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VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. 再加上，我们可以发Vaccinia Related Kinase 1 抗体 (80) 和 Vaccinia Related Kinase 1 蛋白 (16)和数多这个蛋白质的别的产品。
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vrk-1 has a role in early uterine development in Caenorhabditis elegans
By coordinating VRK-1- and PP2A-mediated signaling on BAF, Lem4 and LEM-4L (Y55F3BR.8) controls postmitotic nuclear envelope formation in a function conserved from worms to humans.
Genome-wide analysis of germ cell proliferation in C. elegans identifies vrk-1 as a key regulator of cep-1/p53 (显示 TP53 ELISA试剂盒).
Data show that expression of the fibroblast growth factor-like protein EGL-17 and its receptor EGL-15 is reduced in vrk-1 mutants, suggesting that VRK-1 might act at least partially through activation of FGF signaling.
that knockdown of VRK1 would inhibit the proliferation of glioma cells
this study not only provides a resource for investigating the unidentified functions of VRK1/VRK3, but also an insight into the regulatory roles of VRK1/VRK3 in biological processes.
Block the activation of the VRK1 promoter by Sox2 (显示 SOX2 ELISA试剂盒).
VRK1 and BANF1 yielded AUCs of 0.790 and 0.735, respectively.
VRK1 AND VRK2 (显示 VRK2 ELISA试剂盒) expression are predictive of tumor response to neoadjuvant chemoradiation therapy in rectal adenocarcinoma.
VRK1 was lowly expressed in adherent MM cells and highly expressed in suspended cells. In addition, VRK1 was positively correlated with the proliferation of MM cells by regulating the expression of cell cycle-related protein, such as cyclinD1, CDK2 (显示 CDK2 ELISA试剂盒) and p27(kip1 (显示 CDKN1B ELISA试剂盒)).
we conclude that VRK1 may be a candidate prognostic biomarker as well as a potential therapeutical target of hepatocellular carcinoma
VRK1 may act as a tumor promoter by controlling the level of cell cycle regulators associated with G1/S transition and could potentially serve as a therapeutic target and/or prognostic biomarker for HCC.
VRK1 is a novel regulator of CBs dynamics and stability in cell cycle by protecting coilin from ubiquitination and degradation in the proteasome, and propose a model of CB dynamics.
VRK1 regulation of NBS1 (显示 NBN ELISA试剂盒) contributes to the stability of the repair complex and permits the sequential steps in DNA damage response.
VRK1 self-represses its activity to phosphorylate PXR (显示 NR1I2 ELISA试剂盒) through cyclin-dependent kinase 2 (CDK2 (显示 CDK2 ELISA试剂盒)) in high glucose conditions, resulting in the repression of the PCK1 (显示 PCK1 ELISA试剂盒) gene. This PXR (显示 NR1I2 ELISA试剂盒) phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2 (显示 CDK2 ELISA试剂盒)-PXR (显示 NR1I2 ELISA试剂盒)-PP2Calpha (显示 PPM1A ELISA试剂盒)-SGK2 (显示 SGK2 ELISA试剂盒) pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose.
VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP (显示 APP ELISA试剂盒)). APP (显示 APP ELISA试剂盒) overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP (显示 APP ELISA试剂盒)-dependent mechanism.
Data suggest that VRK1 is required for both follicle development and oocyte growth in mammalian female reproduction system.
Protein kinase (显示 CDK7 ELISA试剂盒) Cdelta regulates phosphorylation and down-regulation of Vaccinia-related kinase 1 (VRK1), thereby contributing to cell cycle arrest and apoptotic cell death in a p53 (显示 TP53 ELISA试剂盒)-dependent manner.
reduction of VRK1 activity causes a delay in meiotic progression during oogenesis
VRK1 is required for the proliferation and differentiation of undifferentiated spermatogonia, which are essential for spermatogenic cell maintenance
Depletion of VRK1 leads to progressive male infertility as a result of a cessation of spermatogonial proliferation.
These findings collectively support a role of VRK1 as a novel mitotic histone H3 (显示 HIST3H3 ELISA试剂盒) kinase in mammals.
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
vaccinia related kinase 1
, serine/threonine-protein kinase VRK1
, serine/threonine-protein kinase VRK1-like
, vaccinia virus B1R-related kinase 1
, vaccinia-related kinase 1
, serine/threonine-protein kinase 51PK