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SPAG11B encodes several androgen-dependent, epididymis-specific secretory proteins. 再加上，我们可以发Sperm Associated Antigen 11B 抗体 (9)和数多这个蛋白质的别的产品。
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we report the three dimensional structure of the human SPAG11B proteins and their C-terminal peptides. web-based hydropathy, amphipathicity, and topology (WHAT) analyses and grand average of hydropathy
Isoform C of SPAG11B encodes a peptide with antimicrobial activity against E. coli.
Combination of two proteins, SPAG11B and TEX101, can be used for differential diagnosis of azoospermia
SPAG11B/D is both a substrate and a potent inhibitor of TPSAB1 activity.
HE2 peptides were detected in human epididymal epithelium, epididymal fluid, and ejaculate
HE2 transcriptional and translational products normally expressed in the caput epididymidis were not affected by vasectomy.
EP2 expression is more widespread in male reproductive tract than realized previously. Activity of every EP2 variant tested is antibacterial. Further investigation may reveal additional roles for EP2 peptides in primate male reproductive tract.
In the chimpanzee epididymis, several mRNA HE2/EP2 variants are produced. Of these, three cDNAs code for two different protein sequences that have a cysteine distribution characteristic for beta-defensins.
The human HE2/EP2 gene is the fusion product of two ancestral beta-defensin genes. During its evolution, the gene has acquired additional exons whose inclusion produces new message variants that encode peptides unrelated to defensins.
Data suggest that Spag11a has a specific role in epididymal sperm maturation.
Model was developed in which Bin1b was exclusively overexpressed by up to 50-fold in the caput epididymis. The transgenic mice are healthy with normal reproductive activity, but are more resistant to epididymal infection from E coli than normal animals.
increased expression in response to lipopolysaccharide administration
The epididymis-specific expression pattern of the beta-defensin isoform EP2e has been characterized.
SPAG11 isoforms perform both immune and reproductive functions in cattle.
This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined.
epididymal protein 2B
, human epididymis-specific protein 2
, sperm antigen HE2
, sperm-associated antigen 11B
, anti-microbial-like protein BIN-1B
, antimicrobial-like protein Bin-1b
, sperm associated antigen 11
, sperm-associated antigen 11
, beta-defensin-like peptide
, sperm-associated antigen 11c/h
, sperm associated antigen 11B
, antimicrobial peptide Bin1b
, beta defensin EP2e