This intronless gene encodes a member of the SLITRK protein family. These proteins are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. The protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome.[provided by RefSeq, Mar 2010].
Fabbrini, Pasquini, Aurilia, Berardelli, Breedveld, Oostra, Bonifati, Berardelli: "A large Italian family with Gilles de la Tourette syndrome: clinical study and analysis of the SLITRK1 gene." in: Movement disorders : official journal of the Movement Disorder Society, Vol. 22, Issue 15, pp. 2229-34, (2007) (PubMed).
Abelson, Kwan, ORoak, Baek, Stillman, Morgan, Mathews, Pauls, Rasin, Gunel, Davis, Ercan-Sencicek, Guez, Spertus, Leckman, Dure, Kurlan, Singer, Gilbert, Farhi, Louvi, Lifton, Sestan, State: "Sequence variants in SLITRK1 are associated with Tourette's syndrome." in: Science (New York, N.Y.), Vol. 310, Issue 5746, pp. 317-20, (2005) (PubMed).
Aruga, Mikoshiba: "Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth." in: Molecular and cellular neurosciences, Vol. 24, Issue 1, pp. 117-29, (2003) (PubMed).
Aruga, Yokota, Mikoshiba: "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue." in: Gene, Vol. 315, pp. 87-94, (2003) (PubMed).
Aliases for SLITRK1 抗体
SLIT and NTRK like family member 1 (SLITRK1) 抗体 SLIT and NTRK like family member 1 (slitrk1) 抗体 SLIT and NTRK-like family, member 1 (Slitrk1) 抗体 3200001I04Rik 抗体 DKFZp459G0529 抗体 LRRC12 抗体 TTM 抗体