anti-Sterol O-Acyltransferase 2 (SOAT2) 抗体

SOAT2 is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. 再加上,我们可以发SOAT2 蛋白 (11)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
SOAT2 8435 O75908
SOAT2 223920 O88908
SOAT2 266770 Q7TQM4
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Showing 10 out of 26 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
小鼠 非结合性 IHC, IHC (p) 100 μL Log in to see 11至14个工作日
$522.50
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非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti SOAT2/ACAT2 Polyclonal Antibody, Unconjugated (ABIN708476) at 1:200 followed by conjugation to the secondary antibody and DAB staining L1 rat intestine lysates L2 rat brain lysates probed with Anti SOAT2/ACAT2 Polyclonal Antibody, Unconjugated (ABIN708476) at 1:200 overnight at 4 °C. Followed by conjugation to secondary antibody at 1:3000 for 90 min at 37 °C. Predicted band 57kD. Observed band size:57kD. 100 μL Log in to see 3至7个工作日
$317.90
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小鼠 非结合性 IHC 0.1 mL Log in to see 2至3个工作日
$482.90
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小鼠 非结合性 IHC Immunohistochemistry: SOAT 2 Antibody (2D3) [NBP2-45981] - Analysis of Human lymph node tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Immunohistochemistry: SOAT 2 Antibody (2D3) [NBP2-45981] - Analysis of Adenocarcinoma of Human colon tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) 0.1 mL Log in to see 8至11个工作日
$587.60
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Alexa Fluor 350 IF (p)   100 μL Log in to see 14至21个工作日
$416.90
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Alexa Fluor 555 IF (p)   100 μL Log in to see 14至21个工作日
$416.90
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Alexa Fluor 647 IF (p)   100 μL Log in to see 14至21个工作日
$416.90
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Alexa Fluor 488 IF (p)   100 μL Log in to see 14至21个工作日
$416.90
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Cy5 IF (p)   100 μL Log in to see 14至21个工作日
$416.90
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Cy3 IF (p)   100 μL Log in to see 14至21个工作日
$416.90
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更多抗SOAT2的相互作用对抗体

Human Sterol O-Acyltransferase 2 (SOAT2) interaction partners

  1. Describe a gender-related difference in hepatic ACAT2 activity in normolipidemic non-obese Chinese patients suggesting a possible role for ACAT2 in the regulation of cholesterol metabolism in humans.

  2. ACAT-2 expression was negative in clear cell type renal cell carcinoma and normal kidney.

  3. ACAT2 expression was induced upon R1881 (androgen agonist) treatment in prostate cancer cells

  4. HNF4alpha positively regulates ACAT2 gene expression at mRNA level. Overexpression of HNF4alpha increased ACAT2 expression, whereas knockdown of HNF4alpha decreased ACAT2 expression.

  5. results show that the enzymatic activity of mutant Glu(14)Gly is approximately two times higher than wildtype, and that this increase is primarily due to the increased expression and/or stability of the mutant ACAT2 protein

  6. Low ACAT2 expression is associated with clear cell renal cell carcinoma.

  7. data demonstrate that the ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters (CE/SE), and suggest that the excretion of lipoproteins containing the ACAT2-catalyzed CS/SE may avoid cytotoxicity

  8. Lipid-induced stabilization of ACAT2 ameliorates lipotoxicity from excessive cholesterol and fatty acid. Cysteine ubiquitylation of ACAT2 constitutes an important mechanism for sensing lipid-overload-induced ROS and fine-tuning lipid homeostasis.

  9. human ACAT2 is transcriptionally regulated by cholesterol.

  10. TG-interacting factor 1 (Tgif1) is an important repressor of SOAT2 gene expression.

  11. CDX2, a known positive regulator of hepatocyte differentiation, was regulated by miR-181d and directly activated SOAT2 gene expression.

  12. We found a new single-nucleotide polymorphism (SNP; a point mutation in intron 1, IVS1 -8 G-->C) in the ACAT-2 gene. Our data suggest that the ACAT-2 gene may not affect lipid levels in humans.

  13. Fully differentiated macrophages express ACAT2 in addition to ACAT1 under various pathologic conditions.

  14. ACAT-1 transcripts predominate in human liver and ACAT-2 transcripts predominate in human duodenum and support the notion that ACAT-2 has an important regulatory role in liver and intestine.

  15. increasing DGAT1, ACAT1, or ACAT2 expression stimulates the assembly and secretion of VLDL from liver cells

  16. ACAT2 provided the major cholesterol-esterifying activity in 3 of 4 human liver samples.

  17. transcription factors hepatic nuclear factor 1 (HNF1)alpha and beta play an important part in the regulation of the ACAT2 promoter

  18. The structural features of various sterols as substrates and/or activators of ACAT1 and ACAT2 in vitro are reported.

  19. Serum-induced depletion of cellular cholesterol available for esterification by ACAT was a strong, independent predictor of major adverse cardiovascular events and death.

