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RPN2 encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. 再加上，我们可以发Ribophorin II 抗体 (59) 和 Ribophorin II 蛋白 (11)和数多这个蛋白质的别的产品。
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Rpn13-Rpn2 complex structural analysis shows that RA190 targets hRpn13 and Uch37 through parallel mechanisms and at proteasomes, RA190-inactivated Uch37 cannot disassemble hRpn13-bound ubiquitin chains
These findings indicated a novel pathway of tumor-promoting activity by RPN2 in colorectal cancer (CRC), with significant implications for unraveling the tumorigenesis of CRC.
RPN2 expression correlates with gastric adenocarcinoma cell invasion and shows promise as a new prognostic factor in human gastric adenocarcinoma
Data suggest that RPN2 is involved in the regulation of lethal cancer phenotypes and represents a promising new target for RNAi-based medicine against non-small cell lung cancer.
Of the total, the deregulation of several genes (CDK1, CDK2, CDK4, MCM2, MCM3, MCM4, EIF3a and RPN2) were potentially associated with disease development and progression.
these results indicated that high glycosylation of CD63 by RPN2 is implicated in clinical outcomes in breast cancer patients
Furthermore, our study reveals that high expression of RPN2 and concomitant accumulation of mtp53 were associated with cancer tissues in a small cohort of metastatic breast cancer patients.
Rpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain interactions, thus activating hRpn13 for ubiquitin binding.
RPN2 gene confers docetaxel resistance in breast cancer.
S-glutathionylation of Rpn2 is a contributory mechanism for H2O2-induced inhibition of 26 S proteasomal function
Data show that the decay of metabolically labeled p53 follows biphasic kinetics, while 20 S proteasome executes the first phase by default, and the second phase requires the 26 S proteasome.
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit
, dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
, oligosaccharyltransferase complex subunit (non-catalytic)
, ribophorin 2
, ribophorin II
, ribophorin ii
, dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like
, ribophorin II S homeolog