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SLPI encodes a secreted inhibitor which protects epithelial tissues from serine proteases. 再加上，我们可以发SLPI 抗体 (116) 和 SLPI 试剂盒 (45)和数多这个蛋白质的别的产品。
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we show that SLPI acts as a key mediator in regulating the function of hepatic myeloid cells, to promote resolution responses through induction of MerTK (显示 MERTK 蛋白) expression within the resident macrophage population.
these data demonstrate increased anti-inflammatory activity of the SLPI-A16G protein compared with SLPI-WT in a murine model of pulmonary Pseudomonas infection
we demonstrated that the oncogenic effect of SLPI may be due to protection of growth factor progranulin (显示 GRN 蛋白) from enzymatic cleavage or suppression of castration-resistant prostate cancer (CRPC)cell apoptosis independent of anti-protease activity of SLPI. These findings implicate SLPI as a potential biomarker of resistance to AR inhibition and therapeutic target for CRPC treatment
Secretory leukocyte protease inhibitor mediates invasiveness of oral carcinoma cells.
The results indicate that SERPINE2 (显示 SERPINE2 蛋白) and SLPI play a significant role in the development of papillary thyroid cancer and imply that the evaluation of serum concentrations of both anticoagulant molecules may be considered as additional marker for the differentiation of malignancies during the preoperative diagnosis of patients with thyroid gland tumors.
Bronchial epithelial cells have decreased SLPI expression in response to hypoxia.
Ongoing herpes simplex virus infection and resultant downregulation of local levels of SLPI may impart a greater susceptibility for keratinocytes to human papillomavirus type 16 infection through the host cell receptor annexin A2 (显示 ANXA2 蛋白).
SLPI is an independent predictor for both OS and DSS (显示 NR0B1 蛋白) and a relevant prognostic biomarker in OSCC.
The elevations in cervical elafin (显示 PI3 蛋白) and SLPI expression in the women with preterm delivery might reflect the local response to the pathogen invasion into the cervix preceding preterm labor.
These results demonstrate that SLPI down-regulates pIgR (显示 PIGR 蛋白) expression through the NF-kappaB (显示 NFKB1 蛋白) signaling pathway by inhibiting degradation of IkappaBbeta (显示 NFKBIB 蛋白) protein.
MIF-2 (显示 HSPA5 蛋白)/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI- and ATF4 (显示 ATF4 蛋白)-dependent mechanisms.
Slpi(-/-) mice had impaired collagen gene expression but animals demonstrated minimal reduction in lung fibrosis compared with wild-type animals. These data suggest that enhanced proteolysis does not further enhance TGF-beta (显示 TGFB1 蛋白) activation, and inhibits sustained Col1alpha1, Col3alpha1, and Col4alpha1 gene expression following lung injury.
Data show that differentiative switches between bronchiolar progenitors and club cells are under the Nrf2 (显示 NFE2L2 蛋白)-mediated control of SLPI and syndecan 4 (显示 SDC4 蛋白).
study identifies a distinct immune response in SA characterized by a dysregulated IFN-gamma (显示 IFNG 蛋白)/SLPI axis that affects lung function.
Studied the function of Secretory Leukocyte Protease Inhibitor (SLPI) in odontoblast during mouse tooth development.
Data show that the expression of several genes encoding salivary antimicrobial proteins, such as secretory leukocyte peptidase inhibitor (SLPI), S100A8 (显示 S100A8 蛋白), and lactotransferrin (显示 LTF 蛋白), was reduced due to myeloid differentiation dactor 88 (MyD88 (显示 MYD88 蛋白)) deficiency.
a possible role for SLPI in enhancing the metastatic behavior of breast cancer cell line 4T1
These studies define an important role for SLPI in innate and adaptive immunity and offer new insight into strategies for the use of this naturally occurring molecule in the modulation of infectious and inflammatory diseases.
In experimental autoimmune encephalomyelitis, SLPI exerts potent pro-inflammatory actions by modulation of T-cell activity
The results underscore the importance of SLPI as a modulator of specific immunity that can also function at peripheral sites under pathogenic pressure.
This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes\; the protein is also thought to have broad-spectrum anti-biotic activity.
, matrilin 4
, secretory leukocyte peptidase inhibitor
, WAP four-disulfide core domain protein 4
, mucus proteinase inhibitor
, protease inhibitor WAP4
, secretory leukocyte protease inhibitor (antileukoproteinase)
, seminal proteinase inhibitor
, secretory leukocyte protease inhibitor