anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) 抗体

SLPI encodes a secreted inhibitor which protects epithelial tissues from serine proteases. 再加上,我们可以发SLPI 试剂盒 (52)SLPI 蛋白 (18)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
SLPI 6590 P03973
SLPI 20568 P97430
SLPI 84386  
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Showing 10 out of 115 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 WB <b>WB Suggested Anti-SLPI Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>Human heart WB Suggested Anti-SLPI <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 <br /> Positive Control: Human heart 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 ELISA, IHC (p), WB Western blot analysis of SLPI using anti-SLPI antibody . Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.  Lane 1: human A549 whole cell lysates, Lane 2: human U2OS whole cell lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-SLPI antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 ug/mL overnight at 4℃, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for SLPI at approximately 14KD. The expected band size for SLPI is at 14KD. IHC analysis of SLPI using anti-SLPI antibody .SLPI was detected in paraffin-embedded section of human lung cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1ug/ml rabbit anti-SLPI Antibody  overnight at 4℃. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37℃. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg Log in to see 4至6个工作日
$280.00
详细
非结合性 IHC, IHC (p), WB Immunohistochemistry-Paraffin: SLPI Antibody [NBP1-89139] - Staining of human nasopharynx shows strong cytoplasmic positivity in subsets of respiratory epithelial cells. Western Blot: SLPI Antibody [NBP1-89139] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY418925) 0.1 mL Log in to see 10至13个工作日
$491.63
详细
小鼠 非结合性 ELISA, IHC, IHC (fro), IHC (p), IP, WB Anti-ALK1 / SLPI antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:25. 50 μg Log in to see 11至14个工作日
$727.83
详细
小鼠 Biotin EIA, IHC (fro), IHC (p), WB 50 μg Log in to see 6至8个工作日
$412.50
详细
小鼠 非结合性 EIA, WB   0.1 mg Log in to see 8至11个工作日
$474.10
详细
非结合性 WB SLPI Antibody (Center)  western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SLPI antibody detected the SLPI protein (arrow). 400 μL Log in to see 10至11个工作日
$335.50
详细
小鼠 非结合性 EIA, IHC (fro), IHC (p), IP, WB 0.1 mg Log in to see 6至8个工作日
$632.50
详细
非结合性 EIA, IHC (p), WB   0.1 mg Log in to see Available
$474.10
详细
小鼠 非结合性 ELISA, WB   100 μg Log in to see 15至19个工作日
$523.71
详细

引用最多的anti-SLPI 抗体

  1. Human Monoclonal SLPI Primary Antibody for FACS, IP - ABIN2191907 : Wingens, van Bergen, Hiemstra, Meis, van Vlijmen-Willems, Zeeuwen, Mulder, Kramps, van Ruissen, Schalkwijk: Induction of SLPI (ALP/HUSI-I) in epidermal keratinocytes. in The Journal of investigative dermatology 1999 (PubMed)
    Show all 6 Pubmed References

  2. Human Monoclonal SLPI Primary Antibody for FACS, IP - ABIN2191906 : Nakao, Hanada, Asano, Hara, Abdus Salam, Matin, Shimazu, Nakasone, Horibata, Aoba, Honda, Amagasa, Senpuku: Assessment of oral transmission using cell-free human immunodeficiency virus-1 in mice reconstituted with human peripheral blood leucocyte. in Immunology 2003 (PubMed)
    Show all 6 Pubmed References

  3. Mouse (Murine) Polyclonal SLPI Primary Antibody for ELISA, WB - ABIN1003159 : Abe, Kobayashi, Yoshimura, Trapnell, Kim, Hubbard, Brewer, Thompson, Crystal: Expression of the secretory leukoprotease inhibitor gene in epithelial cells. in The Journal of clinical investigation 1991 (PubMed)
    Show all 4 Pubmed References

  4. Human Polyclonal SLPI Primary Antibody for IHC, ELISA - ABIN1003158 : Jana, Gray, Shugars: Human immunodeficiency virus type 1 stimulates the expression and production of secretory leukocyte protease inhibitor (SLPI) in oral epithelial cells: a role for SLPI in innate mucosal immunity. in Journal of virology 2005 (PubMed)
    Show all 4 Pubmed References

更多抗SLPI的相互作用对抗体

Human Secretory Leukocyte Peptidase Inhibitor (SLPI) interaction partners

  1. we investigated the biological effects of SLPI using Cell Counting Kit (CCK)-8 (显示 CCK 抗体), Annexin V (显示 ANXA5 抗体)/PI apoptosis assay and Caspase (显示 CASP3 抗体)-Glo(R) 3/7 assay. The findings revealed that SLPI promoted apoptosis in the Leuk1 and WSU-HN4 cell lines. Mechanistic studies indicated that SLPI, at least in part, regulated cell apoptosis by inhibiting the expression of TNF receptor-associated factor 1 (显示 TRAF1 抗体)

  2. Together, these data support the clinical evaluation of dual angiogenic inhibition of the ALK1 (显示 ACVRL1 抗体) and VEGF (显示 VEGFA 抗体) pathways in patients with advanced renal cell carcinoma (显示 MOK 抗体) (RCC (显示 XRCC1 抗体)) .

