anti-Zinc Finger Protein ZIC 1 (ZIC1) 抗体

ZIC1 encodes a member of the ZIC family of C2H2-type zinc finger proteins. 再加上,我们可以发ZIC1 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
ZIC1 7545 Q15915
ZIC1 64618  
ZIC1 22771 P46684
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Showing 10 out of 68 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-ZIC1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  ACHN cell lysate 100 μL Log in to see 2至3个工作日
非结合性 EIA, WB ZIC1 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35 µg/lane). This demonstrates the ZIC1 antibody detected the ZIC1 protein (arrow). 0.4 mL Log in to see 6至8个工作日
小鼠 非结合性 ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.08 KDa) . Dilution: 1:500~1000 Detection limit for recombinant GST tagged ZIC1 is approximately 0.3ng/ml as a capture antibody. 100 μg Log in to see 8至11个工作日
非结合性 ICC, IHC (fro), IF, IHC (p), IHC, WB Western Blot: Zic1 Antibody [ABIN153383] - WB analysis of Zic1 in overexpression lysate. 0.1 mL Log in to see 7至9个工作日
非结合性 ICC, IF, IHC, IHC (p), WB Western Blot: ZIC1 Antibody  - Analysis in control (vector only transfected HEK293T lysate) and zIC1 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells). Immunocytochemistry/Immunofluorescence: ZIC1 Antibody  - Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm. 0.1 mL Log in to see 10至13个工作日
Bat 非结合性 WB 50 μg Log in to see 11至14个工作日
非结合性 WB ZIC1 Antibody (N-term)  western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ZIC1 antibody detected the ZIC1 protein (arrow). All lanes : Anti-ZIC1 Antibody (N-term) at 1:2000 dilution Lane 1: Jurkat whole cell lysates Lane 2: SH-SY5Y whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 48 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:2000 400 μL Log in to see 10至11个工作日
非结合性 IF, IHC (p), WB Immunohistochemistry (IHC) analyzes of Zic1/2/3 antibody in paraffin-embedded human brain tissue. Western blot (WB) analysis of Zic1/2/3 antibody in extracts from Jurkat cells. 0.1 mg Log in to see 6至8个工作日
非结合性 FACS, IHC, IHC (p), WB Immunohistochemistry-Paraffin: ZIC1 Antibody (JA31-60)  - Analysis of paraffin-embedded mouse brain tissue using anti-Zic1 antibody. Counter stained with hematoxylin. Immunohistochemistry-Paraffin: ZIC1 Antibody (JA31-60)  - Analysis of paraffin-embedded rat brain tissue using anti-Zic1 antibody. Counter stained with hematoxylin. 100 μL Log in to see 34 Days
小鼠 非结合性 ELISA, WB ZIC1 monoclonal antibody (M06), clone 4D2. Western Blot analysis of ZIC1 expression in HeLa. Western Blot detection against Immunogen (34.14 KDa) . 100 μg Log in to see 11至12个工作日

引用最多的anti-ZIC1 抗体

  1. Human Polyclonal ZIC1 Primary Antibody for ICC, IHC (fro) - ABIN153383 : Lipchina, Elkabetz, Hafner, Sheridan, Mihailovic, Tuschl, Sander, Studer, Betel: Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response. in Genes & development 2011 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal ZIC1 Primary Antibody for ICC, IF - ABIN4366890 : Simões-Costa, McKeown, Tan-Cabugao, Sauka-Spengler, Bronner: Dynamic and differential regulation of stem cell factor FoxD3 in the neural crest is Encrypted in the genome. in PLoS genetics 2013 (PubMed)


Human Zinc Finger Protein ZIC 1 (ZIC1) interaction partners

  1. this severe brain malformation indicates that premature closure of sutures can be independent of the abnormal brain development in subjects with pathogenic variants in ZIC1.

  2. Study demonstrate that ZIC1 plays a tumor suppressive role in breast cancer, by targeting surviving, significantly downregulating its expression.

  3. Two proposed mechanisms for Zic-mediated cerebellar developmental control have been documented: regulation of neuronal progenitor proliferation-differentiation and the patterning of the cerebellar primordium. Clinical studies have also revealed that ZIC1 gain of function mutations contribute to coronal craniosynostosis, a rare skull malformation.

  4. By unbiased genome-wide DNA methylation profiling and comprehensive stepwise verification and validation studies using in vitro and patient-derived samples, we identified 3 promising methylation markers (GHSR, SST, and ZIC1) associated with a 3q gain for the detection of cervical (pre)cancer

  5. down-regulated expression of ZIC1 contributed to the inhibition of cell proliferation, and inhibited the growth of tumor

  6. our results suggest that the Zic1 promoter methylation rate in plasma-derived DNA is of great significance for the early screening of gastric cancer and monitoring of tumorigenesis

  7. Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability.

  8. ZIC1 might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC.

  9. aberrant methylation is an important mechanism for ZIC1 inactivation in Hepatocellular carcinoma (HCC).

  10. ZIC1 is frequently inactivated by promoter hypermethyaltion and functions as a tumor suppressor in thyroid cancer through modulating PI3K/Akt and MAPK signaling pathways and transcription factor FOXO3a.

