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Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. 再加上，我们可以发ROBO4 试剂盒 (8) 和 ROBO4 蛋白 (8)和数多这个蛋白质的别的产品。
Showing 10 out of 128 products:
Human Polyclonal ROBO4 Primary Antibody for FACS, WB - ABIN4900077
Zhang, Prahst, Mathivet, Pibouin-Fragner, Zhang, Genet, Tong, Dubrac, Eichmann: The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization. in Nature communications 2016
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Human Monoclonal ROBO4 Primary Antibody for CyTOF, FACS - ABIN4900078
Guijarro-Muñoz, Cuesta, Alvarez-Cienfuegos, Geng, Alvarez-Vallina, Sanz: The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis. in Experimental cell research 2012
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Human Monoclonal ROBO4 Primary Antibody for FACS - ABIN4897148
Zhang, Fisher, Newey, Smythe, Tatton, Tsaknakis, Forde, Carpenter, Athanassopoulos, Hale, Ferguson, Tyler, Watt: The impact of proliferative potential of umbilical cord-derived endothelial progenitor cells and hypoxia on vascular tubule formation in vitro. in Stem cells and development 2009
Low expression level of ROBO4 is associated with evasive resistance and disease progression in cancer.
GM-CSF (显示 CSF2 抗体) and IL-1beta (显示 IL1B 抗体). Taken together, we demonstrated novel Robo4 functions in inflammation, i.e., it promotes IL-6 (显示 IL6 抗体) production by endothelial cells and immune cells via crosstalk.
Results show that hyperglycemia-induced upregulation of Robo4 in retinal endothelial cells is directly mediated by transcription factor SP1 (显示 SP1 抗体) which increases the transcription of Robo4 via an additional binding site in Robo4 promoter. SP1 (显示 PSG1 抗体)/Robo4 can regulate the migration, monolayer permeability and angiogenesis of retinal endothelial cells under hyperglycemic conditions.
there was a increase in Robo4 expression under hyperglycemic conditions, while there was a decrease under hypoxic and combined hypoxic and hyperglycemic conditions, suggesting Robo4 might play different roles in various stages of diabetic retinopathy
These results suggest that Slit2 (显示 SLIT3 抗体)/Robo1 (显示 ROBO1 抗体) binding exerts an effect on cell migration, which is negatively regulated by Robo4, and Robo1 (显示 ROBO1 抗体) may function by interacting with CdGAP (显示 ARHGAP31 抗体) in HUVECs.
results indicate that AP-1 (显示 FOSB 抗体) complexes regulate Robo4 gene expression in endothelial cells
BM Robo4 expression can serve as a new biomarker to predict clinical outcomes in AML (显示 RUNX1 抗体) patients and Robo4 may serve as a potential therapeutic target in patients with higher Robo4 expression.
Robo4 suppressed glioma-induced endothelial cell proliferation, migration and tube formation in vitro by inhibiting VEGR2-mediated activation of PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体) and FAK (显示 PTK2 抗体) signaling pathways.
Increased or decreased expression of Robo4 by stimulation or knockdown of HIF-1alpha (显示 HIF1A 抗体) suggesting that Robo4 is positively regulated by HIF-1alpha (显示 HIF1A 抗体) under normoxic and hypoxic conditions in microvascular endothelial cells in vitro.
Plasma Robo4 levels are increased, transiently, following cardiac surgery requiring CPB (显示 CPB1 抗体)
endothelial Robo4 signaling is important for suppressing breast cancer growth and metastasis, and it can be targeted (enhanced) by administrating a small molecular drug.
Robo4 vaccines induce antibodies that retard tumor growth.
Robo4 and Src family kinases are involved in the mechanisms of embryonic vascular defects caused by the Hrt/Hey deficiency.
These results clearly indicate that Robo4 plays a role in hematopoietic stem cells trafficking such as bone marrow homing and peripheral mobilization.
our results showed an important role of Robo4 in the regulation of cortical radial migration through Slit-dependent and -independent mechanisms
Data found that expression of Slit2 (显示 SLIT2 抗体) and SDF1 (显示 CXCL12 抗体) were dynamically regulated in mesenchymal stem cells and OBC-like populations following radiation, while Robo4 expression was restricted to endothelial cells.
augmenting the host Robo4/Slit2 system could provide a useful therapeutic approach to control pathological angiogenesis associated with HSV induced stromal keratitis
Robo4 specifically binds to UNC5B (显示 UNC5B 抗体), a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors.
Activating with the soluble ligand Slit an endothelium-specific, Robo4-dependent signaling pathway that strengthens the vascular barrier, diminishing deleterious aspects of the host's response to the pathogen-induced cytokine storm.
enhanced growth of blood vessels in Robo4(-/-) endothelium is due to activation of vascular endothelial growth factor (VEGF)-R2 signaling through the Src and FAK kinases.
Sox7 (显示 SOX7 抗体) and Sox18 (显示 SOX18 抗体)-mediated transcriptional regulation of Robo4 is important in the developing embryonic vasculature
robo4 is essential for coordinated symmetric and directed sprouting of intersomitic vessels.
Robo4 mediates attraction-signaling mechanisms through Rho GTPases in vertebrate vascular guidance
Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).
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