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SNX10 encodes a member of the sorting nexin family. 再加上，我们可以发SNX10 蛋白 (5)和数多这个蛋白质的别的产品。
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In this study, whole exome sequencing (WES) was successfully used in six patients with malignant infantile osteopetrosis (显示 CSF1 抗体) (MIOP) and identified mutations in four MIOP-related genes (CLCN7 (显示 CLCN7 抗体), TCIRG1 (显示 TCIRG1 抗体), SNX10, and TNFRSF11A (显示 TNFRSF11A 抗体)).
supplementation with calcium gluconate rescued mice from the rachitic phenotype and extended life span in global Snx10-deficient mice, suggesting that this may be a life-saving component of the clinical approach to Snx10-dependent human osteopetrosis (显示 CSF1 抗体)
Data suggest Tyr32 and Arg51 in SNX10 are important for protein stability and play critical roles in vacuolation in osteoclasts; mutation Arg16Leu (seen in autosomal recessive osteopetrosis (显示 CSF1 抗体) patients) affects protein-protein interactions of SNX10.
results confirm the involvement of the SNX10 gene in human ARO (显示 CYP19A1 抗体) and identify a new subset with a relatively favorable prognosis as compared to TCIRG1 (显示 TCIRG1 抗体)-dependent cases
Structure of sorting nexin 11 (SNX11 (显示 SNX11 抗体)) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation.
Identification of SNX10 as a new osteopetrosis (显示 CSF1 抗体) associated gene in consanguineous families of Palestinian origin.
SNX10 regulates the ciliary trafficking of Rab8a (显示 RAB8A 抗体), which is a critical regulator of ciliary membrane extension.
SNX10 activity may be involved in the regulation of endosome homeostasis
results first identified the role of SNX10 in MMP9 (显示 MMP9 抗体) trafficking and secretion, and provided an evidence for SNX10 as a possible therapeutic target for bone destructing disease.
SNX10 plays an important role in the bone destruction of collagen-induced arthritis mice.
data disclose a crucial role and novel function for SNX10 in macrophage polarization. Loss of SNX10 function may be a potential promising therapeutic strategy for IBD.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants.
, sorting nexin 10
, sorting nexin 10 L homeolog
, sorting nexin-10B