Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) 蛋白 (SPAM1)

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. 再加上,我们可以发SPAM1 抗体 (32)SPAM1 试剂盒 (6)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
小鼠 SPAM1 SPAM1 20690 P48794
SPAM1 6677 P38567
大鼠 SPAM1 SPAM1 117037 Q62803
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
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HEK-293 Cells His tag 50 μg Log in to see 2至3个工作日
$1,025.00
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HEK-293 Cells His tag Human PH20, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%. 200 μg Log in to see 2至3个工作日
$1,375.00
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
$414.29
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酵母菌 Cynomolgus His tag   1 mg Log in to see 60至71个工作日
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酵母菌 豚鼠 His tag   1 mg Log in to see 60至71个工作日
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HEK-293 Cells His tag   0.025 mg Log in to see 2至3个工作日
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SPAM1 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,

更多Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1)互动伙伴

Mouse (Murine) Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) interaction partners

  1. PH20 is elevated in demyelinating lesions and that increased PH20 expression is sufficient to inhibit oligodendrocyte precursor cell maturation and remyelination.

  2. ACR (显示 ACR 蛋白) or PRSS21 (显示 PRSS21 蛋白) or both may function cooperatively with SPAM1 in sperm/cumulus penetration

  3. The data from this paper suggests that the hyaluronan-degrading activity of the sperm hyaluronidase (显示 HAase 蛋白) SPAM1 may not be required for fertilization, at least in the mouse.

  4. Entrapment of spontaneous Spam1 mutations, owing to recombination suppression near the Robertsonion translocation junctions, is proposed as the major underlying defect of the sperm dysfunction.

  5. sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg

  6. Epididymal Spam1 is secreted predominantly as insoluble particles. Majority of epididymal Spam1 is released with its lipid anchor, a form in which it can bind to sperm.

  7. Spam1 is a multifunctional protein and that it is less restricted in its expression than previously reported

  8. Sperm adhesion molecule 1 (SPAM1) is distributed in the nonciliated epithelial cells. Efferent ducts have the most intense staining. Spam1 was also present in the accessory organs, the prostate, and seminal vesicles and its fluid.

  9. Testicular compartmentalization of Spam1 RNA provides strong support for the lack of sharing hypothesis, and represents a possible mechanism of Spam1-associated transmission ratio distortion .

  10. Mouse SPAM1 and HYAL5 but not HYALP1 (显示 HYAL4 蛋白) proteins exhibit hyaluronidase (显示 HAase 蛋白) activity at neutral pH.

Human Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) interaction partners

  1. Human posterior head 20 (hPH20) and homo sapiens sperm acrosome associated 1 (显示 SPACA1 蛋白) (hSPACA1) immunocontraceptive epitopes reduced fertility in male/female mice.

  2. HSPA2 (显示 HSPA2 蛋白) regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition, such as arylsulfatase A (显示 ARSA 蛋白) and SPAM1.

  3. The interaction between SPAM1, ARSA (显示 ARSA 蛋白) and HSPA2 (显示 HSPA2 蛋白) in a multimeric complex mediating sperm-egg interaction.

  4. PH20 is elevated in demyelinating lesions and that increased PH20 expression is sufficient to inhibit oligodendrocyte precursor cell maturation and remyelination.

  5. SPAM1 mRNA & protein occur in all 3 regions of epididymis & vas (显示 AVP 蛋白) deferens. It has hyaluronidase (显示 HAase 蛋白) activity at pH 7.0. The proximal promoter has epididymal transcription factor sites including androgen receptor (显示 AR 蛋白) elements. Its role may be in sperm maturation.

Cow (Bovine) Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) interaction partners

  1. Bovine testicular hyaluronidase (显示 HAase 蛋白) 3D-model demonstrated lysine residue stratification during enzyme modification.

  2. the effect of metal cations on the transglycosylation by bovine testicular hyaluronidase (显示 HAase 蛋白) using as substrates metal salts of glycosaminoglycan chains was investigated.

  3. results clearly demonstrate that ejaculated bull sperm possess two forms of sperm adhesion molecule 1(SPAM1): one (epididymal) expressed at the surface, and one (testicular) that interacts with the zona pellucida after the acrosome exocytosis.

  4. The hydrolysis Vm values strongly suggest that as the chain length decreases the hyaluronidase (显示 HAase 蛋白) increasingly catalyses transglycosylation rather than hydrolysis.

  5. The simplicity, sensitivity, and versatility of the fluorescent substrate (termed FRET-HA) suggest that it will have utility in a variety of assay platforms and should be a new tool for assessing hyaluronidase (显示 HAase 蛋白) activity.

蛋白简介SPAM1

蛋白简介

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1\; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPAM1

  • sperm adhesion molecule 1 (Spam1)
  • sperm adhesion molecule 1 (SPAM1)
  • sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog (spam1.L)
  • sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1)
  • sperm adhesion molecule 1 (spam1)
  • AV039194 蛋白
  • HYA1 蛋白
  • HYAL1 蛋白
  • HYAL3 蛋白
  • HYAL5 蛋白
  • im:6902904 蛋白
  • PH-20 蛋白
  • PH20 蛋白
  • SPAG15 蛋白
  • Spam 蛋白
  • spam1 蛋白
  • XEH1 蛋白
  • zgc:158668 蛋白

Protein level used designations for SPAM1

hyal-PH20 , hyaluronidase PH-20 , hyaluronoglucosaminidase PH-20 , sperm surface protein PH-20 , sperm protein PH-20 , PH-20 protein , sperm surface antigen 2B1 , hyaluronidase , sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog , hyaluronidase, zona pellucida binding , sperm adhesion molecule 1

GENE ID SPECIES
20690 Mus musculus
100135624 Cavia porcellus
6677 Homo sapiens
100009391 Oryctolagus cuniculus
117037 Rattus norvegicus
398285 Xenopus laevis
353352 Bos taurus
791203 Danio rerio
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