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Vangl1 encodes a member of the tretraspanin family.
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The identification of zebrafish vangl1; the first spatiotemporal expression and functional analysis of a vertebrate vangl1 homologue are described.
In Pax2-Cre; V1V2 Conditional knockout mice, the loss of both VANGL proteins significantly disrupts planar polarity throughout the utricular maculae
Exogenously introduced expression of green fluorescent protein (GFP)-tagged core PCP (显示 BMP1 ELISA试剂盒) factors by electroporation revealed that Vangl1, Vangl2 (显示 VANGL2 ELISA试剂盒) and Prickle2 are localized on the ovarian side of the cell periphery in the oviduct.Our data collectively suggest that the mechanism for maintenance of Vangl2 (显示 VANGL2 ELISA试剂盒) asymmetry in mature mouse oviduct is different from the microtubule dependent polarized transport model
Elevated coexpression of KITENIN and ErbB4 (显示 ERBB4 ELISA试剂盒)-CYT (显示 CYGB ELISA试剂盒)-2 promotes the transition of colon adenoma to adenocarcinoma within an APC (显示 APC ELISA试剂盒) loss-associated tumor microenvironment
Findings identify that KITENIN-targeting miR (显示 MLXIP ELISA试剂盒)-124, miR (显示 MLXIP ELISA试剂盒)-27a, and miR (显示 MLXIP ELISA试剂盒)-30b function as endogenous inhibitors of colorectal cancer cell motility and demonstrate that miR (显示 MLXIP ELISA试剂盒)-124 plays a suppressor role in colorectal tumorigenesis.
Vangl1 and Vangl2 (显示 VANGL2 ELISA试剂盒) may play a key role in the embryo implantation of mice
Celsr2 (显示 CELSR2 ELISA试剂盒)-3 and Fzd3 (显示 FZD3 ELISA试剂盒) regulate axonal navigation in the forebrain by using mechanisms different from classical epithelial core planar cell polarity, and require interacting partners other than Vangl1-2 that remain to be identified.
Vangl1 transcript downregulation might be implicated in the occurrence of mouse NTDs induced by retinoic acid.
Genetic interaction between Vangl1 and Vangl2 (显示 VANGL2 ELISA试剂盒) genes causes neural tube defects. Vangl1(gt/+);Vangl2(lp (显示 VANGL2 ELISA试剂盒)/+) double heterozygotes show profound developmental defects
two rare missense mutations in VANGL1, encoding a receptor involved in WNT (显示 WNT2 ELISA试剂盒)/PCP (显示 PRCP ELISA试剂盒) signaling, may be associated with Adolescent Idiopathic Scoliosis
Study provides evidence that KITENIN functions in the maintenance of a higher expression level of ErbB4 in advanced colorectal cancer tissues, independent of ubiquitin-mediated degradation via Nrdp1.
We first propose the use of a DNA biosensor to detect the missense single nucleotide polymorphism (rs4839469 c.346G>A p.Ala116Thr) of the vangl1 gene
a novel and ultrasensitive sandwich-type immunosensor was fabricated to detect Vangl in human serum using C60-templated AuPt as labels and rGO-TEPA-PTC (显示 F9 ELISA试剂盒)-NH2 as the platform.
Results found that KITENIN is associated with tumor progression by enhancing angiogenesis in colorectal cancer.
Authors silenced VANGL1 gene expression in the HepG2 HCC cell line by stable transfection with a vector containing siRNA template for VANGL1 and investigated the change in cell invasion and motility.
High levels of KITENIN increased glioma invasiveness and progression, and are associated with the up-regulation of EMT (显示 ITK ELISA试剂盒) and stemness markers.
The rs4839469 allele of VANGL1 was obviously associated with neural tube defects (NTDs). And genotype GC increased the risk of NTDs, changes in the three-dimensional protein structure may have impacted its biological functions.
VANGL1 mutations are associated with neural tube defects.
Elevated KITENIN expression is associated with drug resistance in colorectal cancer.
This gene encodes a member of the tretraspanin family. The encoded protein may be involved in mediating intestinal trefoil factor induced wound healing in the intestinal mucosa. Mutations in this gene are associated with neural tube defects. Alternate splicing results in multiple transcript variants.
vang, van gogh-like 1
, vang-like 1 (van gogh, Drosophila)
, vang-like protein 1
, van gogh-like 1
, vang-like protein 1-like
, loop-tail protein 2
, van Gogh-like protein 1
, KAI1 C-terminal interacting tetraspanin
, loop-tail protein 2 homolog
, strabismus 2