anti-Regulator of Telomere Elongation Helicase 1 (RTEL1) 抗体

In mice, inactivation of the Rtel (regulator of telomere length) gene has been shown to cause chromosome breaks, fusions, and telomere loss. 再加上,我们可以发和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
RTEL1 51750 Q9NZ71
RTEL1 269400 Q0VGM9
RTEL1 362288 Q5RJZ1
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Showing 10 out of 44 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 ICC, IF, IHC, IHC (p), IP, WB Western Blot: RTEL1 Antibody [NBP2-22360] - WB analysis of RTEL1 in HeLa cell lysate. Immunocytochemistry/Immunofluorescence: RTEL1 Antibody [NBP2-22360] - RTEL1 antibody was tested in Hela cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mL Log in to see 7至9个工作日
非结合性 ELISA, IHC, IHC (p), WB Human Small Intestine (formalin-fixed, paraffin-embedded) stained with RTEL1 antibody ABIN334244 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-RTEL1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11至14个工作日
非结合性 ELISA, IHC (p), WB Immunohistochemistry-Paraffin: RTEL1 Antibody [NBP1-40056] - Analysis of anti-RTEL1 antibody with human small intestine at concentration 5 ug/ml. 0.05 mg Log in to see 10至13个工作日
非结合性 EIA, IHC (p), WB   50 μg Log in to see 2至3个工作日
非结合性 IHC (p), ELISA, WB 50 μg Log in to see 12至14个工作日
非结合性 ICC, IF Immunocytochemistry/Immunofluorescence: RTEL1 Antibody  - Staining of human cell line PC-3 shows localization to nuclear speckles & nuclear membrane. 100 μL Log in to see 10至13个工作日
非结合性 ELISA, WB Western blot analysis of RTEL1 using anti-RTEL1 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat testis tissue lysates, Lane 2: rat PC-12 whole cell lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-RTEL1 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for RTEL1 at approximately 134KD. The expected band size for RTEL1 is at 134KD. 100 μg Log in to see 4至6个工作日
非结合性 ELISA, WB   100 μg Log in to see 11至14个工作日
非结合性 IHC, ELISA, WB 0.05 mg Log in to see 2至3个工作日
非结合性 WB   100 μL Log in to see 2至3个工作日

引用最多的anti-RTEL1 抗体

  1. Human Polyclonal RTEL1 Primary Antibody for ICC, IF - ABIN4351321 : Chan, Fugger, West: Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations. in Nature cell biology 2018 (PubMed)


Arabidopsis thaliana Regulator of Telomere Elongation Helicase 1 (RTEL1) interaction partners

  1. The RTEL1 homolog in Arabidopsis thaliana plays multiple roles in preserving genome stability.

Human Regulator of Telomere Elongation Helicase 1 (RTEL1) interaction partners

  1. Study demonstrates that previously identified loci in RTEL1 are confirmed to have an association with increased risk of adult gliomas. Moreover, two coding variants (rs6062302 and rs115303435) were found to confer independent risk for glioma in RTEL1. A novel missense SNP (rs77086616, T434M) was also observed only in Korean glioma samples.

  2. RTEL1 SNPs were associated with relative telomere length. Shorter relative telomere length was associated with an increased risk of stroke.

  3. heterozygous RTEL1 variants were associated with marrow failure, and telomere length measurement alone may not identify patients with telomere dysfunction carrying RTEL1 variants.

  4. Observation are firstly, heterozygous LOF RTEL1 variants are associated with myelodysplasia and liver disease in adulthood. Secondly, biallelic RTEL1 variants can present with just bone marrow failure in adulthood. Thirdly, many heterozygous variants, and even some biallelic RTEL1 variants, are bystanders.

  5. a novel association signal in the RTEL1 gene (intronic single nucleotide poly morphism (SNP) rs2297439; P=2.82x10(-7)) that is independent of previously reported Telomere-associated SNPs in this region.

  6. Findings suggest a potential association between regulator of telomere elongation helicase 1 (RTEL1) polymorphisms and lung cancer (LC) risk in a Chinese Han population.

