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we observed frameshift mutations of RARRES3 in 11 cases of colorectal cancer
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Identified the tumor suppressor RARRES3 as a critical target of G9a. Epigenetic silencing of RARRES3 contributed to the tumor-promoting function of G9a
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this study indicated that increased expression of TIG3 in primary glioblastoma is a novel biomarker for predicting poor outcome of patients. We then hypothesize that TIG3 may function in a different pattern in glioblastoma
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Overexpression of TIG3 suppresses tumor growth in hepatocellular carcinoma
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Letter: Interleukin-22 inhibits tazarotene-induced gene 3 expression in keratinocytes via MAPK-ERK1/2 and JAK2/STAT3 signaling.
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findings provide a new insight into the molecular link between p53, protein acylation and Wnt/beta-catenin signaling whereby RARRES3 plays a pivotal role in modulating the acylation status of signaling proteins.
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the flexible main loop of H-REV107, but not that of TIG3, is critical for its NTD to modulate its CTD in inducing cell death.
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RARRES3 downregulation engages metastasis-initiating capabilities by facilitating adhesion of the tumor cells to the lung parenchyma.
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These findings argue that TIG3 is involved in the control of keratinocyte differentiation and that loss of TIG3 in transformed cells contributes to the malignant phenotype.
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We show that the C-terminal hydrophobic domain targets intact TIG3 to the plasma membrane, but when isolated as an independent element localizes at the mitochondria and a segment of the N-terminal hydrophilic region targets the centrosome.
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Low RIG1 expression is associated with testis cancer.
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RIG1 gene is a downstream target of p53 in cancer cell lines
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Data suggest that pericentrosomal localization of TIG3 is a key event that results in microtubule and microfilament redistribution and pericentrosomal organelle clustering and that leads to cancer cell apoptosis.
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We conclude that TG1-catalysed cross-linking, regulated by TIG3, might play an important role in the formation of neuronal tau inclusions in certain tauopathies
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induction of TIG3 is associated with the suppression of anchorage-independent growth in certain aerodigestive tract cancer cells
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TIG3 facilitates the terminal stages in keratinocyte differentiation via activation of type I transglutaminase
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altered RARRES3 expression may play a role in the carcinogenesis of the liver and biliary tract.
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identification and characterization of the functional RA response element that is responsible for the RA-mediated induction of RIG1 gene
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TIG3 is negatively regulated by an activated MEK-ERK signaling pathway in ovarian carcinoma.
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The proapoptotic and anti-RAS activities of RIG1 are primarily associated with the Golgi localization of the protein.
