat Liver lysate; Primary Ab: 1µg/ml Rabbit Anti-Human aHSP Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg Log in to see 15至18个工作日
非结合性 WB Western blot analysis of AHSP expression in mouse liver (A), rat liver (B) whole cell lysates. 200 μL Log in to see 13至14个工作日
大鼠 非结合性 IF/ICC, IHC, IP, WB Western blot analysis of (1) Rat Liver Tissue and (2) Mouse Liver Tissue. Western blot analysis of recombinant Rat aHSP. 100 μg Log in to see 11至18个工作日
小鼠 非结合性 WB Western blot analysis of extracts of various cell lines, using AHSP antibody (ABIN5973863) at 1/1000 dilution. 100 μL Log in to see 11至16个工作日
小鼠 非结合性 ELISA, WB Detection limit for recombinant GST tagged ERAF is 0.03 ng/ml as a capture antibody. Western Blot detection against Immunogen (36.96 KDa) . 100 μg Log in to see 11至12个工作日

引用最多的anti-aHSP 抗体

  1. Human Monoclonal aHSP Primary Antibody for ELISA, WB - ABIN526641 : Wang, Fang, Guo, Ren, Zhang: Transgenic human alpha-hemoglobin stabilizing protein could partially relieve betaIVS-2-654-thalassemia syndrome in model mice. in Human gene therapy 2010 (PubMed)

  2. Mouse (Murine) Polyclonal aHSP Primary Antibody for FM, IHC (fp) - ABIN1043695 : Nasimuzzaman, Khandros, Wang, Kong, Zhao, Weiss, Rivella, Weiss, Persons: Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia. in American journal of hematology 2010 (PubMed)


Human alpha Hemoglobin Stabilizing Protein (aHSP) interaction partners

  1. In the presence of free alpha subunits and H2O2, both HbA and HbE showed bCys93 oxidation which increased with higher H2O2 concentrations. In the presence of Alpha-hemoglobin stabilizing protein (AHSP)Cys93 oxidation was substantially reduced in both the presence of excess free alpha-subunit and under the same oxidative conditions, these events are substantially increased for HbE compared to HbA

  2. Findings indicate that alpha-hemoglobin-stabilizing protein (AHSP) expression is a biomarker of hemoglobin H (HbH) disease severity and infer an important role of AHSP in modulating the pathophysiology of this disease.

  3. AHSP is predominantly expressed in erythroid precursors in bone marrow biopsy specimens from patients with hematologic malignancies.

  4. AHSP expression was higher in patients with sickle cell anemia versus thalassemia, with no significant difference between BTM and BTI. Expression was higher in patients with NTDT and on hydroxyurea therapy.

  5. In maturing RBC progenitors AHSP bind to free alpha-globin chains to increase the HbA production. (Review)

  6. analysis showed binding of STAT3 to AHSP promoter and binding was significantly augmented with IL6 stimulation and upon alpha-globin overexpression

  7. The relationship between AHSP gene expression, disease severity, and the beta/alpha globin mRNA ratio was studied among different homozygote beta-thalassemia patients.

  8. alpha-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-alpha-hemoglobin and weakens the iron-oxygen bond.

  9. alpha-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of alpha-subunits of human HbA with hydrogen peroxide.

  10. AHSP acts as a molecular chaperone by rapidly binding and stabilizing met-alpha hemichrome folding intermediates

  11. AHSP could be a secondary compensatory mechanism in red blood cells to counterbalance the excess of alpha-globin chains in HbE/beta-thalassaemia individuals.

  12. NF-E2 may play an important role in AHSP gene regulation, providing new insights into the molecular mechanisms underlying the erythroid-specific expression of AHSP as well as new possibilities for beta-thalassemia treatment

  13. No significant association has been found between specific AHSP alleles or haplotypes and the disease severity of beta-thalassemia. Our study suggested that AHSP is not a significant genetic modifier of beta-thalassemia in southern China.

  14. Overexpression of human AHSP & 2 mutant versions with AA substitutions confering 3- or 13-fold higher affinity for alpha-globin had no major effects on hematologic parameters in beta-thalassemic mice.

  15. analysis of the action of a human mutant, AHSPV56G, of alpha-hemoglobin stabilizing protein (AHSP)

  16. Studies indicate that the interaction of alpha-Hb with AHSP involves surfaces normally employed in binding to beta-Hb.

  17. Different mechanisms may be responsible for the amount of abnormal Hb recovered, such as a highly unstable alpha chain or an impaired formation of the complex AHSP/alpha-Hb or a modification of the alphabeta dimer formation.

  18. An abundant erythroid protein that stabilizes free alpha-haemoglobin.

  19. determination as a predominantly alpha-helical globular protein with a somewhat asymmetric shape

  20. progesterone, corticotropin-releasing factor, and activin A have roles in paracrine regulation of endometrial function [review]

Mouse (Murine) alpha Hemoglobin Stabilizing Protein (aHSP) interaction partners

  1. role of alpha-hemoglobin stabilizing protein in hemoglobin assembly

  2. Endogenous AHSP is not limiting for alpha-globin detoxification in beta-thalassemic mice.

  3. An abundant erythroid protein that stabilizes free alpha-haemoglobin.

  4. activin A does not appear to affect the exocrine or endocrine components of the pancreas, but promotes differentiation of pancreatic tissue into intestine via a Shh-dependent mechanism

  5. Loss of AHSP impairs erythropoiesis and exacerbates beta-thalassemia.

  6. These results support the hypothesis that EKLF acts as a transcription factor and a chromatin modulator for the AHSP and beta-globin genes and indicate that EKLF may play similar roles for other erythroid genes.

  7. developmental stage- and differentiation state-specific regulation of the nuclear transport of EKLF might be one of the steps necessary for the switch-on of the mammalian adult beta globin gene transcription

  8. AHSP also acts as a molecular chaperone to stabilize nascent alpha-globin for hemoglobin A assembly

  9. The expression of AHSP in a subclone of murine erythroleukemia cells in relationship to prion protein on the cell surface is reported.

aHSP 抗原简介


Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation (By similarity).

Gene names and symbols associated with aHSP

  • alpha hemoglobin stabilizing protein (AHSP) 抗体
  • alpha hemoglobin stabilizing protein (Ahsp) 抗体
  • alpha-hemoglobin-stabilizing protein-like (LOC100620111) 抗体
  • AHSP 抗体
  • EDRF 抗体
  • Eraf 抗体

Protein level used designations for aHSP

alpha hemoglobin stabilizing protein , erythroid associated factor , alpha hemoglobin stabilising protein , alpha-hemoglobin-stabilizing protein , erythroid differentiation associated factor , erythroid differentiation-related factor , erythroid-associated factor

454073 Pan troglodytes
714392 Macaca mulatta
100127218 Ovis aries
100340962 Oryctolagus cuniculus
51327 Homo sapiens
170812 Mus musculus
338381 Bos taurus
293522 Rattus norvegicus
100712877 Cavia porcellus
100620111 Sus scrofa
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