alpha 1, 4-Galactosyltransferase 蛋白 (A4GALT)

The protein encoded by A4GALT catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. 再加上,我们可以发A4GALT 抗体 (68)A4GALT 试剂盒 (2)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
A4GALT 53947 Q9NPC4
A4GALT 63888 Q9JI93
A4GALT 239559 Q67BJ4
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Showing 7 out of 13 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells 小鼠 rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50至55个工作日
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
小麦胚 GST tag 10 μg Log in to see 11至12个工作日
大肠杆菌(E. Coli) 非结合性 SDS-PAGE analysis of Human a4GALT Protein. 100 μg Log in to see 11至18个工作日
大肠杆菌(E. Coli) 小鼠 非结合性 SDS-PAGE analysis of Mouse a4GALT Protein. 100 μg Log in to see 11至18个工作日
大肠杆菌(E. Coli) 大鼠 非结合性 SDS-PAGE analysis of Rat a4GALT Protein. 100 μg Log in to see 11至18个工作日
酵母菌 Pongo pygmaeus His tag   1 mg Log in to see 60至71个工作日

A4GALT 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, , ,
Rat (Rattus)

Mouse (Murine) ,
, ,

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Human alpha 1, 4-Galactosyltransferase (A4GALT) interaction partners

  1. These data indicate that RUNX1 regulates A4GALT and thereby the expression of clinically important glycosphingolipids implicated in blood group incompatibility and host-pathogen interactions.

  2. The differential binding of transcription factor early growth response 1 to the SNP rs5751348 genomic region with the different genotypes in the A4GALT gene leads to differential activation of P(1) -A4GALT and P(2) -A4GALT expression.

  3. A4GALT SNPs spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group system

  4. Study reports a novel mutation in the A4GALT gene that was responsible for a p phenotype in a Chinese individual.

  5. amino acid residue at position 211 of Gb3/CD77 synthase is critical for specificity and activity of the enzyme involved in formation of P(k), P1 and NOR antigens. Altogether, this approach affords a new insight into the mechanism of action of the human Gb3/CD77 synthase.

  6. This is the first direct biochemical evidence that Gb3/CD77 synthase is able to synthesize two different glycosphingolipid antigens: P(k) and P1, and when p.Q211E substitution is present, the NOR antigen is also synthesized.

  7. Mutation in the A4GALT gene is associated with rare p phenotype in P1Pk blood group system.

  8. The results of this investigation demonstrate a consistent association of A4GALT SNPs rs2143918 and rs5751348 with the P1/P2 phenotypes and suggest that SNP rs5751348 may lead to allelic variations in A4GALT gene expression

  9. these data elucidate a new explanation underlying the p phenotype, implicating the deleted regions of A4GALT as crucial for P1 and P(k) synthesis, possibly due to loss of binding sites for erythroid transcription factors.

  10. P1-decorated PSGL-1/mIgG2b bound with high avidity to both Stx1 and Stx2, and as such constitutes a potential therapeutic inhibitor of these toxins.

  11. several P1PK-null alleles were identified.

  12. Results suggest that the C631G mutation alters the acceptor specificity of Gb3/CD77 synthase, rendering it able to catalyze synthesis of the Gal(alpha1-4)Gal and Gal(alpha1-4)GalNAc moieties.

  13. Increased globotriaosylceramide levels are detected in a transgenic mouse expressing human alpha1,4-galactosyltransferase in a mouse model for treating Fabry disease.

  14. 2 Taiwanese individuals with p phenotype were homozygous for a & 428. No expression of P(k) & no enzyme activity were observed in cells transfected with the mutant construct.

  15. Total urinary protein isoforms of globotriaosylceramide were used to identify Fabry disease in women.

  16. Data showed that GRINA-C was associated with Gb3 synthase, and may demonstrate a new type of posttranscriptional regulation of glycosyltransferases.

  17. of A4GALT mRNA in cultured human bone marrow cells revealed novel transcripts containing only the noncoding exon 1 and a sequence (here termed exon 2a) from intron 1.

  18. We established by quantitative real-time PCR that both fresh colonic epithelial sections and HCT-8 cells express Gb3 synthase mRNA and the alternate Shiga toxin receptor globotetraosylceramide.

  19. expression in megakaryoblastic leukemia cells

  20. The P blood group phenotype is due to several disctint nonfunctional alleles of A4GALT without any predominant allele.

Mouse (Murine) alpha 1, 4-Galactosyltransferase (A4GALT) interaction partners

  1. Gb3 and Gb4 synthase are responsible for the expression of globo-series glycolipids

  2. Gb3/CD77 synthase has a role in synthesis of globo-series glycosphingolipids and sensitivity to verotoxins

  3. Verification of the function of Gb3 in the pathogenesis of hemolytic-uremic syndrome as the cellular receptor responsible for cytotoxicity caused by verotoxin (VT) elaborated by Shigella and certain strains of E.coli.



The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.

Gene names and symbols associated with A4GALT

  • alpha 1,4-galactosyltransferase (P blood group) (A4GALT)
  • alpha 1,4-galactosyltransferase (A4galt)
  • alpha 1,4-galactosyltransferase (A4GALT)
  • alpha 1,4-galactosyltransferase (P blood group) (A4galt)
  • A4GALT1 蛋白
  • A14GALT 蛋白
  • Gb3 蛋白
  • Gb3S 蛋白
  • P(k) 蛋白
  • P1 蛋白
  • P1PK 蛋白
  • PK 蛋白

Protein level used designations for A4GALT

CD77 synthase , GB3 synthase , P blood group (P one antigen) , P(k) antigen synthase , P1/Pk synthase , UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase , alpha-1,4-N-acetylglucosaminyltransferase , alpha4Gal-T1 , globotriaosylceramide synthase , lactosylceramide 4-alpha-galactosyltransferase , Gb3 synthase , alpha-1,4-galactosyltransferase , Gb3/CD77 synthase , alpha 1,4-galactosyltransferase (globotriaosylceramide synthase) , alpha 1,4-galactosyltransferase (globotriaosylceramide synthase, P blood group) , gb3 synthase

53947 Homo sapiens
63888 Rattus norvegicus
239559 Mus musculus
418223 Gallus gallus
481222 Canis lupus familiaris
470230 Pan troglodytes
100721247 Cavia porcellus
618369 Bos taurus
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