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Zmpste24 encodes a member of the peptidase M48A family. 再加上，我们可以发Zinc Metalloproteinase, Ste24 抗体 (128) 和 Zinc Metalloproteinase, Ste24 蛋白 (7)和数多这个蛋白质的别的产品。
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ZMPSTE24 is a downstream effector of IFITM3 (显示 IFITM3 ELISA试剂盒) and is important for interferon (显示 IFNA ELISA试剂盒)-induced transmembrane antiviral activity.
ZMPSTE24 is an important element for innate host defense against a broad spectrum of pathogenic viruses.
This case demonstrates that accumulation of prelamin A, independent of the loss of function of ZMPSTE24 metallopeptidase (显示 ECEL1 ELISA试剂盒) that catalyzes processing of prelamin A, can cause a progeroid disorder and that a cell biology assay could be used in precision medicine to identify a potential therapy.
used a fluorogenic assay of the activity of purified ZMPSTE24 to demonstrate that HIV protease inhibitors directly inhibit the human enzyme in a manner indicative of a competitive mechanism
the present study suggests that inhibition of ZMPSTE24 by both mutational and expressional pathways might together play a role in tumorigenesis of colorectal cancer and gastric cancer harboring microsatellite instability phenotype.
results establish that the substrate profile of Ste24p is broader than anticipated, being more similar to that of the M16A protease family than that of the Rce1p CAAX protease with which it has been functionally associated
ZMPSTE24 downregulation is a major contributor in VSMC dysfunctions resulting from LMNA (显示 LMNA ELISA试剂盒) mutations or PI treatments that could translate in early atherosclerosis at the clinical level.
Here, we report on a familial c.50delA (p.Lys17Serfs*21) mutation of the ZMPSTE24 gene, causing RD in two siblings.
complete loss-of-function of ZMPSTE24 leads to RD, whereas other less severe phenotypes are associated with at least one haploinsufficient allele.
miR (显示 MLXIP ELISA试剂盒)-141-3p, which is overexpressed during senescence as a result of epigenetic regulation, is able to decrease ZMPSTE24 expression levels, and leads to an upregulation of prelamin A in human mesenchymal stem cells.
these findings suggest that downregulated miR3425p is involved in regulating cell proliferation and cell cycles in Zmpste24/ MEFs by suppressing GAS2 in vitro.
we identified the abnormal lamin A (显示 LMNA ELISA试剂盒) (prelamin A), accompanied by a down-regulation of a lamin A (显示 LMNA ELISA试剂盒) processing enzyme (Zmpste24) in the kidney of the GMF (显示 GMFB ELISA试剂盒) transgenic mice
In Zmpste24(-/-) mice, histone H4 was hypoacetylated at a lysine 16 residue (H4K16), and this defect was attributed to the reduced association of a histone acetyltransferase (显示 HAT ELISA试剂盒), Mof (显示 KAT8 ELISA试剂盒), to the nuclear matrix.
Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.
Zmpste24 has a role in processing of prelamin A and lack of Zmpste24 results in a brittle bone phenotype
the progeria-like phenotypes caused by the lack of Zmpste24 in knockout mice is eliminated by heterozygosity for Lmna (显示 LMNA ELISA试剂盒)
Lack of functional Zmpste24, a metalloproteinase responsible for the maturation of prelamin A, also results in progeroid phenotypes in mice
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
, zinc metallopeptidase (STE24 homolog)
, zinc metallopeptidase STE24 homolog
, zinc metalloproteinase STE24 homolog
, CAAX prenyl protease 1 homolog
, STE24 endopeptidase
, zinc metalloproteinase
, zinc metallopeptidase STE24
, CAAX prenyl protease 1 homolog-like
, farnesylated proteins-converting enzyme 1
, prenyl protein-specific endoprotease 1
, zinc metalloproteinase Ste24 homolog
, zinc metallopeptidase, STE24 homolog
, zinc metalloproteinase, STE24 homolog
, farnesylated-proteins converting enzyme 1
, zinc metalloproteinase (STE24 homolog, yeast)