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The protein encoded by A4GALT catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. 再加上，我们可以发A4GALT 抗体 (69) 和 A4GALT 试剂盒 (2)和数多这个蛋白质的别的产品。
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A4GALT SNPs spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group (显示 DARC 蛋白) system
Study reports a novel mutation in the A4GALT gene that was responsible for a p phenotype in a Chinese individual.
Mutation in the A4GALT gene is associated with rare p phenotype in P1Pk blood group (显示 DARC 蛋白) system.
The results of this investigation demonstrate a consistent association of A4GALT SNPs rs2143918 and rs5751348 with the P1/P2 phenotypes and suggest that SNP rs5751348 may lead to allelic variations in A4GALT gene expression
these data elucidate a new explanation underlying the p phenotype, implicating the deleted regions of A4GALT as crucial for P1 and P(k) synthesis, possibly due to loss of binding sites for erythroid transcription factors.
P1-decorated PSGL-1 (显示 SELPLG 蛋白)/mIgG2b bound with high avidity to both Stx1 (显示 STX1A 蛋白) and Stx2 (显示 STX2 蛋白), and as such constitutes a potential therapeutic inhibitor of these toxins.
Results suggest that the C631G mutation alters the acceptor specificity of Gb3/CD77 synthase, rendering it able to catalyze synthesis of the Gal (显示 GAL 蛋白)(alpha1-4)Gal (显示 GAL 蛋白) and Gal (显示 GAL 蛋白)(alpha1-4)GalNAc moieties.
Increased globotriaosylceramide levels are detected in a transgenic mouse expressing human alpha1,4-galactosyltransferase (显示 GGTA1 蛋白) in a mouse model for treating Fabry disease.
Data showed that GRINA-C was associated with Gb3 synthase, and may demonstrate a new type of posttranscriptional regulation of glycosyltransferases.
of A4GALT mRNA in cultured human bone marrow cells revealed novel transcripts containing only the noncoding exon 1 and a sequence (here termed exon 2a) from intron 1.
The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.
, GB3 synthase
, P blood group (P one antigen)
, P(k) antigen synthase
, P1/Pk synthase
, UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
, globotriaosylceramide synthase
, lactosylceramide 4-alpha-galactosyltransferase
, Gb3 synthase
, Gb3/CD77 synthase
, alpha 1,4-galactosyltransferase (globotriaosylceramide synthase)
, alpha 1,4-galactosyltransferase (globotriaosylceramide synthase, P blood group)
, gb3 synthase