anti-Somatostatin (SST) 抗体

Human Somatostatin (SST) interaction partners

1. Study in Han Chinese population revealed that rs3755792 and rs7624906 variants at SST in smoking population and rs3755792 in drinking population presented significant association with hypertension incidence. rs6032470 at GHRH had a statistical association with ischemic stroke incidence in smoking population.

2. SST-positive GABAergic neurons were clearly reduced in GABAergic neurons derived from induced pluripotent stem cells of patients with PARK2 mutations.

3. These findings suggest that some of the antiinflammatory effects of SSt against acute pancreatitis may be mediated by reducing the local proinflammatory cytokine secretion in the pancreas

4. Higher levels of circulating N-terminal-prosomatostatin are associated with increased incidence of vascular dementia.

5. Temporal changes in levels of circulating SST mirror the temporal changes in the incidence of migraine, particularly in women. The SST2 receptor agonist octreotide has been used with some success in migraine and cluster headache. Authors suggest that the withdrawal of descending tone in SST-containing neurons, might create a false pain signal and hence the headache of migraine. [Review]

6. By unbiased genome-wide DNA methylation profiling and comprehensive stepwise verification and validation studies using in vitro and patient-derived samples, we identified 3 promising methylation markers (GHSR, SST, and ZIC1) associated with a 3q gain for the detection of cervical (pre)cancer

7. Somatostatin pancreatic Delta cells (D cells) locations have also been confirmed in animals and human [review].

8. Remarkably, the cyclic neuroendocrine peptide somatostatin-14 (SST14) was observed to be the most selectively enriched oligomeric Abeta1-42 binder.

9. This study demonstrated that expression of somatostatin its colocalization with alpha-synuclein in Amygdala in patient with Parkinson disease.

10. These results suggest that the poly-T repeat sequence polymorphism in the promoter of the SST gene is associated with significant variations of blood pressure and could modulate the risk of hypertension, particularly among women.

11. High N-terminal prosomatostatin expression is associated with Cardiovascular Disease and Diabetes.

12. Data show that 6 of 20 primary pancreatic neuroendocrine tumors (PNETs) had positive staining for multiple hormones gastrin, insulin, glucagon, and somatostatin, and positive expression of 1 or more hormones was found in 9 of 12 nonfunctioning PNETs [NF-PNETs]) patients.

13. Patients with chronic pancreatitis were found to have a strong immunohistochemical reaction to somatostatin and changes in the distribution of D cells when compared to healthy patients.

14. Results suggest that DNA methylation may be a proximal mechanism for decreased expression of BDNF, SST, and other BDNF- and GABA-related genes with brain aging and, by extension, for brain disorders in which their expression is decreased

15. In cancerous colonic mucosa promoter hypermethylation-related SST downregulation may contribute to the uncontrolled cell proliferation.

16. Aberrant methylation inactivates somatostatin and SSTR1 in head and neck squamous cell carcinoma.

17. Distribution of peptidergic populations in the human dentate gyrus (somatostatin [SOM-28, SOM-12] and neuropeptide Y [NPY]) during postnatal development.

18. The aim of the study was to provide knowledge on somatostatin and its action on the body, particularly the pancreas - in physiological and pathological conditions--{REVIEW}

19. Somatostatin and insulin together are critical paracrine mediators of glucose-inhibited glucagon secretion and function by lowering cAMP/PKA signaling with increasing glucose.

20. No somatostatin promoter hypermethylation was detected in the Alzheimer neocortex.

Mouse (Murine) Somatostatin (SST) interaction partners

1. Transcriptional profiling of Somatostatin interneurons in the spinal dorsal horn has been presented.

2. Parvalbumin neurons can act solo whereas most of Somatostatin neurons may act in chorus on Pyramidal cells.

3. We demonstrate a correlation between the morphological and electrophysiological diversity of layer 5 SST interneurons

4. A novel protective role for somatostatin in the survival of mouse pancreatic beta cells has been demonstrated.

5. The results of this studied suggested that SST-interneurons act as local hubs, which are able to control the influx and extent of cortical cross-modal inputs into the deprived cortex.

