(Transient Receptor Potential Cation Channel, Subfamily V, Member 5 (TRPV5))
This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008].
Kennedy, Torabi, Kurzawa, Echtenkamp, Mangini: "Expression of transient receptor potential vanilloid channels TRPV5 and TRPV6 in retinal pigment epithelium." in: Molecular vision, Vol. 16, pp. 665-75, (2010) (PubMed).
Cha, Wu, Huang: "Protein kinase C inhibits caveolae-mediated endocytosis of TRPV5." in: American journal of physiology. Renal physiology, Vol. 294, Issue 5, pp. F1212-21, (2008) (PubMed).
van der Eerden, Hoenderop, de Vries, Schoenmaker, Buurman, Uitterlinden, Pols, Bindels, van Leeuwen: "The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 48, pp. 17507-12, (2005) (PubMed).