This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008].
Wilhelm, Kukekov, Schmit, Biagas, Sproul, Gire, Maes, Xu, Greene: "Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein." in: The Journal of biological chemistry, Vol. 287, Issue 3, pp. 2247-56, (2012) (PubMed).
Wilhelm, Xu, Kukekov, Gire, Greene: "Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model." in: The Journal of biological chemistry, Vol. 282, Issue 2, pp. 1288-95, (2007) (PubMed).