6. prefrontal cortical parvalbumin and somatostatin expression and cell density increase during adolescence and are modified by BDNF and sex

7. We show that removal of the paracrine influence of SST suppresses the ability of KATP channel blockers or KATP channel ablation to inhibit glucagon release

8. Synapses from somatostatin-expressing interneurons are regulated by NMDA receptors, signaling through R-type calcium channels.

9. The findings reveal a proaddiction adaptive response to chronic nicotine in which nitric oxide and SST are released by a specific CHRNA5-expressing neuronal population to provide retrograde inhibition of the habenula- interpeduncular nucleus circuit and thereby enhance the motivational properties of nicotine.

10. Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice.

11. HIV-1 Tat causes cognitive deficits and selective loss of parvalbumin, somatostatin, and neuronal nitric oxide synthase expressing hippocampal CA1 interneuron subpopulations.

12. Suppressing somatostatin (SOM) neurons enhanced the Excitation and Inhibition underlying size tuning, explaining SOM neurons' role in surround suppression.

13. dendrite-targeting somatostatin interneurons are critical for a visually induced, context-dependent gamma rhythm in visual cortex.

14. The results of this study provided the first in vivo evidence that SOM(+) neurons represent a Central Amygdala population that acquires learning-dependent sensory responsiveness during fear conditioning and furthermore reveal an important role of these neurons in gating passive versus active defensive behaviors.

15. preinspiratory Dbx1 neurons are rhythmogenic, inspiratory Dbx1+ and SST+ neurons primarily act to pattern respiratory motor output, and SST+-neuron-mediated pathways and postsynaptic inhibition modulate breathing pattern. I

16. Endogenous SST and CORT distinctly impact on DMBA-induced mammary gland tumorigenesis , in a manner that is strongly dependent on the metabolic/endocrine milieu (lean vs. obese status).

17. This study demonstrated that Hippocampal Somatostatin Interneurons Control the Size of Neuronal Memory Ensembles.

18. Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic alpha-cells.

19. Data indicate that somatostatin (SST)-secretion is regulated by incretin hormones, cholecystokinin, acetylcholine, vasoactive intestinal polypeptide, calcitonin gene-related polypeptide, oligopetides, and trace amines.

20. Data indicate all gastric mucosa receptors through which somatostatin (SST) secretion is regulated by hormones, neurotransmitters, neuropeptides and metabolites that act directly on the SST cells.

Cow (Bovine) Somatostatin (SST) interaction partners

1. Individuals with genotype AA of somatostatin had significantly lower body height, body length, hip width, and hucklebone width values compared to AG at 1.5 years old

2. The present study, provides evidence of pro-SST and SST receptor (SSTR1 and 2A) mRNA expression in ocular ciliary epithelium (CE).

3. The distribution and morphology of neurons containing somatostatin (SOM) was investigated in the amygdala (CA) of the pig.

4. Data show that PKA and PKC pathways are involved in the differential regulation of production of the neuropeptides (Met)enkephalin, galanin, somatostatin, NPY, and VIP.

Pig (Porcine) Somatostatin (SST) interaction partners

1. demonstrate diverse neuronal, neuroendocrine, and cardiovascular actions of a somatostatin gene-encoded hormone

Rhesus Monkey Somatostatin (SST) interaction partners

1. Study showed that in situ hybridization demonstrated an anterior-posterior gradient of somatostatin mRNA in the lateral central nucleus of the amygdala but not the bed nucleus of the stria terminalis of non-human primates.

2. Somatostatin directly promoted spontaneous contractions of the circular muscle of macaque intestine via mediation of SSTR2 in myenteric nerve plexus between the longitudinal and the circular muscle.

Rabbit Somatostatin (SST) interaction partners

1. Helicobacter pylori is capable of inhibiting acid secretion directly as well as indirectly by activating intramural CGRP sensory neurons coupled to stimulation of SST and inhibition of histamine secretion.