Signaling Lymphocytic Activation Molecule Family Member 1 蛋白 (SLAMF1)

Mouse (Murine) Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) interaction partners

1. the Slam locus has an overall inhibitory role during NK cell activation that is solely dependent on 2B4 (显示 CD244 蛋白). This effect is influenced by cytokines and leads to suppression of LFA-1 (显示 ITGAL 蛋白) activity.

2. CRISPR-Mediated Slamf1Delta/Delta Slamf5Delta/Delta Slamf6Delta/Delta Triple Gene Disruption Reveals NKT (显示 CTSL1 蛋白) Cell Defects but Not T Follicular Helper Cell Defects.

3. We demonstrated that Bacille Calmette-Guerin infection significantly upregulated SLAMF1, which enhanced inflammatory response by activating the NF-kappaB (显示 NFKB1 蛋白) signaling pathway and facilitated bacterial clearance in BCG (显示 SLC11A1 蛋白)-infected RAW264.7 cells and mice.

4. Slamf1 and Slamf8 (显示 SLAMF8 蛋白) govern ROS (显示 ROS1 蛋白)-dependent innate immune responses of myeloid cells.

5. The combined effects of RIIB deletion and pathogenic SLAM can lead to severe lupus nephritis in the B6 genetic background.

6. SLAM-SAP (显示 APCS 蛋白) signaling promotes differentiation of IL-17 (显示 IL17A 蛋白)-producing T cells and progression of experimental autoimmune encephalomyelitis.

7. The goal of the current study was to determine whether Slam haplotype affected NKT (显示 CTSL1 蛋白) and Vgamma4+ T-cell responses subsequent to coxsackievirus b3 infection.

8. Signaling lymphocyte activation molecule regulates development of colitis in mice.

9. Slamf1, which controls phagosomal/lysosomal fusion and phagosomal NADPH-oxidase (显示 NOX1 蛋白) activity, is required for T.cruzi replication in macrophages and dendritic cells, but not in other cells, which do not express the receptor.

10. conclude that Slamf1 recruits a subset of Vps34 (显示 PIK3C3 蛋白)-associated proteins, which is involved in membrane fusion and NOX2 (显示 CYBB 蛋白) regulation

Human Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) interaction partners

1. CD150 and CD180 (显示 CD180 蛋白) receptors may modulate transcriptional program in lymphocytic leukemia cells by regulating the transcription factor expression levels

2. this paper shows that the X-linked lymphoproliferative disease gene product SAP (显示 APCS 蛋白) regulates signals induced through the co-receptor SLAM

3. combination of signals via CD150 and CD180 (显示 CD180 蛋白) leads to blocking of pro-survival pathways that may be a restraining factor for neoplastic CLL B cells propagation in more than 50% of CLL cases where these receptors are coexpressed

4. EBF1 (显示 EBF1 蛋白) is critical for transcriptional control of SLAMF1 gene in human B cells.

5. MeV can hijack SLAMF1 to drive endocytosis using a complex pathway that shares features with canonical viral macropinocytosis, phagocytosis, and mechanotransduction. This uptake pathway is specific to SLAMF1-positive cells and occurs within 60 min of viral attachment.

6. Malignant B-cell lines at the different stages of maturation only partially resemble their normal counterparts by CD150 expression. In malignant B-cell lines, CD150 expression on mRNA level is much broader than on protein level. CD150 isoforms are differentially expressed in normal and malignant B cells with predominant expression of mCD150 isoform.

7. Data suggest that SLAMF1 is another significant piece in the intricate defective immune-regulatory function of patients with SLE.

8. results indicate that loss of SLAMF1 expression in chronic lymphocytic leukemia modulates genetic pathways

9. Upstream open reading frames regulate translation of the long isoform of SLAMF1 mRNA that encodes costimulatory receptor CD150

10. Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP (显示 APCS 蛋白) exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM peptide.