  11. Loss of ZIC1 expression is associated with malignant pleural mesothelioma.

  12. Methylation of ZIC1, a putative tumor suppressor, may be a novel determinant of ovarian cancer outcome

  13. Zic transcription factors function in patterning hindbrain motor neurons through their regulation of embryonic retinoic acid signaling

  14. Overexpression of ZIC1 results in inactivation of Shh, PI(3)K and MAPK signaling pathways, as well as regulation of multiple downstream targets which are essential for the development and progression of gastric cancer.

  15. ZIC1 may potentially function as a tumor suppressor gene

  16. The down-regulated expression of ZIC1 and KLOTHO in colorectal carcinoma may relate to promoter methylation.

  17. Dandy-Walker malformation associated with heterozygous ZIC1 and ZIC4 deletion.

  18. ZIC1, ZIC2, and ZIC5 may have roles in meningiomas

  19. ZIC1 contributes to the pathogenesis of liposarcoma. ZIC1 knockdown inhibits proliferation, reduces invasion, and induces apoptosis in dedifferentiated and myxoid/round cell liposarcoma cell lines.

  20. zic-1-mediated transcription is repressed by the intracellular domain of teneurin-2

Xenopus laevis Zinc Finger Protein ZIC 1 (ZIC1) interaction partners

  1. snai2 and sox10 expression was severely impaired upon manipulation of Znf703 expression levels in the embryo suggesting that Znf703 participates in neural crest formation downstream of Pax3 and Zic1 in Xenopus

  2. Zic1, expressed at the anterior neural plate, is necessary and sufficient to promote placode fate.

  3. Pax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers.

  4. Pax3 and Zic1 drive induction and differentiation of multipotent, migratory, and functional neural crest in Xenopus embryos.

  5. XMeis3 protein knock down also causes a loss of primary neuron and neural crest cell lineages, without altering expression of Zic, Sox or Pax3 genes.

  6. Co-activation of Pax3 and Zic1, in concert with Wnt, plays a decisive role for early neural crest determination in the correct place of the Xenopus ectoderm.

  7. These data suggest that interruption of BMP signaling facilitates neural determination via a complex mechanism, involving multiple regulatory factors that cooperate to control zic1 expression

  8. Zic1 directly upregulated the Xfeb gene during early neural development.

  9. Zic1 is an activator of Wnt signaling.

  10. Data show that Pax3 and Zic1 are necessary and sufficient to promote hatching gland and preplacodal fates, respectively, and that their combined activity is essential to specify the neural crest.

  11. aqp-3b was upregulated by Zic1

Mouse (Murine) Zinc Finger Protein ZIC 1 (ZIC1) interaction partners

  1. Geminin and Zic1 could cooperatively activate the expression of several shared targets encoding transcription factors that control neurogenesis, neural plate patterning, and neuronal differentiation.

  2. Zic1 and Zic2 proteins are essential to control the balance between two defined neuron types in the postnatal forebrain.

  3. Brn2-Zic1 axis is essential to specify neural fate in retinoic-acid-treated embryonic stem cells.

  4. Zic1 and Zic2 are required for coordinating mature neuronal gene expression patterns.

  5. Association with DNA-bound Pax3 strengthens the ability of both Zic1 and Gli2 to transactivate Myf5 in the epaxial somite.

  6. Zic1 and Zic4 have both Shh-dependent and -independent roles during cerebellar development and multiple developmental disruptions underlie Zic1/4-related Dandy-walker malformation.

  7. Myf5 activation in newly forming somites is delayed in Zic2 mutant embryos until the time of Zic1 activation, and both Zic2 and Myf5 require noggin for their activation

  8. Zic1, a neural developmental transcription factor, plays an important role in shear flow mechanotransduction in osteocytes.

  9. findings suggest that Zic1 controls the expansion of neuronal precursors by inhibiting the progression of neuronal differentiation

  10. The functions of Zic1 and Zic3 may be essential to increasing neural cell numbers regionally in the medial telencephalon and to proper mediolateral patterning of the telencephalon.

  11. This study reveal a new role for Zic1 as a cell-autonomous regulator of key aspects of nucleus formation and axon pathway choice in the ventral brain stem.

ZIC1 抗原简介


This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.

Gene names and symbols associated with ZIC1

  • Zic family member 1 (ZIC1) 抗体
  • Zic family member 1 (Zic1) 抗体
  • Zic family member 1 S homeolog (zic1.S) 抗体
  • zinc finger protein of the cerebellum 1 (Zic1) 抗体
  • opl 抗体
  • ZIC 抗体
  • ZNF201 抗体

Protein level used designations for ZIC1

Zic family member 1 (odd-paired homolog, Drosophila) , Zinc finger protein of the cerebellum 1 , zinc finger protein 201 , zinc finger protein ZIC 1 , zic protein member 1 , zinc finger protein of the cerebellum 1 , XZic1 , ZIC-r1 , ZIC-related protein 1 , Zic family member 1 (odd-paired homolog) , Zic-related-1 , xlZic1 , xopl , odd-paired homolog

7545 Homo sapiens
64618 Rattus norvegicus
374103 Gallus gallus
399124 Xenopus laevis
22771 Mus musculus
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