The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009].
custom-made
UBE2L3
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
Koo, Chae, Kim, Kang, Kim, Kwak, Jung, Cho, Choi, Park, Shin, Jang, Shin, Hwang, Yi, Park: "Identification of novel autoantibodies in type 1 diabetic patients using a high-density protein microarray." in: Diabetes, Vol. 63, Issue 9, pp. 3022-32, (2014) (PubMed).