ZMYM3 is located on the X chromosome and is subject to X inactivation. 再加上，我们可以发和数多这个蛋白质的别的产品。
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Human Polyclonal ZMYM3 Primary Antibody for ICC, IF - ABIN4366964
Aubry, Shin, Crary, Lefort, Qureshi, Lefebvre, Califano, Shelanski: Assembly and interrogation of Alzheimer's disease genetic networks reveal novel regulators of progression. in PLoS ONE 2015
AGS mutations in this cluster impair the interaction of RNase H2 with several members of the CoREST chromatin-silencing complex that include the histone deacetylase HDAC2 and the demethylase KDM1A, the transcriptional regulators RCOR1 and GTFII-I as well as ZMYM3, an MYM-type zinc finger protein.
The ZMYM3 "exceptionally long" 5' UTR STR findings may alter our perspective of disease pathogenesis in psychiatric disorders, and set an example in which the low frequency alleles at the extreme short and long ends of the human STRs are, at least in part, a result of natural selection against these alleles and their unambiguous link to major human disorders.
Data found skewing of the genetic architecture at the ZMYM3 short tandem repeats (STR) in schizophrenia. Further, results found a bell-shaped distribution of alleles and selection against alleles at the extreme ends of this STR.
Zmym3 KO also resulted in up-regulated expression of meiotic genes in spermatogonia. These results show that ZMYM3 has an essential role in metaphase to anaphase transition during mouse spermatogenesis by regulating the expression of diverse families of genes.
This gene is located on the X chromosome and is subject to X inactivation. It is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X\;13) involving this gene is associated with X-linked mental retardation. Several alternatively spliced transcript variants have been found for this gene.
zinc finger, MYM-type 3
, zinc finger protein 261
, uncharacterized protein LOC553317
, zinc finger MYM-type protein 3
, DXHXS6673E protein