alpha 1 Microglobulin/bikunin (AMBP) ELISA试剂盒

Human alpha 1 Microglobulin/bikunin (AMBP) interaction partners

1. AMBP mRNA and protein levels were found to be significantly lower in the oral squamous cell carcinoma (OSCC) tumors and cell lines. The underexpression of AMBP was significantly associated with a high metastatic potential to cervical lymph nodes and a poor overall survival. AMBP was suggested to play an important role in the invasive and migratory ability of OSCC cells.

2. There were significantly higher serum concentrations of fetal hemoglobin and alpha1-microglobulin and significantly lower first trimester serum concentrations of hemopexin in patients who later developed preeclampsia.

3. Prophylactic UTI maintains the endothelial barrier function, increases VE-cadherin expression, and inhibits the phosphorylation of VE-cadherin at Tyr658 under inflammatory conditions

4. Data suggest that Mg2+ or Mn2+ (but not Ca2+) induce a conformational change in inter-alpha-inhibitor (ITIH1 and ITIH2) and a bikunin/chondroitin sulfate-dependent increase in thermodynamic stability; bikunin binds adjacent to the two heavy chains.

5. Data indicate that two heme groups can be bound simultaneously at separate sites in the antioxidant alpha1-microglobulin.

6. results indicate a reduced UTI level in CSF of MS and NMO patients. The levels were associated with the severity of the two demyelinating diseases during relapse

7. Proximal tubular dysfunction, indicated by urine alpha1-microglobulin, was independently associated with kidney function decline in HIV-infected and uninfected women and mortality risk among HIV-infected women.

8. placental alpha microglobulin-1 is a sensitive and specific test to assess rupture of membranes in patients with an equivocal diagnosis based on simple tests

9. Heavy chain transfer by tumor necrosis factor-stimulated gene 6 to the bikunin proteoglycan.

10. Decreased bikunin mRNA level in renal cells might be associated with poor prognosis of renal carcinoma.

11. The antioxidative protection of cells and collagen by A1M is totally dependent on its C34 amino acid residue.

12. Label-free quantitative comparison of DN urinary exosomes vs control group and SRM further validation, resulted in the discovery of a panel of three proteins (AMBP, MLL3 and VDAC1) which changes in DN.

13. The high level of serum AMBP could predict the poor response of the AGC patients.

14. In pre-term pregnant women with intact membranes, placental alpha-microglobulin-1 in cervicovaginal fluid test rates are more positive in cases of uterine contraction.

15. our findings suggest that urine bikunin level, as well as proteinuria, could represent a useful parameter for monitoring renal function in those patients that do not present any symptoms of renal insufficiency.

16. Determined is the first structure of human alpha-1-microglobulin with heavy electron density of the chromophore.

17. Sulfation of the bikunin chondroitin sulfate chain determines heavy chain.hyaluronan complex formation

18. High urine alpha-1-microglobulin is associated with interstitial fibrosis and tubular atrophy plus inflammation.

19. High urine alpha-1-microglobulin is associated with ischemic acute tubular necrosis than other causes of acute kidney injury.

20. Report prognostic value of urinary alpha 1-macroglobulin in idiopathic membranous nephropathy.

Xenopus laevis alpha 1 Microglobulin/bikunin (AMBP) interaction partners

1. Study isolated the Xenopus AMBP cDNA and characterized the peptide structure and developmental regulation of the gene expression. The results showed that Xenopus AMBP gene is repressed through the direct action of thyroid hormone upon liver parenchymal cells at the metamorphic climax stage.

Pig (Porcine) alpha 1 Microglobulin/bikunin (AMBP) interaction partners

1. The aim of this research was to screen polymorphism and to perform association study of porcine AMBP, GC and PPP1R3B genes with meat quality traits.

Mouse (Murine) alpha 1 Microglobulin/bikunin (AMBP) interaction partners

1. Loss of Ambp led to increased anxiety-like behavior, reduced social and exploratory activity.

2. Loss of bikunin expression is associated with Embryos failing to Initiate Midgut Rotation.

3. In this review, the use of genetically targeted mice selectively lacking UTI provides evidence of a therapeutic option for experimental endotoxin-related inflammatory disorders such as acute lung injury and acute liver injury.

4. expression of the AMBP gene transcript and its two protein products, alpha(1)-microglobulin and bikunin, in embryogenesis

5. UTI inhibited LPS-induced production of TNF-alpha by inhibiting activation of the extracellular signal-regulated protein kinases 1/2-Egr-1 pathway in monocytes, which might at least partly contribute to reduction of hypotension

6. UTI protects against systemic inflammatory response and subsequent organ injury induced by bacterial endotoxin.

7. results indicate that endogenous UTI is protective against acute lung injury induced by bacterial endotoxin, at least partly, via the antioxidative properties

8. increased sensitivity of Bik-/- mice to lung metastasis in vivo is due to a lack of circulating proteins of the inter-alpha inhibitor family, especially bikunin

9. UTI reduces NF-kappaB activation and downregulates the expression of its related mediators, followed by the inhibition of neutrophil aggregation and infiltration in hepatic ischemia reperfusion injury

10. Report impaired liver regeneration with humoral and genetic disturbances in urinary trypsin inhibitor-deficient mice.

11. UTI protects against severe liver injury and subsequent coagulatory disturbance which was mediated, at least partly, through the suppression of TNF-alpha production along with its antiprotease activity.