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SLC16A1 encodes a Na+/H+ antiporter that is a member of the solute carrier family 9.
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Study demonstrated that the high mRNA level of both MCT1 and GLUT1 correlated with poor prognosis, high- Fuhrman grade clear-cell renal cell carcinoma and metabolic reprogramming.
Hypoxia-induced MCT1 (显示 CMA1 ELISA试剂盒) supports glioblastoma glycolytic phenotype, being responsible for lactate efflux and an important mediator of cell survival and aggressiveness
our finding that the expression of MCT1 (显示 CMA1 ELISA试剂盒) and MCT4 is reduced in mutant IDH1 (显示 IDH1 ELISA试剂盒) gliomas highlights the unusual metabolic reprogramming that occurs in mutant IDH1 (显示 IDH1 ELISA试剂盒) tumors and has important implications for our understanding of these tumors and their treatment
MCT1 (显示 CMA1 ELISA试剂盒) expression, independent of transporter activity, is required for growth factor-induced tumor cell motility.
TOMM20 (显示 TOMM20 ELISA试剂盒), MCT1 (显示 CMA1 ELISA试剂盒), and MCT4 expression was significantly different in Hodgkin and Reed Sternberg (HRS) cells. HRS have high expression of MCT1 (显示 CMA1 ELISA试剂盒), while tumor associated macrophages have absent MCT1 (显示 CMA1 ELISA试剂盒) expression. Tumor-infiltrating lymphocytes have absent MCT1 (显示 CMA1 ELISA试剂盒) expression. Reactive lymph nodes in contrast to cHL (显示 CHRDL1 ELISA试剂盒) tumors had low TOMM20 (显示 TOMM20 ELISA试剂盒), MCT1 (显示 CMA1 ELISA试剂盒), and MCT4 expression in lymphocytes and macrophages.
TOMM20 (显示 TOMM20 ELISA试剂盒) and MCT1 (显示 CMA1 ELISA试剂盒) were highly expressed in diffuse large B-cell lymphoma lymphocytes, indicating an OXPHOS phenotype, whereas non-neoplastic lymphocytes in the control samples did not express these markers.
MCT1 (显示 CMA1 ELISA试剂盒) inhibitor AZD3965 increased MCT4-dependent accumulation of intracellular lactate, inhibiting monocarboxylate influx and efflux.
Silencing or genetic deletion of MCT1 (显示 CMA1 ELISA试剂盒) in vivo inhibited migration, invasion, and spontaneous metastasis.
The reversible H(+)/lactate(-) symporter MCT1 (显示 CMA1 ELISA试剂盒) cotransports lactate and proton, leading to the net extrusion of lactic acid in glycolytic tumors. A model of its role in pH control in tumor cells is described. Review.
Increased miR (显示 MLXIP ELISA试剂盒)-210 and concomitant decreased ISCU RNA levels were found in ~40% of tumors and this was significantly associated with HIF-1alpha (显示 HIF1A ELISA试剂盒) and CAIX (显示 CA9 ELISA试剂盒), but not MCT1 (显示 CMA1 ELISA试剂盒) or MCT4, over-expression.
Data indicate that monocarboxylate transporters (MCTs1 (显示 MCTS1 ELISA试剂盒)-4) were all found to be expressed in brains of embryos, and were localized in both neurons and astrocyte.
The expression of monocarboxylic acid transporter 1 (MCT1 (显示 MCTS1 ELISA试剂盒)), MCT2 (显示 SLC16A7 ELISA试剂盒), and CD147 in 3 horse breeds with different atheletic demands is reported.[MCT1 (显示 MCTS1 ELISA试剂盒); MCT2 (显示 SLC16A7 ELISA试剂盒)]
Results indicated that a single IET resulted in transient increases in MCT1 (显示 MCTS1 ELISA试剂盒) and MCT4 (显示 SLC16A3 ELISA试剂盒) mRNA expression and protein content in untrained and trained horses.
The coding sequence of MCT1 (显示 MCTS1 ELISA试剂盒), MCT4 (显示 SLC16A3 ELISA试剂盒), and CD147 in healthy horses, and the incidence of polymorphisms of these proteins in horses with excercise-induced myopathy are reported.
MCT1 (显示 MCTS1 ELISA试剂盒) protein content in GMM samples obtained when the horses were 24 months old was significantly higher than at 2 months of age. However, MCT4 (显示 SLC16A3 ELISA试剂盒) protein content remained unchanged throughout the study period.
