anti-Sodium Dependent Vitamin C Transporter 1 (SVCT1) 抗体

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. 再加上,我们可以发Sodium Dependent Vitamin C Transporter 1 试剂盒 (6)Sodium Dependent Vitamin C Transporter 1 蛋白 (3)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
SVCT1 9963 Q9UHI7
SVCT1 20522 Q9Z2J0
SVCT1 50621 Q9WTW7
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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 IHC (p), WB SLC23A1 Antibdy (N-term) (ABIN656646) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. All lanes : Anti-SLC23A1 Antibody (N-term) at 1:1000-1:2000 dilution Lane 1: Caki-1 whole cell lysate Lane 2: HT-29 whole cell lysate Lane 3: SW480 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 65 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:1000-1:2000 400 μL Log in to see 10至11个工作日
$385.00
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非结合性 WB Western blot analysis of extract of various cells, using SLC23A1 antibody. Western blot analysis of extracts of various cell lines, using SLC23A1 antibody (ABIN4905185) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s. 100 μL Log in to see 11至13个工作日
$366.77
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非结合性 IHC, ELISA, WB   200 μL Log in to see 11至16个工作日
$658.43
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HRP IHC, ELISA, WB   200 μL Log in to see 11至14个工作日
$1,101.83
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Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL Log in to see 11至14个工作日
$1,101.83
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Biotin IHC, ELISA, WB   200 μL Log in to see 11至14个工作日
$1,101.83
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FITC IHC, ELISA, WB   200 μL Log in to see 11至14个工作日
$1,101.83
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APC IHC, ELISA, WB   200 μL Log in to see 11至14个工作日
$1,101.83
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PE IHC, ELISA, WB   200 μL Log in to see 11至14个工作日
$1,101.83
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非结合性 IHC, IHC (p), WB   400 μL Log in to see 11至14个工作日
$493.17
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引用最多的anti-Sodium Dependent Vitamin C Transporter 1 抗体

  1. Human Polyclonal SVCT1 Primary Antibody for IHC (p), WB - ABIN656646 : Subramanian, Nabokina, Patton, Marchant, Moradi, Said: Glyoxalate reductase/hydroxypyruvate reductase interacts with the sodium-dependent vitamin C transporter-1 to regulate cellular vitamin C homeostasis. in American journal of physiology. Gastrointestinal and liver physiology 2013 (PubMed)

  2. Human Polyclonal SVCT1 Primary Antibody for IHC, IHC (p) - ABIN4354115 : Subramenium, Sabui, Marchant, Said, Subramanian: Enterotoxigenic Escherichia coli heat labile enterotoxin inhibits intestinal ascorbic acid uptake via a cAMP-dependent NF-κB-mediated pathway. in American journal of physiology. Gastrointestinal and liver physiology 2019 (PubMed)

更多抗Sodium Dependent Vitamin C Transporter 1的相互作用对抗体

Human Sodium Dependent Vitamin C Transporter 1 (SVCT1) interaction partners

  1. Our findings show, for the first time, that transporters of the water-soluble vitamin ascorbic acid (i.e., the vitamin C transporters SVCT-1 and SVCT-2) are differentially expressed along the length of the intestinal tract and that the pattern of expression is mediated, at least in part, by transcriptional and epigenetic mechanism(s) affecting both Slc23a1 and Slc23a2 genes.

  2. consensus site for HNF1 that is crucial for the regulation of the human SVCT1 promoter is present in the SVCT1 rat promoter but has no effect on its transcriptional activity

  3. SNP rs6596473 of SLC23A1 is suggested to be associated with AgP. results add to previous reports vitamin C plays a role in pathogenesis of periodontitis.

  4. Data from observational/genetic association studies in Europe suggest an SNP in SLC23A1 (rs33972313) is associated with up-regulation of circulating L-ascorbic acid but not with any cardiometabolic/cardiovascular outcome investigated. [META-ANALYSIS]

  5. The SVCT1 was induced and localized to the apical membrane of tubular epithelial cells.

  6. polymorphisms in SLC23A1/2 genes influenced ascorbate concentration in aqueous humor and lens nucleus.

  7. A genetic variant in the SLC23A1 ascorbate transporter locus was identified and is associated with an increased risk of Crohn disease in a white Canadian inflammatory bowel diseases cohort.

  8. Data show that the mRNA level of svct2 was approximately 600- to 900-fold higher than that of svct1 indicating SVCT2 is a main isoform in fibroblast OUMS-36 cells, and no significant difference in svct2 mRNA and protein between young and old cells.