  20. Elevated ACAT2 expression may serve as a new biomarker for certain form(s) of hepatocellular carcinoma.

Mouse (Murine) Sterol O-Acyltransferase 2 (SOAT2) interaction partners

  1. ACAT2 provides core CE of newly secreted VLDL, whereas LCAT adds CE during LDL particle formation

  2. ABCA1, especially in the absence of ACAT2, can have a significant effect on cholesterol absorption, although ACAT2 has a more substantial role in this process than ABCA1

  3. depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss

  4. Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization.

  5. Pyripyropene ACAT2-selective inhibition in the intestine and the liver can be effective against atherosclerosis.

  6. inhibition of intestinal or hepatic ACAT2 improves atherogenic hyperlipidemia and limits hepatic cholesteryl ester accumulation

  7. handling of sterols by the intestine involves both G5G8 and ACAT2 but that an additional factor (possibly Niemann-Pick C1-like 1) may be key in determining absorption efficiency

  8. ACAT2 seems to be a hepatic player affecting the cholesterol fluxes fated to VLDL or to HDL, the latter via up-regulation of ABCA1

  9. Intestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol absorption with chylomicrons and HDLs

  10. lipid-induced stabilization of ACAT2 ameliorates lipotoxicity from excessive cholesterol and fatty acid. This unconventional cysteine ubiquitylation of ACAT2 constitutes an important mechanism for sensing lipid-overload-induced ROS and fine-tuning lipid homeostasis.

  11. These studies demonstrate that SOAT2 is a negative regulator of LXR-stimulated fecal neutral sterol loss in mice.

  12. Hepatic knockdown of SOAT2 in apoB100-only, LDLr(-/-) mice resulted in remodeling of aortic atherosclerotic lesions into a stable phenotype, suggesting SOAT2 is a viable target for the treatment of atherosclerosis.

  13. SOAT2 causes hepatic cholesterol to be swiftly mobilized and packaged onto nascent lipoproteins that feed cholesterol into the TICE pathway for fecal excretion.

  14. effect the loss of SOAT2 function has on tissue esterified cholesterol sequestration in lysosomal acid lipase-deficient mice in a model of cholesteryl ester storage disease

  15. Aortic atherosclerosis development was significantly lower in SOAT2 knock-out mice.

  16. ACAT2 increases cholesterol absorption efficiency by providing cholesterol esters for chylomicron transport, but 1 copy of the Acat2 gene, providing approximately 50% of ACAT2 mRNA and enzyme activity, was as effective as 2 copies in promoting cholesterol absorption.

  17. ACAT2-derived cholesterol esters have a crucial role in the development of atherosclerosis in mice

  18. ACAT2 displays a greater capacity than ACAT1 to differentiate cholesterol from sitosterol

  19. ACAT2-derived cholesteryl ester is the predominant atherogenic lipid in blood.

  20. ACAT2 deficiency limits cholesterol absorption. Extent it impacts hepatic cholesterol homeostasis depends on cholesterol intake. Loss of ACAT2 activity may result in unesterified cholesterol being absorbed via ABCA1-mediated basolateral efflux pathway.

Zebrafish Sterol O-Acyltransferase 2 (SOAT2) interaction partners

  1. These results indicated that zebrafish Soat2 is catalytically active in synthesizing cholesteryl esters and contributes to the yolk cholesterol trafficking during zebrafish embryogenesis.

SOAT2 抗原简介

蛋白简介

This gene is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very low density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Gene names and symbols associated with SOAT2

  • sterol O-acyltransferase 2 (SOAT2) 抗体
  • sterol O-acyltransferase 2 (Soat2) 抗体
  • sterol O-acyltransferase 2 S homeolog (soat2.S) 抗体
  • sterol O-acyltransferase 2 (LELG_02432) 抗体
  • sterol O-acyltransferase 2 (PTRG_09319) 抗体
  • sterol O-acyltransferase 2 (MGYG_01129) 抗体
  • sterol O-acyltransferase 2 (Tsp_07565) 抗体
  • sterol O-acyltransferase 2 (soat2) 抗体
  • ACACT2 抗体
  • Acat-2 抗体
  • ACAT2 抗体
  • ARGP2 抗体
  • D15Wsu97e 抗体
  • MGC154806 抗体
  • soat2 抗体

Protein level used designations for SOAT2

ACAT-2 , acyl Co-A: cholesterol acyltransferase 2 , acyl coenzyme A:cholesterol acyltransferase 2 , acyl-CoA:cholesterol acyltransferase 2 , acyl-coenzyme A:cholesterol acyltransferase 2 , cholesterol acyltransferase 2 , acyl-CoA:cholesterol acyltransferase , sterol O-acyltransferase 2 , acyl coenzyme A cholesterol acyltransferase 2

GENE ID SPECIES
8435 Homo sapiens
223920 Mus musculus
266770 Rattus norvegicus
486511 Canis lupus familiaris
513554 Bos taurus
737291 Pan troglodytes
779411 Xenopus laevis
5233427 Lodderomyces elongisporus NRRL YB-4239
6347609 Pyrenophora tritici-repentis Pt-1C-BFP
10032368 Arthroderma gypseum CBS 118893
10902124 Trichinella spiralis
100124290 Monodelphis domestica
100146367 Equus caballus
100216296 Xenopus (Silurana) tropicalis
564868 Danio rerio
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