anti-Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) 抗体

Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. 再加上,我们可以发ROBO4 试剂盒 (12)ROBO4 蛋白 (8)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
ROBO4 54538 Q8WZ75
ROBO4 74144 Q8C310
ROBO4 300518 Q80W87
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antibodies-online.cn销售最多的anti-ROBO4 抗体

Showing 10 out of 87 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
非结合性 WB 100 μg 2至3个工作日
非结合性 IF (p), IHC (p), WB Mouse intestine cells probed with Rabbit Anti-Robo4 Polyclonal Antibody, FITC Conjugated (ABIN714866-FITC) (green) at 1:50 for 60 minutes compared to control cells (red). Rat brain lysate probed with Anti Robo4 Polyclonal Antibody, Unconjugated  at 1:3000 for 90 min at 37˚C. Predicted band 108kD. Observed band size: 171kD 100 μL 3至7个工作日
非结合性 IHC (p), WB 100 μL 6至7个工作日
非结合性 ELISA   100 μL 14至16个工作日
Alexa Fluor 594 IF (p)   100 μL 14至21个工作日
非结合性 ICC, IF, IHC (p), WB 100 μL 6至7个工作日
Alexa Fluor 350 IF (p)   100 μL 14至21个工作日
Alexa Fluor 647 IF (p)   100 μL 14至21个工作日
Alexa Fluor 555 IF (p)   100 μL 14至21个工作日
Alexa Fluor 488 IF (p)   100 μL 14至21个工作日

引用最多的anti-ROBO4 抗体

  1. Human Polyclonal ROBO4 Primary Antibody for FACS, WB - ABIN4900077 : Zhang, Prahst, Mathivet, Pibouin-Fragner, Zhang, Genet, Tong, Dubrac, Eichmann: The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization. in Nature communications 2016 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal ROBO4 Primary Antibody for CyTOF, FACS - ABIN4900078 : Guijarro-Muñoz, Cuesta, Alvarez-Cienfuegos, Geng, Alvarez-Vallina, Sanz: The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis. in Experimental cell research 2012 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal ROBO4 Primary Antibody for FACS - ABIN4897148 : Zhang, Fisher, Newey, Smythe, Tatton, Tsaknakis, Forde, Carpenter, Athanassopoulos, Hale, Ferguson, Tyler, Watt: The impact of proliferative potential of umbilical cord-derived endothelial progenitor cells and hypoxia on vascular tubule formation in vitro. in Stem cells and development 2009 (PubMed)

  4. Human Polyclonal ROBO4 Primary Antibody for CyTOF, FACS - ABIN4900080 : Pircher, Schäfer, Eigentler, Pichler, Puhr, Steiner, Horninger, Gunsilius, Klocker, Heidegger: Robo 4 - the double-edged sword in prostate cancer: impact on cancer cell aggressiveness and tumor vasculature. in International journal of medical sciences 2019 (PubMed)


Human Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) interaction partners

  1. Targeted sequencing of ROBO4 showed enrichment for rare variants in BAV/AscAA probands compared with controls.

  2. Robo 4 is a tumor endothelial marker expressed in the vascular network of various tumor entities.

  3. Low expression level of ROBO4 is associated with evasive resistance and disease progression in cancer.

  4. GM-CSF and IL-1beta. Taken together, we demonstrated novel Robo4 functions in inflammation, i.e., it promotes IL-6 production by endothelial cells and immune cells via crosstalk.

  5. Results show that hyperglycemia-induced upregulation of Robo4 in retinal endothelial cells is directly mediated by transcription factor SP1 which increases the transcription of Robo4 via an additional binding site in Robo4 promoter. SP1/Robo4 can regulate the migration, monolayer permeability and angiogenesis of retinal endothelial cells under hyperglycemic conditions.

  6. Overexpression of Roundabout4 is associated with glioma.

  7. there was a increase in Robo4 expression under hyperglycemic conditions, while there was a decrease under hypoxic and combined hypoxic and hyperglycemic conditions, suggesting Robo4 might play different roles in various stages of diabetic retinopathy

  8. These results suggest that Slit2/Robo1 binding exerts an effect on cell migration, which is negatively regulated by Robo4, and Robo1 may function by interacting with CdGAP in HUVECs.

  9. results indicate that AP-1 complexes regulate Robo4 gene expression in endothelial cells

  10. BM Robo4 expression can serve as a new biomarker to predict clinical outcomes in AML patients and Robo4 may serve as a potential therapeutic target in patients with higher Robo4 expression.

  11. Robo4 suppressed glioma-induced endothelial cell proliferation, migration and tube formation in vitro by inhibiting VEGR2-mediated activation of PI3K/AKT and FAK signaling pathways.