Silencing or genetic deletion of MCT1 (显示 MCTS1 ELISA试剂盒) in vivo inhibited migration, invasion, and spontaneous metastasis.
It was concluded that both MCT1 (显示 MCTS1 ELISA试剂盒) and CAII (显示 CA2 ELISA试剂盒) are involved in the homeostatic control of pH in skeletal muscle, both at rest and at the onset of exercise. The improved muscle function and resistance to fatigue in MCT1 (显示 MCTS1 ELISA试剂盒)(+/-) mice remain unexplained.
Exercise-induced changes in tumour LDH-B (显示 LDHB ELISA试剂盒) and MCT1 (显示 MCTS1 ELISA试剂盒) expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice
Chronic lactate administration after exercise increases MCT1 (显示 MCTS1 ELISA试剂盒) protein expression, which can be involved in the regulation of the observed increase in muscle glycogen (显示 GYS1 ELISA试剂盒) storage after exercise training.
This study showed that mouse MCT1 (显示 MCTS1 ELISA试剂盒), MCT2 (显示 SLC16A7 ELISA试剂盒), and MCT4 (显示 SLC16A3 ELISA试剂盒) are expressed in the PNS. While DRG neurons express MCT1 (显示 MCTS1 ELISA试剂盒), myelinating Schwann cells.
These data for the first time demonstrate that MCT1 (显示 MCTS1 ELISA试剂盒) is critical for regeneration of both sensory and motor axons in mice following sciatic nerve crush
in Parkinson's disease, the levels of MCT1 (显示 MCTS1 ELISA试剂盒), MCT2 (显示 SLC16A7 ELISA试剂盒) and GLUT1 (显示 SLC2A1 ELISA试剂盒) is not changed following dopaminergic neurodegeneration
results suggest that a reduction in mitochondria is a result, rather than the cause, of the metabolic deficiency observed in Basigin-null mice, and likely occurs because of reduced metabolic activity in the absence of MCT1 (显示 MCTS1 ELISA试剂盒) expression.
miR (显示 MLXIP ELISA试剂盒)-29a, miR (显示 MLXIP ELISA试剂盒)-29b selectively target MCT1 (显示 MCTS1 ELISA试剂盒) 3'UTR (显示 UTS2R ELISA试剂盒) ; the miR (显示 MLXIP ELISA试剂盒)-29 isoforms are highly expressed in islets and contribute to silencing Mct1 (显示 MCTS1 ELISA试剂盒) in beta cells; miR (显示 MLXIP ELISA试剂盒)-29 isoforms contribute to beta-cell-specific silencing of the MCT1 (显示 MCTS1 ELISA试剂盒) transporter and may affect insulin (显示 INS ELISA试剂盒) release
monocarboxylate transporter 1 (MCT1), is highly enriched within oligodendroglia and disruption of this transporter produces axon damage and neuron loss in animal and cell culture models; in addition, this same transporter is reduced in patients with, and in mouse models of, amyotrophic lateral sclerosis, suggesting a role for oligodendroglial MCT1 (显示 MCTS1 ELISA试剂盒) in pathogenesis
This study confirmed age-dependent changes of MCT1 (显示 MCTS1 ELISA试剂盒) expression in the rumen epithelium of newborn calves and showed that its expression might be affected by liquid feed type.
These findings show that MCT 1 (显示 MCTS1 ELISA试剂盒) increases with the development of rumen function and also in adult animals MCT 1 (显示 MCTS1 ELISA试剂盒) may change with the feeding.
The expression and distribution of monocarboxylate transporter 1 along the gastrointestinal tract of calves suggest it may play a role in transport of short chain fatty acids and their metabolites.
The results show that monocarboxylate transporter 1 (MCT1) is a major route for short chain fatty acids (SCFA) efflux across the basolateral membrane of bovine large intestine and that it could play a role in the regulation of intracellular pH.
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.
, monocarboxylate transporter 1
, solute carrier family 16 (monocarboxylic acid transporters), member 1
, solute carrier family 16 member 1
, solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
, monocarboxylate transporter 1a
, monocarboxylate transporter 1-like
, solute carrier 16 (monocarboxylic acid transporter), member 1
, Monocarboxylate transporter 1
, monocarboxylate transporter 1-like protein
, solute carrier family 16 (monocarboxylate transporter), member 1