  3. the patients with systemic sclerosis had significantly increased serum levels of SLPI in comparison with the rheumatoid arthritis patients and the healthy controls

  4. gene expression profiling study based on microarray data for the three cell types identified a number of candidates, including LCP1 (显示 LCP1 抗体) and GLI (显示 GLI1 抗体), that could be key molecules in the mechanism of SLPI-induced cell migration

  5. we show that SLPI acts as a key mediator in regulating the function of hepatic myeloid cells, to promote resolution responses through induction of MerTK (显示 MERTK 抗体) expression within the resident macrophage population.

  6. these data demonstrate increased anti-inflammatory activity of the SLPI-A16G protein compared with SLPI-WT in a murine model of pulmonary Pseudomonas infection

  7. we demonstrated that the oncogenic effect of SLPI may be due to protection of growth factor progranulin (显示 GRN 抗体) from enzymatic cleavage or suppression of castration-resistant prostate cancer (CRPC)cell apoptosis independent of anti-protease activity of SLPI. These findings implicate SLPI as a potential biomarker of resistance to AR inhibition and therapeutic target for CRPC treatment

  8. Secretory leukocyte protease inhibitor mediates invasiveness of oral carcinoma cells.

  9. The results indicate that SERPINE2 (显示 SERPINE2 抗体) and SLPI play a significant role in the development of papillary thyroid cancer and imply that the evaluation of serum concentrations of both anticoagulant molecules may be considered as additional marker for the differentiation of malignancies during the preoperative diagnosis of patients with thyroid gland tumors.

  10. Bronchial epithelial cells have decreased SLPI expression in response to hypoxia.

Mouse (Murine) Secretory Leukocyte Peptidase Inhibitor (SLPI) interaction partners

  1. We demonstrate by silencing the SLPI gene, that SLPI negatively regulates human periodontal ligament cell expression of the pro-inflammatory cytokines IL-6 (显示 IL6 抗体) and MCP-1 (显示 CPT1B 抗体).

  2. MIF-2 (显示 HSPA5 抗体)/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI- and ATF4 (显示 ATF4 抗体)-dependent mechanisms.

  3. Slpi(-/-) mice had impaired collagen gene expression but animals demonstrated minimal reduction in lung fibrosis compared with wild-type animals. These data suggest that enhanced proteolysis does not further enhance TGF-beta (显示 TGFB1 抗体) activation, and inhibits sustained Col1alpha1, Col3alpha1, and Col4alpha1 gene expression following lung injury.

  4. Data show that differentiative switches between bronchiolar progenitors and club cells are under the Nrf2 (显示 NFE2L2 抗体)-mediated control of SLPI and syndecan 4 (显示 SDC4 抗体).

  5. study identifies a distinct immune response in SA characterized by a dysregulated IFN-gamma (显示 IFNG 抗体)/SLPI axis that affects lung function.

  6. Studied the function of Secretory Leukocyte Protease Inhibitor (SLPI) in odontoblast during mouse tooth development.

  7. Data show that the expression of several genes encoding salivary antimicrobial proteins, such as secretory leukocyte peptidase inhibitor (SLPI), S100A8 (显示 S100A8 抗体), and lactotransferrin (显示 LTF 抗体), was reduced due to myeloid differentiation dactor 88 (MyD88 (显示 MYD88 抗体)) deficiency.

  8. a possible role for SLPI in enhancing the metastatic behavior of breast cancer cell line 4T1

  9. These studies define an important role for SLPI in innate and adaptive immunity and offer new insight into strategies for the use of this naturally occurring molecule in the modulation of infectious and inflammatory diseases.

  10. In experimental autoimmune encephalomyelitis, SLPI exerts potent pro-inflammatory actions by modulation of T-cell activity

SLPI 抗原简介

蛋白简介

This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes\; the protein is also thought to have broad-spectrum anti-biotic activity.

Gene names and symbols associated with SLPI

  • secretory leukocyte peptidase inhibitor (SLPI) 抗体
  • secretory leukocyte peptidase inhibitor (Slpi) 抗体
  • ALK1 抗体
  • ALP 抗体
  • BLPI 抗体
  • ckpi 抗体
  • HUSI 抗体
  • HUSI-I 抗体
  • MATN4 抗体
  • MPI 抗体
  • SLPI 抗体
  • WAP4 抗体
  • WFDC4 抗体

Protein level used designations for SLPI

HUSI-1 , WAP four-disulfide core domain protein 4 , antileukoproteinase , mucus proteinase inhibitor , protease inhibitor WAP4 , secretory leukocyte protease inhibitor (antileukoproteinase) , seminal proteinase inhibitor , ALP , secretory leukocyte protease inhibitor , matrilin 4 , secretory leukocyte peptidase inhibitor

GENE ID SPECIES
6590 Homo sapiens
20568 Mus musculus
84386 Rattus norvegicus
396886 Sus scrofa
504598 Bos taurus
641306 Ovis aries
711156 Macaca mulatta
740668 Pan troglodytes
100127207 Canis lupus familiaris
100137514 Papio anubis
100137521 Pongo abelii
100722975 Cavia porcellus
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