  12. Increased or decreased expression of Robo4 by stimulation or knockdown of HIF-1alpha suggesting that Robo4 is positively regulated by HIF-1alpha under normoxic and hypoxic conditions in microvascular endothelial cells in vitro.

  13. Plasma Robo4 levels are increased, transiently, following cardiac surgery requiring CPB

  14. This study demonistrated that roundabout 4 regulates blood-tumor barrier permeability through the modulation of ZO-1, Occludin, and Claudin-5 expression.

  15. Endothelial cell-specific DNA methylation pattern of the Robo4 proximal promoter is determined during cell differentiation and contributes to regulation of EC-specific Robo4 gene expression.

  16. SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo.

  17. Slit2-Robo4 is a key regulator of endothelial inflammation, and its dysregulation during endotoxemia is a novel mechanism for LPS-induced vascular pathogenesis.

  18. Here I will discuss the regulation mechanism of Robo4 gene expression by transcription factors and epigenetic control. [Review]

  19. SiRNA knockdown of Robo4 in pulmonary microvascular endothelial cells prevented Slit2 inhibition of Andes virus induced permeability demonstrating that Robo4 receptors determine pulmonary microvascular endothelial cells responsiveness to Slit2

  20. targeting Slit2/Robo4 signaling may protect the integrity of the lymphatic barrier and limit the dissemination of HIV in the host.

Mouse (Murine) Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) interaction partners

  1. Robo4 inhibits angiogenesis and vessel permeability independently of its cytoplasmic domain. Robo4 deletion enhances permeability and revascularization in oxygen-induced retinopathy (OIR) and accelerates cutaneous wound healing.

  2. endothelial Robo4 signaling is important for suppressing breast cancer growth and metastasis, and it can be targeted (enhanced) by administrating a small molecular drug.

  3. Robo4 vaccines induce antibodies that retard tumor growth.

  4. Robo4 and Src family kinases are involved in the mechanisms of embryonic vascular defects caused by the Hrt/Hey deficiency.

  5. These results clearly indicate that Robo4 plays a role in hematopoietic stem cells trafficking such as bone marrow homing and peripheral mobilization.

  6. our results showed an important role of Robo4 in the regulation of cortical radial migration through Slit-dependent and -independent mechanisms

  7. Data found that expression of Slit2 and SDF1 were dynamically regulated in mesenchymal stem cells and OBC-like populations following radiation, while Robo4 expression was restricted to endothelial cells.

  8. augmenting the host Robo4/Slit2 system could provide a useful therapeutic approach to control pathological angiogenesis associated with HSV induced stromal keratitis

  9. Robo4 specifically binds to UNC5B, a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors.

  10. Activating with the soluble ligand Slit an endothelium-specific, Robo4-dependent signaling pathway that strengthens the vascular barrier, diminishing deleterious aspects of the host's response to the pathogen-induced cytokine storm.

  11. enhanced growth of blood vessels in Robo4(-/-) endothelium is due to activation of vascular endothelial growth factor (VEGF)-R2 signaling through the Src and FAK kinases.

  12. Robo4 is a bona fide member of the Robo family and may provide a repulsive cue to migrating endothelial cells during vascular development.

  13. Robo4 is expressed in hematopoietic stem cells (HSC), and Robo4/Slit2 signaling may play a role in HSC homeostasis in the bone marrow niche.

  14. Robo4 mRNA level decreases during vascular decline in pulmonary fibrosis.

Zebrafish Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) interaction partners

  1. Sox7 and Sox18-mediated transcriptional regulation of Robo4 is important in the developing embryonic vasculature

  2. robo4 is essential for coordinated symmetric and directed sprouting of intersomitic vessels.

  3. Robo4 mediates attraction-signaling mechanisms through Rho GTPases in vertebrate vascular guidance

ROBO4 抗原简介


Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).

Gene names and symbols associated with ROBO4

  • roundabout guidance receptor 4 (ROBO4) 抗体
  • roundabout guidance receptor 4 (Robo4) 抗体
  • roundabout, axon guidance receptor, homolog 4 (Drosophila) (robo4) 抗体
  • 1200012D01Rik 抗体
  • AI593217 抗体
  • ECSM4 抗体
  • MRB 抗体
  • sc:d0823 抗体
  • wu:fa16f09 抗体

Protein level used designations for ROBO4

roundabout homolog 4 , roundabout homolog 4, magic roundabout , Magic roundabout , magic roundabout

54538 Homo sapiens
74144 Mus musculus
300518 Rattus norvegicus
560765 Danio rerio
489306 Canis lupus familiaris
100524821 Sus scrofa
783785 Bos taurus
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