Sialic Acid Binding Ig-Like Lectin 11 (SIGLEC11) ELISA试剂盒

SIGLEC11 encodes a member of the sialic acid-binding immunoglobulin-like lectin family. 再加上,我们可以发SIGLEC11 抗体 (60)SIGLEC11 蛋白 (3)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
SIGLEC11 114132 Q96RL6
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Human Sialic Acid Binding Ig-Like Lectin 11 (SIGLEC11) interaction partners

  1. The authors demonstrated that the human-specific pathogen Escherichia coli K1 uses its polysialic acid capsule as a molecular mimic to engage Siglec-11 and escape killing. In contrast, engagement of the activating counterpart Siglec-16 increases elimination of bacteria.

  2. The results indicate potential roles for Siglec-11 in ovarian physiology and human evolution.

  3. Siglec-11 ectopically expressed on murine microglia interacts with PSA on neurons, reduces LPS-induced gene transcription of proinflammatory mediators, impairs phagocytosis and alleviates microglial neurotoxicity.

  4. cloning and characterization; a recently evolved signaling that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages including brain microglia

  5. expressed in human but not in chimpanzee brain microglia; findings indicate that human SIGLEC11 emerged through human-specific gene conversion by an adjacent pseudogene

  6. SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.

SIGLEC11 抗原简介

Antigen Summary

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SIGLEC11

  • sialic acid binding Ig like lectin 11 (SIGLEC11) 抗体

Protein level used designations for SIGLEC11

sialic acid-binding Ig-like lectin 11 , siglec-11 , sialic acid binding Ig-like lectin 11 , sialic acid-binding Ig-like lectin 11-like

GENE ID SPECIES
114132 Homo sapiens
747721 Pan troglodytes
100387822 Callithrix jacchus
100447534 Pongo abelii
100605002 Nomascus leucogenys
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