-
Study in Han Chinese population revealed that rs3755792 and rs7624906 variants at SST in smoking population and rs3755792 in drinking population presented significant association with hypertension incidence. rs6032470 at GHRH had a statistical association with ischemic stroke incidence in smoking population.
-
SST-positive GABAergic neurons were clearly reduced in GABAergic neurons derived from induced pluripotent stem cells of patients with PARK2 mutations.
-
These findings suggest that some of the antiinflammatory effects of SSt against acute pancreatitis may be mediated by reducing the local proinflammatory cytokine secretion in the pancreas
-
Higher levels of circulating N-terminal-prosomatostatin are associated with increased incidence of vascular dementia.
-
Temporal changes in levels of circulating SST mirror the temporal changes in the incidence of migraine, particularly in women. The SST2 receptor agonist octreotide has been used with some success in migraine and cluster headache. Authors suggest that the withdrawal of descending tone in SST-containing neurons, might create a false pain signal and hence the headache of migraine. [Review]
-
By unbiased genome-wide DNA methylation profiling and comprehensive stepwise verification and validation studies using in vitro and patient-derived samples, we identified 3 promising methylation markers (GHSR, SST, and ZIC1) associated with a 3q gain for the detection of cervical (pre)cancer
-
Somatostatin pancreatic Delta cells (D cells) locations have also been confirmed in animals and human [review].
-
Remarkably, the cyclic neuroendocrine peptide somatostatin-14 (SST14) was observed to be the most selectively enriched oligomeric Abeta1-42 binder.
-
This study demonstrated that expression of somatostatin its colocalization with alpha-synuclein in Amygdala in patient with Parkinson disease.
-
These results suggest that the poly-T repeat sequence polymorphism in the promoter of the SST gene is associated with significant variations of blood pressure and could modulate the risk of hypertension, particularly among women.
-
High N-terminal prosomatostatin expression is associated with Cardiovascular Disease and Diabetes.
-
Data show that 6 of 20 primary pancreatic neuroendocrine tumors (PNETs) had positive staining for multiple hormones gastrin, insulin, glucagon, and somatostatin, and positive expression of 1 or more hormones was found in 9 of 12 nonfunctioning PNETs [NF-PNETs]) patients.
-
Patients with chronic pancreatitis were found to have a strong immunohistochemical reaction to somatostatin and changes in the distribution of D cells when compared to healthy patients.
-
Results suggest that DNA methylation may be a proximal mechanism for decreased expression of BDNF, SST, and other BDNF- and GABA-related genes with brain aging and, by extension, for brain disorders in which their expression is decreased
-
In cancerous colonic mucosa promoter hypermethylation-related SST downregulation may contribute to the uncontrolled cell proliferation.
-
Aberrant methylation inactivates somatostatin and SSTR1 in head and neck squamous cell carcinoma.
-
Distribution of peptidergic populations in the human dentate gyrus (somatostatin [SOM-28, SOM-12] and neuropeptide Y [NPY]) during postnatal development.
-
The aim of the study was to provide knowledge on somatostatin and its action on the body, particularly the pancreas - in physiological and pathological conditions--{REVIEW}
-
Somatostatin and insulin together are critical paracrine mediators of glucose-inhibited glucagon secretion and function by lowering cAMP/PKA signaling with increasing glucose.
-
No somatostatin promoter hypermethylation was detected in the Alzheimer neocortex.