SPACA1 抗体
(Sperm Acrosome Associated 1 (SPACA1))
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008].
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Latest Publications for our SPACA1 抗体
: "Case report of apoptosis in testis of four AZFc-deleted patients: increased DNA fragmentation during meiosis, but decreased apoptotic markers in post-meiotic germ cells." in: Human reproduction (Oxford, England), Vol. 27, Issue 7, pp. 1939-45, (2012) (PubMed).: "Complete deletion of the AZFb interval from the Y chromosome in an oligozoospermic man." in: Human reproduction (Oxford, England), Vol. 25, Issue 10, pp. 2655-63, (2010) (PubMed).
Aliases for SPACA1 抗体
sperm acrosome associated 1 (SPACA1) 抗体sperm acrosome associated 1 (Spaca1) 抗体
1700124L11Rik 抗体
4930540L03Rik 抗体
SAMP32 抗体
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