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ZIC1 encodes a member of the ZIC family of C2H2-type zinc finger proteins. 再加上，我们可以发ZIC1 蛋白 (5)和数多这个蛋白质的别的产品。
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Human Polyclonal ZIC1 Primary Antibody for ICC, IHC (fro) - ABIN153383
Lipchina, Elkabetz, Hafner, Sheridan, Mihailovic, Tuschl, Sander, Studer, Betel: Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response. in Genes & development 2011
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Human Polyclonal ZIC1 Primary Antibody for ICC, IF - ABIN4366890
Simões-Costa, McKeown, Tan-Cabugao, Sauka-Spengler, Bronner: Dynamic and differential regulation of stem cell factor FoxD3 in the neural crest is Encrypted in the genome. in PLoS genetics 2013
Two proposed mechanisms for Zic-mediated cerebellar developmental control have been documented: regulation of neuronal progenitor proliferation-differentiation and the patterning of the cerebellar primordium. Clinical studies have also revealed that ZIC1 gain of function mutations contribute to coronal craniosynostosis, a rare skull malformation.
By unbiased genome-wide DNA methylation (显示 HELLS 抗体) profiling and comprehensive stepwise verification and validation studies using in vitro and patient-derived samples, we identified 3 promising methylation markers (GHSR (显示 GHSR 抗体), SST (显示 SST 抗体), and ZIC1) associated with a 3q gain for the detection of cervical (pre)cancer
down-regulated expression of ZIC1 contributed to the inhibition of cell proliferation, and inhibited the growth of tumor
our results suggest that the Zic1 promoter methylation rate in plasma-derived DNA is of great significance for the early screening of gastric cancer and monitoring of tumorigenesis
Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability.
ZIC1 might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC.
aberrant methylation is an important mechanism for ZIC1 inactivation in Hepatocellular carcinoma (HCC (显示 FAM126A 抗体)).
ZIC1 is frequently inactivated by promoter hypermethyaltion and functions as a tumor suppressor in thyroid cancer through modulating PI3K (显示 PIK3CA 抗体)/Akt (显示 AKT1 抗体) and MAPK (显示 MAPK1 抗体) signaling pathways and transcription factor FOXO3a (显示 FOXO3 抗体).
Loss of ZIC1 expression is associated with malignant pleural mesothelioma.
Methylation of ZIC1, a putative tumor suppressor, may be a novel determinant of ovarian cancer outcome
snai2 and sox10 (显示 SOX10 抗体) expression was severely impaired upon manipulation of Znf703 (显示 ZNF703 抗体) expression levels in the embryo suggesting that Znf703 (显示 ZNF703 抗体) participates in neural crest formation downstream of Pax3 (显示 PAX3 抗体) and Zic1 (显示 ZIC5 抗体) in Xenopus
Zic1 (显示 ZIC5 抗体), expressed at the anterior neural plate, is necessary and sufficient to promote placode fate.
Pax3 (显示 PAX3 抗体) and Zic1 (显示 ZIC5 抗体) trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers.
Pax3 (显示 PAX3 抗体) and Zic1 (显示 ZIC5 抗体) drive induction and differentiation of multipotent, migratory, and functional neural crest in Xenopus embryos.
XMeis3 (显示 MEIS3 抗体) protein knock down also causes a loss of primary neuron and neural crest cell lineages, without altering expression of Zic, Sox (显示 PIPOX 抗体) or Pax3 (显示 PAX3 抗体) genes.
Co-activation of Pax3 (显示 PAX3 抗体) and Zic1 (显示 ZIC5 抗体), in concert with Wnt (显示 WNT2 抗体), plays a decisive role for early neural crest determination in the correct place of the Xenopus ectoderm.
These data suggest that interruption of BMP signaling facilitates neural determination via a complex mechanism, involving multiple regulatory factors that cooperate to control zic1 (显示 ZIC5 抗体) expression
Zic1 (显示 ZIC5 抗体) directly upregulated the Xfeb gene during early neural development.
Zic1 (显示 ZIC5 抗体) is an activator of Wnt (显示 WNT2 抗体) signaling.
Data show that Pax3 (显示 PAX3 抗体) and Zic1 (显示 ZIC5 抗体) are necessary and sufficient to promote hatching gland and preplacodal fates, respectively, and that their combined activity is essential to specify the neural crest.
Geminin (显示 GMNN 抗体) and Zic1 could cooperatively activate the expression of several shared targets encoding transcription factors that control neurogenesis, neural plate patterning, and neuronal differentiation.
Zic1 and Zic2 (显示 ZIC2 抗体) proteins are essential to control the balance between two defined neuron types in the postnatal forebrain.
Brn2 (显示 POU3F2 抗体)-Zic1 axis is essential to specify neural fate in retinoic-acid-treated embryonic stem cells.
Zic1 and Zic2 (显示 ZIC2 抗体) are required for coordinating mature neuronal gene expression patterns.
Association with DNA-bound Pax3 (显示 PAX3 抗体) strengthens the ability of both Zic1 and Gli2 (显示 GLI2 抗体) to transactivate Myf5 (显示 MYF5 抗体) in the epaxial somite.
Zic1 and Zic4 (显示 ZIC4 抗体) have both Shh (显示 SHH 抗体)-dependent and -independent roles during cerebellar development and multiple developmental disruptions underlie Zic1/4-related Dandy-walker malformation.
Myf5 (显示 MYF5 抗体) activation in newly forming somites is delayed in Zic2 (显示 ZIC2 抗体) mutant embryos until the time of Zic1 activation, and both Zic2 (显示 ZIC2 抗体) and Myf5 (显示 MYF5 抗体) require noggin (显示 NOG 抗体) for their activation
Zic1, a neural developmental transcription factor, plays an important role in shear flow mechanotransduction in osteocytes.
findings suggest that Zic1 controls the expansion of neuronal precursors by inhibiting the progression of neuronal differentiation
The functions of Zic1 and Zic3 (显示 ZIC3 抗体) may be essential to increasing neural cell numbers regionally in the medial telencephalon and to proper mediolateral patterning of the telencephalon.
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.
Zic family member 1 (odd-paired homolog, Drosophila)
, Zinc finger protein of the cerebellum 1
, zinc finger protein 201
, zinc finger protein ZIC 1
, zic protein member 1
, zinc finger protein of the cerebellum 1
, ZIC-related protein 1
, Zic family member 1 (odd-paired homolog)
, odd-paired homolog