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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
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Low RPL5 expression is associated with cancer.
Ribosomal proteins L11 (显示 RPL11 蛋白) and L5 activate TAp73 (显示 TP73 蛋白) by overcoming MDM2 (显示 MDM2 蛋白) inhibition.
RPL5 mutation is associated with Diamond Blackfan Anemia.
Findings uncover a mechanism by which RPL5 and RPL11 (显示 RPL11 蛋白) can co-operatively suppress c-Myc (显示 MYC 蛋白) expression, allowing a tightly controlled ribosome biogenesis in cells.
Unlike other tumor suppressors, RPL5 and RPL11 play essential roles in normal cell proliferation.
High frequency of RPL5 gene deletion is associated with Italian Diamond-Blackfan anemia.
Oncogenic splicing factor (显示 SLU7 蛋白) SRSF1 (显示 SRSF1 蛋白) stabilizes the tumor suppressor protein p53 (显示 TP53 蛋白) via RPL5, inducing cell senescence.
Mutations affect the ribosomal proteins RPL5 and RPL10 (显示 RPL10 蛋白) in 12 of 122 (9.8%) pediatric T-cell acute lymphoblastic leukemias.
disrupted nucleoli may provide a platform for L5- and L11 (显示 RPL11 蛋白)-dependent p53 (显示 TP53 蛋白) activation, implying a role for the nucleolus in p53 (显示 TP53 蛋白) activation by ribosomal biogenesis stress
Data show 1 proband with an RPL5 deletion, 1 patient with an RPL35A (显示 RPL35A 蛋白) deletion, 3 with RPS17 (显示 RPS17 蛋白) deletions, and 1 with an RPS19 (显示 RPS19 蛋白) deletion.
there is a fine tuned balance in the interaction of ribosomal proteins with the MDM2 (显示 MDM2 蛋白)/p53 (显示 TP53 蛋白) axis which is important in normal hematopoiesis.
There was a significant delay in the G2/M phase in Rpl5 mutant cells, unaffected by p53 (显示 TP53 蛋白) knockdown.
RpL5, located in the centric heterochromatin of chromosome 2, was analyzed genetically.
eclipse might be a novel ribosome associated protein interacting with dRPL5
These results therefore provide a comprehensive basis for the study of molecular pathogenesis of RPL5-mediated Diamond-Blackfan anemia and other ribosomopathies.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18P family of ribosomal proteins. It is located in the cytoplasm. The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The protein interacts specifically with the beta subunit of casein kinase II. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
60S ribosomal protein L5
, enhancer on chromosome 2, complementation group d
, ribosomal protein L5
, yippee interacting protein 6
, 60S ribosomal protein L5-B
, 60S ribosomal protein L5-like protein
, ribosomal protein L5, like