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TP63 encodes a member of the p53 family of transcription factors. 再加上，我们可以发p63 抗体 (77) 和 p63 蛋白 (7)和数多这个蛋白质的别的产品。
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the strong repression of Np63 by H-RAS (显示 HRAS ELISA试剂盒) and PIK3CA (显示 PIK3CA ELISA试剂盒) and induction of EMT (显示 ITK ELISA试剂盒) suggest that this process is critical for mammary tumorigenesis.
This study suggests that in patients with CD30 (显示 TNFRSF8 ELISA试剂盒)+ lymphoproliferative disorders, an aggressive clinical course cannot be defined by the presence of TP63 rearrangements, as was recently shown in systemic ALK (显示 ALK ELISA试剂盒) negative anaplastic large cell lymphoma.
This study revealed the possible association between TP63 and Mullerian duct anomalies and suggested a potential contribution of microRNA-regulated expression of genes in the etiology of Mullerian duct anomalies.
We identified a list of thirty genes repressed by DeltaNp63 in a SETDB1 (显示 SETDB1 ELISA试剂盒)-dependent manner, whose expression is positively correlated to survival of breast cancer patients. These results suggest that p63 (显示 RPE65 ELISA试剂盒) and SETDB1 (显示 SETDB1 ELISA试剂盒) expression, together with the repressed genes, may have diagnostic and prognostic potential
Dysregulation of JAM-A (显示 F11R ELISA试剂盒) via p63 (显示 RPE65 ELISA试剂盒)/GATA-3 (显示 GATA3 ELISA试剂盒) signaling pathway occurs in squamous cell carcinomas of the head and neck.
This study investigated the expression of p40 (显示 IL9 ELISA试剂盒) protein in meningiomas and explored its usefulness as prognostic marker in addition to PgR (显示 PGR ELISA试剂盒) and Ki67 (显示 MKI67 ELISA试剂盒).
the transactivation inhibitory (TI) domains within the alpha-isoform-specific C termini of p63 (显示 RPE65 ELISA试剂盒) and p73 (显示 TP73 ELISA试剂盒) are essential for binding to p53R175H.
Data show that a two-marker panel of p40 (显示 IL9 ELISA试剂盒) (DeltaNp63) and CDX2 (显示 CDX2 ELISA试剂盒) is highly sensitive and specific.
DeltaNp63alpha (TP63) is co-expressed with FAT2 and Slug in patient tumors and the elevated expression of DeltaNp63alpha, FAT2 and Slug correlated with poor patient outcome.
Keratin14/p63 (显示 RPE65 ELISA试剂盒)-positive epithelial proliferations suggest benign breast disease.
p63 expression was significantly lower in the chronic laminitic hoof than in that of control horses
they unravel essential roles of TAp63 and p53 (显示 TP53 ELISA试剂盒) to promote both keratinocyte proliferation and their terminal differentiation by promoting Notch (显示 NOTCH1 ELISA试剂盒) signalling and caspase 3 (显示 CASP3 ELISA试剂盒) activity.
the p63 transcription factor is upregulated to initiate this apoptotic pathway and directly activates puma (显示 BBC3 ELISA试剂盒) transcription in response to ER stress.
Early zebrafish embryos express a dominant-negative form of p63 (DeltaNp63), which accumulates in the nucleus just as epidermal growth begins. (p63)
DeltaNp63 expression blocks neural development and promotes nonneural development, even in the absence of Bmp signaling. (DeltaNp63)
rps19 (显示 RPS19 ELISA试剂盒)-deficient phenotype is mediated by dysregulation of deltaNp63 and p53 (显示 TP53 ELISA试剂盒) and results in hematopoietic and developmental abnormalities resembling Diamond-Blackfan anemia
Overexpression of DeltaNp63 in transgenic mouse epidermis results in a severe skin phenotype that shares many of the key clinical, histological and molecular features associated with Atopic dermatitis and IL-31 (显示 IL31 ELISA试剂盒) and IL-33 (显示 IL33 ELISA试剂盒) are key players in the signaling pathways.
cells expressing both p63 (显示 CKAP4 ELISA试剂盒) and p73 (显示 ARHGAP24 ELISA试剂盒) exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes.
Data suggest that this the selective targeting of genes by tumor suppressor protein (显示 TP53 ELISA试剂盒) p63 (p63 (显示 CKAP4 ELISA试剂盒)) correlates with subtle, but measurable transcriptional differences in mouse and human keratinocytes that converges on major metabolic processes, which often exhibit species-specific trends.
p63alpha protein up-regulates heat shock protein 70 (显示 HSP70 ELISA试剂盒) expression via E2F1 transcription factor (显示 E2F1 ELISA试剂盒) 1 (显示 HNF1A ELISA试剂盒), promoting Wasf3/Wave3 (显示 WASF3 ELISA试剂盒)/MMP9 (显示 MMP9 ELISA试剂盒) signaling and bladder cancer invasion
these results therefore highlight an unanticipated role for p53 (显示 TP53 ELISA试剂盒) family proteins in a regulatory network that integrates essential Wnt (显示 WNT2 ELISA试剂盒)-Tcf (显示 HNF4A ELISA试剂盒) and nodal-Smad (显示 SMAD1 ELISA试剂盒) inputs.
the double mutant spermatocytes apoptosed at late pachynema because of sex body deficiency; thus p53 (显示 TP53 ELISA试剂盒) and TAp63 are dispensable for arrest caused by sex body defects. These data affirm that recombination-dependent and sex body-deficient arrests occur via genetically separable mechanisms.
TGFb3 (显示 TGFB3 ELISA试剂盒)-induced down-regulation of p63 (显示 CKAP4 ELISA试剂盒) in the medial edge epithelia of the palatal shelves is a pre-requisite for palatal fusion by facilitating periderm migration from, and reducing the proliferative potential of, the midline epithelial seam thereby preventing cleft palate.
miR-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression.
Taken together, these data show that p63 (显示 CKAP4 ELISA试剂盒) regulates the self-renewal and differentiation of oesophageal stem cells in humans and mice.
IL-6 (显示 IL6 ELISA试剂盒)/P-STAT3 (显示 STAT3 ELISA试剂盒) activation influences p63 (显示 CKAP4 ELISA试剂盒) isoform expression in healing wounds, which may contribute to wound-induced hair follicle neogenesis.
Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.
The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4 (显示 BMP4 ELISA试剂盒).
The role of p63 as a negative Wnt (显示 WNT2 ELISA试剂盒)-regulator thus matches with the frequently observed downregulation of p63 during tumor progression, when cancer cells adopt a more mesenchymal, invasive phenotype.
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
, amplified in squamous cell carcinoma
, chronic ulcerative stomatitis protein
, keratinocyte transcription factor KET
, transformation-related protein 63
, tumor protein 63
, tumor protein p53-competing protein
, tumor protein p63 deltaN isoform delta
, tumor protein p63
, transformation related protein 63
, tumor protein 63 kDa
, tumor protein 63-like