Tyrosine Kinase, Non-Receptor, 1 (TNK1) ELISA试剂盒

The protein encoded by TNK1 belongs to the tyrosine protein kinase family. 再加上,我们可以发TNK1 抗体 (139)TNK1 蛋白 (3)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
TNK1 83813 Q99ML2
TNK1 8711 Q13470
大鼠 TNK1 TNK1 303247  
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适于 TNK1 相互作用对的更多 ELISA 试剂盒

Mouse (Murine) Tyrosine Kinase, Non-Receptor, 1 (TNK1) interaction partners

  1. The activated TNK1 potentiates JAK-STAT signaling through dual phosphorylation of STAT1 at tyrosine 701 and serine 727 amino acid positions.

  2. data support a negative regulatory role for Kos1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity

  3. Tnk1/Kos1 is a tumor suppressor that functions to down-regulate Ras activity

  4. cellular stress reverses the repression of Tnk1/Kos1 and induces its expression through increased high affinity interactions between nuclear proteins Sp1, Sp3, AP2 and MED1 for the m-Tnk1 promoter

Human Tyrosine Kinase, Non-Receptor, 1 (TNK1) interaction partners

  1. the Single nucleotide polymorphisms rs11136000 of CLU, rs541458 of PICALM, and rs1554948 of TNK1 according to the three age groups 50-65 years (group 1), 66-80 years (group 2), and 80+ years (group 3) in 569 older subjects without cognitive impairment (NoCI) and 520 Alzheimer's disease (AD) patients, were studied.

  2. The activated TNK1 potentiates JAK-STAT signaling through dual phosphorylation of STAT1 at tyrosine 701 and serine 727 amino acid positions.

  3. The application of functional genomics by using high-throughput-RNAi screens has allowed us to identify TNK1 as a growth-associated kinase in pancreatic cancer cells.

  4. Activated Tnk1 kinase is associated with Hodgkin's lymphoma.

  5. TNK1 therefore acts as a novel molecular switch that can determine the properties of TNFalpha signaling and therefore cell death.

TNK1 抗原简介

Antigen Summary

The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TNK1

  • tyrosine kinase non receptor 1 (TNK1) 抗体
  • tyrosine kinase, non-receptor, 1 (Tnk1) 抗体
  • tyrosine kinase non receptor 1 (Tnk1) 抗体
  • Ack-like 抗体
  • Kos1 抗体
  • Tnk1a 抗体
  • Tnk1b 抗体

Protein level used designations for TNK1

kinase of embryonic stem cells , non-receptor tyrosine kinase , non-receptor tyrosine-protein kinase TNK1 , CD38 negative kinase 1

GENE ID SPECIES
100061776 Equus caballus
83813 Mus musculus
8711 Homo sapiens
303247 Rattus norvegicus
510356 Bos taurus
489470 Canis lupus familiaris
100735628 Cavia porcellus
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