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SP7 encodes a member of the Sp subfamily of Sp/XKLF transcription factors. 再加上，我们可以发SP7 试剂盒 (26) 和 SP7 蛋白 (7)和数多这个蛋白质的别的产品。
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Human Polyclonal SP7 Primary Antibody for IF (p), IHC (p) - ABIN737811
Chen, Lazarenko, Zhang, Blackburn, Ronis, Badger: Diet-derived phenolic acids regulate osteoblast and adipocyte lineage commitment and differentiation in young mice. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014
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Cow (Bovine) Polyclonal SP7 Primary Antibody for IHC, WB - ABIN2777381
Milona, Gough, Edgar: Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells. in BMC genomics 2004
Data support a model wherein p53 (显示 TP53 抗体) represses OSX (显示 MID1 抗体)-DNA binding and DLX5 (显示 DLX5 抗体)-OSX (显示 MID1 抗体) interaction, and thereby deregulates the osteogenic transcriptional network.
Results showed that blocking miR (显示 MLXIP 抗体)-31 led to an increase in osterix protein in both cell types at day 7, with an increase in osteocalcin (显示 BGLAP 抗体) at day 21, suggesting MSC (显示 MSC 抗体) osteogenesis
Results provide evidence that CBP (显示 CREBBP 抗体)-mediated acetylation and HDAC4 (显示 HDAC4 抗体)-mediated deacetylation have critical roles in the modification of Osx (显示 MID1 抗体), and thus are important in osteoblast differentiation.
Osterix and RUNX2 (显示 RUNX2 抗体) are transcriptional regulators of sclerostin (显示 SOST 抗体) in human bone
Osterix decreased the chemosensitivity of breast cancer cells by upregulating the expression of GALNT14 (显示 GALNT14 抗体), which eventually suppressed the apoptosis of breast cancer cells.
TP(thymidine phosphorylase (显示 TYMP 抗体) ) curbed the expression of three proteins-IRF8 (显示 IRF8 抗体), RUNX2 (显示 RUNX2 抗体), and osterix. This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体) signaling and increased the methyltransferase DNMT3A's expression
dissection of these interconnected epigenetic mechanisms that govern Sp7 gene activation reveals a hierarchical process where regulatory components mediating DNA demethylation play a leading role
SP7 gene promoter is robustly enriched in epigenetic repressive marks that may explain its poor transcriptional response to osteoblast differentiating media in umbilical cord derived mesenchymal stem cells.
Eight and five of the nine samples were negative for cell adhesion molecule 1 (显示 CADM1 抗体) and Osterix respectively. The other markers showed no statistical significance(CD151 (显示 CD151 抗体),ALP (显示 ALP 抗体)). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 (显示 CADM1 抗体) could be a useful marker for identifying this phenomenon in carcinoma tissues
The results suggest that Osterix plays an important role in increasing BMP- 4 (显示 BMP4 抗体)-induced Cx43 (显示 GJA1 抗体) activity.
In zebrafish lacking sp7, attachment bone is never present, independent of the stage of tooth development or fish age, yet replacement is not interrupted. There was abnormal orientation of teeth, and abnormal connection of pulp cavities of predecessor and replacement teeth, arrested dentinogenesis, non-polarization of odontoblasts and only a thin layer of dentin deposition.
Sp7 plays a critical role in limiting the level of signaling and the rate of bone growth
FGF and Wnt (显示 WNT2 抗体)/beta-Catenin (显示 CTNNB1 抗体) pathways act in part by directing transcription of osx to promote osteoblast differentiation at sites of bone formation.
Data show the endogenous sp7 gene expression in the otic placode and vesicle, and in forming skeletal structures in Tg(sp7:EGFP)b1212 line.
Results indicate that Dlx5 (显示 DLX5 抗体) and Runx2 (显示 RUNX2 抗体) are critical factors for the upregulated Osterix expression in shPP2A cells, which is considered to be important for the accelerated osteoblast differentiation in these cells.
Data support a model wherein p53 (显示 TP53 抗体) represses OSX-DNA binding and DLX5 (显示 DLX5 抗体)-OSX interaction, and thereby deregulates the osteogenic transcriptional network.
this study shows that Osterix represses adipogenesis by negatively regulating PPARgamma (显示 PPARG 抗体) transcriptional activity
these findings strongly suggest that TGF-beta (显示 TGFB1 抗体) signaling plays a major role as one of the upstream regulators of Osx in cementoblast differentiation and cementum formation
These results suggest proliferation and maturation of immature osteoblasts requires Tgfbr2 (显示 TGFBR2 抗体) signaling and that decreased bone volume in Osx-Cre;Tgfbr2 (显示 TGFBR2 抗体)(fl/fl (显示 FLT3LG 抗体)) mice is likely due to fewer mature osteoblasts.
DNA damage and senescence in osteoprogenitors expressing Osx may cause their decrease with age.
The data support a model in which Dlx recruitment of Sp7 to osteoblast enhancers underlies Sp7-directed osteoblast specification.
Mmp13 (显示 MMP13 抗体) is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (显示 PTH 抗体), and Osterix through distal enhancers.
These results indicated that olfactory bulb development was not significantly impaired in the absence of Osx.
Wnt3a (显示 WNT3A 抗体) induces Osx expression via p38 MAPK (显示 MAPK14 抗体) signaling in dental follicle cells. Wnt3a (显示 WNT3A 抗体)-induced Osx expression was inhibited in the presence of p38 mitogen-activated protein kinase (显示 MAPK14 抗体) (MAPK (显示 MAPK1 抗体)) inhibitors (SB203580 and SB202190) at gene and protein levels, as assessed by real-time PCR and immunocytohistochemistry, respectively.
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.
transcription factor Sp7
, zinc finger protein osterix
, transcription factor osterix
, Sp7 transcription factor
, transcription factor Sp7-like
, trans-acting transcription factor 7
, Sp7 transcription factor 7