Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Wang, Sips, Khin, Rotival, Sun, Ahmed, Widjaja, Schafer, Yusoff, Choksi, Ko, Singh, Epstein, Guan, Houštěk, Mracek, Nuskova, Mikell, Tan, Pesce, Kolar, Bottolo, Mancini, Hubner, Pravenec, Petretto et al.: "Wars2 is a determinant of angiogenesis. ..." in: Nature communications, Vol. 7, pp. 12061, (2016) (PubMed).
Miyanokoshi, Tanaka, Tamai, Tagawa, Wakasugi: "Expression of the rodent-specific alternative splice variant of tryptophanyl-tRNA synthetase in murine tissues and cells." in: Scientific reports, Vol. 3, pp. 3477, (2013) (PubMed).
Guo, Chen, Zhao, Shi, Li, Xue, Jin: "Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311." in: Nucleic acids research, Vol. 35, Issue 17, pp. 5934-43, (2007) (PubMed).
Liu, Shue, Ewalt, Schimmel: "A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase." in: Nucleic acids research, Vol. 32, Issue 2, pp. 719-27, (2004) (PubMed).
Jorgensen, Søgaard, Rossing, Martensen, Justesen: "Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase." in: The Journal of biological chemistry, Vol. 275, Issue 22, pp. 16820-6, (2000) (PubMed).