Ribosomal Protein L5 蛋白 (RPL5)

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.

列出全部蛋白 基因 基因ID UniProt
大鼠 RPL5 RPL5 81763 P09895
人 RPL5 RPL5 6125 P46777
小鼠 RPL5 RPL5 100503670 P47962
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大肠杆菌（E. Coli） 人 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
$4,744.22
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大肠杆菌（E. Coli） 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
$4,744.22
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大肠杆菌（E. Coli） 人 GST tag Ribosomal Protein L5 (RPL5) (AA 2-297), (full length) protein (GST tag) 1 mg Log in to see 60至71个工作日
$1,842.50
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小麦胚 人 GST tag 10 μg Log in to see 11至12个工作日
$414.29
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酵母菌 兔 His tag   1 mg Log in to see 60至71个工作日
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酵母菌 REACT_Eggplant His tag   1 mg Log in to see 60至71个工作日
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酵母菌 野猪 His tag   1 mg Log in to see 60至71个工作日
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酵母菌 Acanthamoeba castellanii His tag   1 mg Log in to see 60至71个工作日
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酵母菌 Cyanophora paradoxa His tag   1 mg Log in to see 60至71个工作日
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酵母菌 Reclinomonas americana His tag   1 mg Log in to see 60至71个工作日
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更多Ribosomal Protein L5 (RPL5)互动伙伴

Human Ribosomal Protein L5 (RPL5) interaction partners

  1. Low RPL5 expression is associated with cancer.

  2. Ribosomal proteins L11 (显示 RPL11 蛋白) and L5 activate TAp73 (显示 TP73 蛋白) by overcoming MDM2 (显示 MDM2 蛋白) inhibition.

  3. RPL5 mutation is associated with Diamond Blackfan Anemia.

  4. Findings uncover a mechanism by which RPL5 and RPL11 (显示 RPL11 蛋白) can co-operatively suppress c-Myc (显示 MYC 蛋白) expression, allowing a tightly controlled ribosome biogenesis in cells.

  5. Unlike other tumor suppressors, RPL5 and RPL11 play essential roles in normal cell proliferation.

  6. High frequency of RPL5 gene deletion is associated with Italian Diamond-Blackfan anemia.

  7. Oncogenic splicing factor (显示 SLU7 蛋白) SRSF1 (显示 SRSF1 蛋白) stabilizes the tumor suppressor protein p53 (显示 TP53 蛋白) via RPL5, inducing cell senescence.

  8. Mutations affect the ribosomal proteins RPL5 and RPL10 (显示 RPL10 蛋白) in 12 of 122 (9.8%) pediatric T-cell acute lymphoblastic leukemias.

  9. disrupted nucleoli may provide a platform for L5- and L11 (显示 RPL11 蛋白)-dependent p53 (显示 TP53 蛋白) activation, implying a role for the nucleolus in p53 (显示 TP53 蛋白) activation by ribosomal biogenesis stress

  10. Data show 1 proband with an RPL5 deletion, 1 patient with an RPL35A (显示 RPL35A 蛋白) deletion, 3 with RPS17 (显示 RPS17 蛋白) deletions, and 1 with an RPS19 (显示 RPS19 蛋白) deletion.

Mouse (Murine) Ribosomal Protein L5 (RPL5) interaction partners

  1. there is a fine tuned balance in the interaction of ribosomal proteins with the MDM2 (显示 MDM2 蛋白)/p53 (显示 TP53 蛋白) axis which is important in normal hematopoiesis.

  2. Ribosomal proteins L11 (显示 RPL11 蛋白) and L5 activate TAp73 (显示 TP73 蛋白) by overcoming MDM2 (显示 MDM2 蛋白) inhibition.

  3. There was a significant delay in the G2/M phase in Rpl5 mutant cells, unaffected by p53 (显示 TP53 蛋白) knockdown.

Fruit Fly (Drosophila melanogaster) Ribosomal Protein L5 (RPL5) interaction partners

  1. RpL5, located in the centric heterochromatin of chromosome 2, was analyzed genetically.

  2. eclipse might be a novel ribosome associated protein interacting with dRPL5

Zebrafish Ribosomal Protein L5 (RPL5) interaction partners

  1. These results therefore provide a comprehensive basis for the study of molecular pathogenesis of RPL5-mediated Diamond-Blackfan anemia and other ribosomopathies.

蛋白简介RPL5

蛋白简介

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18P family of ribosomal proteins. It is located in the cytoplasm. The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The protein interacts specifically with the beta subunit of casein kinase II. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Gene names and symbols associated with Ribosomal Protein L5 蛋白 (RPL5)

  • ribosomal protein L5 (Rpl5)
  • ribosomal protein L5 (RPL5)
  • 60S ribosomal protein L5 (rpl-5)
  • Ribosomal protein L5 (RpL5)
  • ribosomal protein L5 L homeolog (rpl5.L)
  • 50S ribosomal protein L5 (rpl5)
  • ribosomal protein L5 (rpl5)
  • ribosomal protein L5 (RpL5)
  • ribosomal protein L5b (rpl5b)
  • rpl5 (rpl5)
  • ribosomal protein L5a (rpl5a)
  • CG17489 蛋白
  • DBA6 蛋白
  • Dmel\\CG17489 蛋白
  • dRPL5 蛋白
  • E-2d 蛋白
  • L5 蛋白
  • M(2)40B 蛋白
  • mg:cb01f08 蛋白
  • rpl5 蛋白
  • Rp L5 蛋白
  • rpl5l 蛋白
  • U21RNA 蛋白
  • wu:fj02g05 蛋白
  • yip6 蛋白
  • zgc:56511 蛋白
  • zgc:77176 蛋白
  • zgc:86854 蛋白

Protein level used designations for Ribosomal Protein L5 蛋白 (RPL5)

60S ribosomal protein L5 , CG17489-PA , CG17489-PB , CG17489-PF , CG17489-PG , RpL5-PA , RpL5-PB , RpL5-PF , RpL5-PG , enhancer on chromosome 2, complementation group d , ribosomal protein L5 , yippee interacting protein 6 , 60S ribosomal protein L5-B , 60S ribosomal protein L5-like protein , fj02g05 , ribosomal protein L5, like

GENE ID SPECIES
81763 Rattus norvegicus
395269 Gallus gallus
6125 Homo sapiens
100135671 Sus scrofa
515238 Bos taurus
100008649 Oryctolagus cuniculus
100503670 Mus musculus
174371 Caenorhabditis elegans
3355124 Drosophila melanogaster
379124 Xenopus laevis
479949 Canis lupus familiaris
100033985 Equus caballus
801524 Cyanophora paradoxa
801146 Reclinomonas americana
1734048 Acanthamoeba castellanii
692557 Bombyx mori
415196 Danio rerio
2702471 Marchantia polymorpha
326961 Danio rerio
100717151 Cavia porcellus
101104192 Ovis aries musimon
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