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SP7 encodes a member of the Sp subfamily of Sp/XKLF transcription factors. 再加上，我们可以发SP7 试剂盒 (26) 和 SP7 蛋白 (4)和数多这个蛋白质的别的产品。
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Human Polyclonal SP7 Primary Antibody for IF (p), IHC (p) - ABIN737811
Chen, Lazarenko, Zhang, Blackburn, Ronis, Badger: Diet-derived phenolic acids regulate osteoblast and adipocyte lineage commitment and differentiation in young mice. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014
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Cow (Bovine) Polyclonal SP7 Primary Antibody for IHC, WB - ABIN2777381
Milona, Gough, Edgar: Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells. in BMC genomics 2004
Results provide evidence that CBP (显示 CREBBP 抗体)-mediated acetylation and HDAC4 (显示 HDAC4 抗体)-mediated deacetylation have critical roles in the modification of Osx (显示 MID1 抗体), and thus are important in osteoblast differentiation.
Osterix and RUNX2 (显示 RUNX2 抗体) are transcriptional regulators of sclerostin (显示 SOST 抗体) in human bone
Osterix decreased the chemosensitivity of breast cancer cells by upregulating the expression of GALNT14 (显示 GALNT14 抗体), which eventually suppressed the apoptosis of breast cancer cells.
TP(thymidine phosphorylase (显示 TYMP 抗体) ) curbed the expression of three proteins-IRF8 (显示 IRF8 抗体), RUNX2 (显示 RUNX2 抗体), and osterix. This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体) signaling and increased the methyltransferase DNMT3A's expression
dissection of these interconnected epigenetic mechanisms that govern Sp7 gene activation reveals a hierarchical process where regulatory components mediating DNA demethylation play a leading role
SP7 gene promoter is robustly enriched in epigenetic repressive marks that may explain its poor transcriptional response to osteoblast differentiating media in umbilical cord derived mesenchymal stem cells.
Eight and five of the nine samples were negative for cell adhesion molecule 1 (显示 CADM1 抗体) and Osterix respectively. The other markers showed no statistical significance(CD151 (显示 CD151 抗体),ALP (显示 ALP 抗体)). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 (显示 CADM1 抗体) could be a useful marker for identifying this phenomenon in carcinoma tissues
The results suggest that Osterix plays an important role in increasing BMP- 4 (显示 BMP4 抗体)-induced Cx43 (显示 GJA1 抗体) activity.
The expression of specific targets Smad1 (显示 GARS 抗体) and Osterix was significantly increased in the presence of Pi and restored by coincubation with Mg(2 (显示 MUC7 抗体)+). As miR (显示 MLXIP 抗体)-30b, miR (显示 MLXIP 抗体)-133a, and miR (显示 MLXIP 抗体)-143 are negatively regulated by Pi and restored by Mg(2 (显示 MUC7 抗体)+) with a congruent modulation of their known targets Runx2 (显示 RUNX2 抗体), Smad1 (显示 GARS 抗体), and Osterix, our results provide a potential mechanistic explanation of the observed upregulation of these master switches of o
Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Runx2 (显示 RUNX2 抗体)-Osterix-BSP (显示 KLK6 抗体) Signaling.
Sp7 plays a critical role in limiting the level of signaling and the rate of bone growth
FGF and Wnt (显示 WNT2 抗体)/beta-Catenin (显示 CTNNB1 抗体) pathways act in part by directing transcription of osx to promote osteoblast differentiation at sites of bone formation.
Data show the endogenous sp7 gene expression in the otic placode and vesicle, and in forming skeletal structures in Tg(sp7:EGFP)b1212 line.
These results suggest proliferation and maturation of immature osteoblasts requires Tgfbr2 (显示 TGFBR2 抗体) signaling and that decreased bone volume in Osx-Cre;Tgfbr2 (显示 TGFBR2 抗体)(fl/fl (显示 FLT3LG 抗体)) mice is likely due to fewer mature osteoblasts.
DNA damage and senescence in osteoprogenitors expressing Osx may cause their decrease with age.
The data support a model in which Dlx recruitment of Sp7 to osteoblast enhancers underlies Sp7-directed osteoblast specification.
Mmp13 (显示 MMP13 抗体) is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (显示 PTH 抗体), and Osterix through distal enhancers.
These results indicated that olfactory bulb development was not significantly impaired in the absence of Osx.
Wnt3a (显示 WNT3A 抗体) induces Osx expression via p38 MAPK (显示 MAPK14 抗体) signaling in dental follicle cells. Wnt3a (显示 WNT3A 抗体)-induced Osx expression was inhibited in the presence of p38 mitogen-activated protein kinase (显示 MAPK14 抗体) (MAPK (显示 MAPK1 抗体)) inhibitors (SB203580 and SB202190) at gene and protein levels, as assessed by real-time PCR and immunocytohistochemistry, respectively.
Transfection assay demonstrated that Osx was able to activate Bsp (显示 KLK6 抗体) promoter reporter in a dose-dependent manner. To define minimal region of Bsp (显示 KLK6 抗体) promoter activated by Osx, a series of deletion mutants of Bsp (显示 KLK6 抗体) promoter were generated, and the minimal region was narrowed down to the proximal 100 bp. Point-mutagenesis studies showed that one GC-rich (显示 RELB 抗体) site was required for Bsp (显示 KLK6 抗体) promoter activation by Osx.
OSX served a key role in the development and progression of ALD (显示 ABCD1 抗体)-induced VSMC calcification. This observation may aid in the explanation of the role of OSX in the pathogenesis of vascular calcification
results suggest that expression of Sp7 during the early stage of Satb2 (显示 SATB2 抗体)-induced osteogenic differentiation of BMSCs is regulated by miR (显示 MLXIP 抗体)-27a.
Fibrillin-2 (显示 FBN2 抗体) and periostin (显示 POSTN 抗体) are target genes in Osterix-mediated osteoblast differentiation.
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.
transcription factor Sp7
, zinc finger protein osterix
, transcription factor osterix
, Sp7 transcription factor
, transcription factor Sp7-like
, trans-acting transcription factor 7
, Sp7 transcription factor 7