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TJP2 encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. 再加上，我们可以发TJP2 抗体 (106) 和 TJP2 蛋白 (4)和数多这个蛋白质的别的产品。
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Patients with a confirmed ABCB11 (显示 ABCB11 ELISA试剂盒) or tight junction protein 2 gene mutation (n = 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs). Three patients with an ATP8B1 (显示 ATP8B1 ELISA试剂盒) mutation had an elevated THBA proportion (7.51-37.26%).
Studies indicate the modular and supramodular organization of zonula occludens protein 2 (ZO-2) that allows it to interact with a wide variety of molecules, including cell-cell adhesion proteins, cytoskeletal components, and nuclear factors.
Data identified two Disease-causing Genes TJP2 and GJB2 (显示 GJB2 ELISA试剂盒) in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment.
TJP2 deficiency may predispose to hepatocellular carcinoma in early childhood
Claudin-19 (显示 CLDN19 ELISA试剂盒), the most abundant claudin in myelin, exhibited no binding to ZO2.
JAM-A (显示 F11R ELISA试剂盒) regulates epithelial permeability via association with ZO-2, afadin (显示 MLLT4 ELISA试剂盒), and PDZ-GEF1 (显示 RAPGEF2 ELISA试剂盒) to activate Rap2c (显示 RAP2C ELISA试剂盒) and control contraction of the apical cytoskeleton.
Protein-truncating mutations in the tight junction protein 2 gene cause failure of protein localization and disruption of tight-junction structure, leading to severe cholestatic liver disease.
demonstrated that ZO-2 inhibition increases invasive and migrative capacities of invasive tumor cells. This was associated with an increase of MT1-MMP (显示 MMP14 ELISA试剂盒)
the Alu-related transcript of TJP2 gene (TJP2-Alu transcript) was differentially expressed between colorectal tumor and normal tissues; potential diagnostic markers for colorectal cancer.
ZO-2 inhibits the Wnt (显示 WNT2 ELISA试剂盒) signaling pathway, reduces cell proliferation, and promotes apoptosis; its absence, mutation, or overexpression is present in various human diseases, including deafness and cancer.
In the present study, we found that the protein level of ZO-2, a scaffolding tight junction protein (显示 OCLN ELISA试剂盒), decreased in the bladder of OVX mice indicating a possible role in overactive bladder.
Expression of Podocalyxin (显示 PODXL ELISA试剂盒), which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 (显示 TJP1 ELISA试剂盒) and ZO-2 and this correlates with an aberrant submembranous localization of Ezrin (显示 EZR ELISA试剂盒).
SNX27 (显示 SNX27 ELISA试剂盒) associates with ZO-2 and modulates the epithelial tight junction.
ZO-2 protects against podocyte dysfunction induced by adreiamycin. This action is regulated by ZO-2-mediated inhibition of the Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling pathway
the first PDZ domain (显示 INADL ELISA试剂盒) of ZO-2 interacts with YAP2 (显示 YAP1 ELISA试剂盒) to form complex; ZO-2 facilitates both nuclear translocation of YAP2 (显示 YAP1 ELISA试剂盒) & pro-apoptotic function of YAP2 (显示 YAP1 ELISA试剂盒); these activities of ZO-2 are PDZ-domain (显示 INADL ELISA试剂盒)-dependent
Male ZO-2 chimeras show reduced fertility and pathological changes in the testis. Lanthanum tracer experiments show a compromised blood-testis barrier.
nuclear ZO-2 is present in epithelial and endothelial cells, particularly in response to environmental stress conditions
ZO-1 (显示 TJP1 ELISA试剂盒) and ZO-2 function redundantly to some extent in junction formation/epithelial polarization but they are not functionally identical
These findings indicate that ZO-1 (显示 TJP1 ELISA试剂盒) and ZO-2 can independently determine whether and where claudins are polymerized.
These results suggest novel roles for ZO proteins as Src (显示 SRC ELISA试剂盒)/Csk (显示 CSK ELISA试剂盒) scaffolds potentially involved in the regulation of Src (显示 SRC ELISA试剂盒) transformation.
analysis of tissue distribution and developmental expression of tjp1/zo-1 (显示 TJP1 ELISA试剂盒), tjp2/zo-2 and tjp3/zo-3 (显示 TJP3 ELISA试剂盒) in the zebrafish, Danio rerio
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
Friedreich ataxia region gene X104 (tight junction protein ZO-2)
, tight junction protein ZO-2
, zona occludens 2
, zonula occludens protein 2
, tight junction protein 2 (zona occludens 2)
, Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2)
, zona occludens protein 2
, tight junction protein 2 L homeolog
, tight junction protein 2b