Thiopurine S-Methyltransferase (TPMT) ELISA试剂盒

TPMT encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. 再加上,我们可以发TPMT 抗体 (111)TPMT 蛋白 (25)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
TPMT 22017 O55060
TPMT 7172 P51580
TPMT 690050  
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0.113 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests Log in to see 13至16个工作日
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适于 TPMT 相互作用对的更多 ELISA 试剂盒

Mouse (Murine) Thiopurine S-Methyltransferase (TPMT) interaction partners

  1. With the significant mitigation of TPMT wild type-expressing cells to cisplatin cytotoxicity, findings demonstrate a drug-gene interaction between increased TPMT activity and decreased susceptibility to cisplatin-induced toxicity of inner ear cells.

  2. These findings support the notion that germline polymorphisms in Tpmt affect not only host tissue toxicity but also antitumor effectiveness.

  3. suggestion that differential mouse TPMT activity is due to variation in mRNA expression

Human Thiopurine S-Methyltransferase (TPMT) interaction partners

  1. Patients also developed infection who mostly (71%) needed hospitalization. None of the studied G238C, G460A and A719G TPMT variant alleles were detected. Infections and febrile neutropenia were common causes of 6-PM dose modification and interruption.

  2. ANCA associated vasculitis (AAV) patients treated with cyclophosphamide induction and azathioprine maintenance therapy were included and followed for 60 months. TPMT genotype and activity were not independent predictors of relapse, and could not predict leukopenia or other adverse effects from azathioprine.

  3. Results show no association between TPMT or COMT (显示 COMT ELISA试剂盒) single-nucleotide polymorphisms and cisplatin-induced ototoxicity.

  4. Of the 14 patients intolerant to thiopurines, NGS identified deleterious TPMT variants in 5 individuals whereas the biochemical test identified 8 individuals as intolerant (sensitivity 35.7% and 57.14%; specificity 93.75% and 50% respectively). SKAT-O test identified a significant association between MOCOS (显示 MOCOS ELISA试剂盒) gene and TPMT activity (p = 0.0015), not previously reported.

  5. genetic association studies in cohort in Denmark: Data suggest that standard immunosuppression treatment failure in patients with autoimmune hepatitis is not associated with thiopurine S-methyltransferase genetic variants or HLA-DRB1 (显示 HLA-DRB1 ELISA试剂盒)*03 genotype in the population studied. (HLA-DRB1 (显示 HLA-DRB1 ELISA试剂盒) = major histocompatibility complex class II DR beta 1 (显示 HLA-DRB1 ELISA试剂盒))

  6. This article reviews the thiopurine pharmacogenetics and the methods applied in common practice to evaluate patient's TPMT status. [review]

  7. study aimed to determine the relationship between thiopurine metabolite levels and therapeutic response, and to investigate the association of NUDT15, TPMT, and thiopurine metabolites with leukopenia in patients with CD

  8. TPMT*3C is overrepresented in acute lymphoblastic leukemia (ALL) cases in comparison with non-ALL group

  9. The frequency of TPMT mutation in a homogeneous Sicilian cohort of patients with inflammatory bowel disease, autoimmune and hematological disorders was low. TPMT genotyping is not a sensitive tool for predicting thiopurine-induced leukopenia.

  10. meta-analysis of three independent GWAS of TPMT activity; only genetic variants mapping to chromosome 6, including the TPMT gene region, were significantly associated with TPMT activity;finding is consistent with TPMT genotype being the primary determinant of TPMT activity

TPMT 抗原简介

Antigen Summary

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.

Gene names and symbols associated with TPMT

  • thiopurine S-methyltransferase L homeolog (tpmt.L) 抗体
  • thiopurine S-methyltransferase, tandem duplicate 2 (tpmt.2) 抗体
  • thiopurine S-methyltransferase TpmT (tpmT) 抗体
  • thiopurine S-methyltransferase (MCA0794) 抗体
  • thiopurine S-methyltransferase (Pnap_4948) 抗体
  • thiopurine S-methyltransferase (Hhal_1383) 抗体
  • thiopurine S-methyltransferase (TK90_1044) 抗体
  • thiopurine S-methyltransferase (Slit_1144) 抗体
  • thiopurine S-methyltransferase (Tint_0842) 抗体
  • Thiopurine S-methyltransferase (Fbal_3334) 抗体
  • thiopurine S-methyltransferase (Celly_3188) 抗体
  • thiopurine S-methyltransferase (Weevi_1737) 抗体
  • Thiopurine S-methyltransferase (Psefu_2696) 抗体
  • Thiopurine S-methyltransferase (Metme_3860) 抗体
  • thiopurine methyltransferase (Tpmt) 抗体
  • thiopurine S-methyltransferase (TPMT) 抗体
  • thiopurine S-methyltransferase (Tpmt) 抗体
  • AW106912 抗体
  • MGC84277 抗体
  • NHLRC1 抗体

Protein level used designations for TPMT

thiopurine S-methyltransferase , Thiopurine S-methyltransferase , S-adenosyl-L-methionine:thiopurine S-methyltransferase , thiopurine methyltransferase , NHL repeat containing 1

GENE ID SPECIES
447769 Xenopus laevis
573111 Danio rerio
1168449 Shewanella oneidensis MR-1
3104309 Methylococcus capsulatus str. Bath
4685796 Polaromonas naphthalenivorans CJ2
4711327 Halorhodospira halophila SL1
8806802 Thioalkalivibrio sp. K90mix
8891817 Sideroxydans lithotrophicus ES-1
9151573 Thiomonas intermedia K12
9772187 Ferrimonas balearica DSM 9799
10265228 Cellulophaga lytica DSM 7489
10282995 Weeksella virosa DSM 16922
10657285 Pseudomonas fulva 12-X
10673875 Methylomonas methanica MC09
22017 Mus musculus
7172 Homo sapiens
403536 Canis lupus familiaris
511644 Bos taurus
690050 Rattus norvegicus
493759 Felis catus
100034066 Equus caballus
100009411 Oryctolagus cuniculus
471863 Pan troglodytes
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