  9. Data suggest that N-terminal and C-terminal sorting signals interact, directly or indirectly, within each gene family (here, SVCT1 and SVCT2) in basolateral targeting of transmembrane proteins to basolateral cell membrane.

  10. SVCT1 directly interacts with GRHPR.

  11. These findings show a role for Rab8a in the physiological function of SVCT1 in intestinal epithelia.

  12. glutathione depletion failed to affect ascorbic acid transport, and SVCT1 and SVCT2 expression in hepatoma cells. Therefore, our data indicate an essential role for glutathione in controlling vitamin C metabolism in rat hepatocytes and rat hepatoma cells

  13. In patients with hepatocellular cholestasis, primary biliary cirrhosis, haemochromatosis and non-alcoholic steatohepatitis, using real-time RT-PCR, an enhanced hepatic expression of both SLC23A1 and SLC23A2 was found.

  14. hSVCT1 and 2 promoters establish that ascorbic acid uptake by human liver epithelial cells is adaptively regulated and show that transcriptional mechanisms via HNF-1 in the hSVCT1 promoter may, in part, be involved in this regulation.

  15. A genetic variant (rs33972313) in the SLC23A1 vitamin C active transporter locus was identified that is reliably associated with circulating concentrations of L-ascorbic acid in the general population.

  16. SVCT1 is the transporter that allows vectorial uptake of ascorbic acid in differentiated CaCo-2 cells

  17. Results provide the first direct resolution of functional hSVCT1 expression at the apical cell surface of polarized epithelia and define an apical targeting signal of relevance to transporters of diverse substrate specificity.

  18. Functionally, SVCT1 expression led to more transport activity from the apical membrane, while SVCT2 expression only increased the uptake under the condition when basolateral membrane was exposed.

  19. Findings link genetic variants in the vitamin C transporter gene SLC23A1 to spontaneous preterm birth.

  20. C uptake is increased in UVB-irradiated keratinocytes through the translocation of SVCT-1 and regulates inflammatory response in the skin via the downregulation of IL-8 and MCP-1 production

Mouse (Murine) Sodium Dependent Vitamin C Transporter 1 (SVCT1) interaction partners

  1. Aging modulates vitamin C transporter expression. Renal over-expression of SVCT1 enhances vitamin C reabsorption in aged animals that may synthesize less vitamin C.

  2. The SVCT1 was induced and localized to the apical membrane of tubular epithelial cells.

  3. a key role for Slc23a1 in renal ascorbate absorption and perinatal survival and reveal regulation of vitamin C biosynthesis in mice.

  4. By using primary cultured hepatocytes from SMP30/GNL KO mice, we found that SVCT1 and SVCT2 mRNA expression levels and AA uptake ability were significantly enhanced in the hepatocytes of ascorbic acid-depleted SMP30/GNL KO mice.

  5. SVCT2 is major determinant of ascorbate accumulation in tissues lacking SVCT1. SVCT isoforms appear to function independently of one another. SVCT1 expression and ascorbate concentrations in SVCT1-predominant organs were not affected by SVCT2 deficiency.

  6. SVCT1 is responsible for epidermal ascorbic acid supply, whereas SVCT2 mainly facilitates ascorbic acid transport in the dermal compartment

  7. PPARalpha up-regulates the expression of Slc23a1 in small intestine.

  8. This work describe the molecular identity of the transporters involved in vitamin C transport in Sertoli cells.

Sodium Dependent Vitamin C Transporter 1 (SVCT1) 抗原简介

蛋白简介

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SVCT1

  • solute carrier family 23 member 1 (SLC23A1) 抗体
  • solute carrier family 23 (nucleobase transporters), member 1 (Slc23a1) 抗体
  • solute carrier family 23 member 1 (Slc23a1) 抗体
  • D18Ucla2 抗体
  • Slc23a2 抗体
  • SVCT1 抗体
  • YSPL3 抗体

Protein level used designations for SVCT1

Na(+)/L-ascorbic acid transporter 1 , hSVCT1 , sodium-dependent vitamin C transporter 1 , sodium-dependent vitamin C transporter-1 , solute carrier family 23 (nucleobase transporters), member 1 , solute carrier family 23 (nucleobase transporters), member 2 , solute carrier family 23 member 1 , yolk sac permease-like molecule 3 , sodium-coupled ascorbic acid transporter 1 , sodium-coupled ascorbic acid transporter 1

GENE ID SPECIES
9963 Homo sapiens
20522 Mus musculus
50621 Rattus norvegicus
396578 Sus scrofa
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