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SLPI encodes a secreted inhibitor which protects epithelial tissues from serine proteases. 再加上，我们可以发SLPI 试剂盒 (52) 和 SLPI 蛋白 (18)和数多这个蛋白质的别的产品。
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Human Monoclonal SLPI Primary Antibody for FACS, IP - ABIN2191907
Wingens, van Bergen, Hiemstra, Meis, van Vlijmen-Willems, Zeeuwen, Mulder, Kramps, van Ruissen, Schalkwijk: Induction of SLPI (ALP/HUSI-I) in epidermal keratinocytes. in The Journal of investigative dermatology 1999
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Human Monoclonal SLPI Primary Antibody for FACS, IP - ABIN2191906
Nakao, Hanada, Asano, Hara, Abdus Salam, Matin, Shimazu, Nakasone, Horibata, Aoba, Honda, Amagasa, Senpuku: Assessment of oral transmission using cell-free human immunodeficiency virus-1 in mice reconstituted with human peripheral blood leucocyte. in Immunology 2003
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Mouse (Murine) Polyclonal SLPI Primary Antibody for ELISA, WB - ABIN1003159
Abe, Kobayashi, Yoshimura, Trapnell, Kim, Hubbard, Brewer, Thompson, Crystal: Expression of the secretory leukoprotease inhibitor gene in epithelial cells. in The Journal of clinical investigation 1991
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Human Polyclonal SLPI Primary Antibody for IHC, ELISA - ABIN1003158
Jana, Gray, Shugars: Human immunodeficiency virus type 1 stimulates the expression and production of secretory leukocyte protease inhibitor (SLPI) in oral epithelial cells: a role for SLPI in innate mucosal immunity. in Journal of virology 2005
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we investigated the biological effects of SLPI using Cell Counting Kit (CCK)-8 (显示 CCK 抗体), Annexin V (显示 ANXA5 抗体)/PI apoptosis assay and Caspase (显示 CASP3 抗体)-Glo(R) 3/7 assay. The findings revealed that SLPI promoted apoptosis in the Leuk1 and WSU-HN4 cell lines. Mechanistic studies indicated that SLPI, at least in part, regulated cell apoptosis by inhibiting the expression of TNF receptor-associated factor 1 (显示 TRAF1 抗体)
Together, these data support the clinical evaluation of dual angiogenic inhibition of the ALK1 (显示 ACVRL1 抗体) and VEGF (显示 VEGFA 抗体) pathways in patients with advanced renal cell carcinoma (显示 MOK 抗体) (RCC (显示 XRCC1 抗体)) .
the patients with systemic sclerosis had significantly increased serum levels of SLPI in comparison with the rheumatoid arthritis patients and the healthy controls
gene expression profiling study based on microarray data for the three cell types identified a number of candidates, including LCP1 (显示 LCP1 抗体) and GLI (显示 GLI1 抗体), that could be key molecules in the mechanism of SLPI-induced cell migration
we show that SLPI acts as a key mediator in regulating the function of hepatic myeloid cells, to promote resolution responses through induction of MerTK (显示 MERTK 抗体) expression within the resident macrophage population.
these data demonstrate increased anti-inflammatory activity of the SLPI-A16G protein compared with SLPI-WT in a murine model of pulmonary Pseudomonas infection
we demonstrated that the oncogenic effect of SLPI may be due to protection of growth factor progranulin (显示 GRN 抗体) from enzymatic cleavage or suppression of castration-resistant prostate cancer (CRPC)cell apoptosis independent of anti-protease activity of SLPI. These findings implicate SLPI as a potential biomarker of resistance to AR inhibition and therapeutic target for CRPC treatment
Secretory leukocyte protease inhibitor mediates invasiveness of oral carcinoma cells.
The results indicate that SERPINE2 (显示 SERPINE2 抗体) and SLPI play a significant role in the development of papillary thyroid cancer and imply that the evaluation of serum concentrations of both anticoagulant molecules may be considered as additional marker for the differentiation of malignancies during the preoperative diagnosis of patients with thyroid gland tumors.
Bronchial epithelial cells have decreased SLPI expression in response to hypoxia.
We demonstrate by silencing the SLPI gene, that SLPI negatively regulates human periodontal ligament cell expression of the pro-inflammatory cytokines IL-6 (显示 IL6 抗体) and MCP-1 (显示 CPT1B 抗体).
MIF-2 (显示 HSPA5 抗体)/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI- and ATF4 (显示 ATF4 抗体)-dependent mechanisms.
Slpi(-/-) mice had impaired collagen gene expression but animals demonstrated minimal reduction in lung fibrosis compared with wild-type animals. These data suggest that enhanced proteolysis does not further enhance TGF-beta (显示 TGFB1 抗体) activation, and inhibits sustained Col1alpha1, Col3alpha1, and Col4alpha1 gene expression following lung injury.
Data show that differentiative switches between bronchiolar progenitors and club cells are under the Nrf2 (显示 NFE2L2 抗体)-mediated control of SLPI and syndecan 4 (显示 SDC4 抗体).
study identifies a distinct immune response in SA characterized by a dysregulated IFN-gamma (显示 IFNG 抗体)/SLPI axis that affects lung function.
Studied the function of Secretory Leukocyte Protease Inhibitor (SLPI) in odontoblast during mouse tooth development.
Data show that the expression of several genes encoding salivary antimicrobial proteins, such as secretory leukocyte peptidase inhibitor (SLPI), S100A8 (显示 S100A8 抗体), and lactotransferrin (显示 LTF 抗体), was reduced due to myeloid differentiation dactor 88 (MyD88 (显示 MYD88 抗体)) deficiency.
a possible role for SLPI in enhancing the metastatic behavior of breast cancer cell line 4T1
These studies define an important role for SLPI in innate and adaptive immunity and offer new insight into strategies for the use of this naturally occurring molecule in the modulation of infectious and inflammatory diseases.
In experimental autoimmune encephalomyelitis, SLPI exerts potent pro-inflammatory actions by modulation of T-cell activity
This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes\; the protein is also thought to have broad-spectrum anti-biotic activity.
, WAP four-disulfide core domain protein 4
, mucus proteinase inhibitor
, protease inhibitor WAP4
, secretory leukocyte protease inhibitor (antileukoproteinase)
, seminal proteinase inhibitor
, secretory leukocyte protease inhibitor
, matrilin 4
, secretory leukocyte peptidase inhibitor