  7. Pulmonary fibrosis patients with mutations in telomerase reverse transcriptase, telomerase RNA component, regulator of telomere elongation helicase 1 and poly(A)-specific ribonuclease were identified and clinical data were analysed. Genetic mutations in telomere related genes lead to a variety of interstitial lung disease diagnoses that are universally progressive.

  8. promoter methylated in 51.4% of lung cancer patients and in 8.8% of healthy individuals

  9. The allele "G" of rs6089953 and rs6010621 and the allele "A" of rs2297441 were associated with decreased risk of High altitude pulmonary edema, haplotype "GG, GT, AT" of rs6089953-rs6010621 were detected significantly associated with High altitude pulmonary edema risk in the Chinese population.

  10. SNPs in the RTEL1 are associated with COPD in a Chinese Han population. It is possible that these variants are COPD risk factors.

  11. This meta-analysis demonstrates that the RTEL1 rs2297440 polymorphism plays a moderate, but significant role in the risk of glioma.

  12. Genetic risk variants in the RTEL1 gene is associated with somatic biomarkers in glioma.

  13. Deletion in the RTEL1 gene is associated with metastatic glioblastoma.

  14. Telomere length is associated with Esophageal squamous cell carcinoma risk in a U-shaped pattern and demonstrates that TL-SNPs may not be important in carcinogenesis in Chinese population.

  15. Heterozygous RTEL1 mutations are responsible for familial pulmonary fibrosis (FPF) and, thereby, extend the clinical spectrum of RTEL1 deficiency. Thus, RTEL1 enlarges the number of telomere-associated genes implicated in FPF.

  16. results suggest a significant association between the RETL1, TREH, and PHLDB1 genes and GBM development in the Han Chinese population

  17. A homozygous mutation of RTEL1 in a child presenting with an apparently isolated natural killer cell deficiency.

  18. RTEL1 single nucleotide polymorphisms are associated with decreased susceptibility to pediatric brain astrocytoma.

  19. Association between the RTEL1 rs6010620 polymorphism and glioma risk was significant. [Meta-Analysis]

  20. PARN and RTEL1 mutation carriers had shortened leukocyte telomere lengths.

Mouse (Murine) Regulator of Telomere Elongation Helicase 1 (RTEL1) interaction partners

  1. Rtel1 binds to and inhibits restart of reversed replication forks within telomeres, which compromises replication and leads to critically short telomeres.

  2. RTEL1 plays a critical role in both telomere and genome-wide replication, which is crucial for genetic stability and tumor avoidance.

  3. Upregulated RTEL1 is tumorigenic and is able to initiate the formation of hepatocellular carcinoma in mice.

  4. propose that mRtel1 is a key protein for DNA replication, recombination, and repair and efficient elongation of telomeres by telomerase

  5. RTEL1 performs two distinct functions at telomeres: it disassembles T loops and also counteracts telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.

Cow (Bovine) Regulator of Telomere Elongation Helicase 1 (RTEL1) interaction partners

  1. Cloned a bovine regulator of telomere length elongation helicase (RTEL) homolog and characterized its gene structure, expression distribution, splice variants and profile of DNA methylation around two putative transcription start sites.

RTEL1 抗原简介


In mice, inactivation of the Rtel (regulator of telomere length) gene has been shown to cause chromosome breaks, fusions, and telomere loss. In addition, Rtel is required for telomere elongation. Therefore, the mouse Rtel gene regulates chromosome stability and telomere length. This gene is the human ortholog of the mouse Rtel gene, so its protein product may play similar roles in humans. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B), generates a non-coding transcript. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with RTEL1

  • regulator of telomere elongation helicase 1 (RTEL1) 抗体
  • regulator of telomere elongation helicase 1 (rtel1) 抗体
  • RAD3-like DNA-binding helicase protein (AT1G79950) 抗体
  • regulator of telomere elongation helicase 1 (LOC100286037) 抗体
  • regulator of telomere elongation helicase 1 (Rtel1) 抗体
  • AI451565 抗体
  • AW540478 抗体
  • bK3184A7.3 抗体
  • C20orf41 抗体
  • DKCB5 抗体
  • F18B13.3 抗体
  • F18B13_3 抗体
  • NHL 抗体
  • RGD1306721 抗体
  • Rtel 抗体
  • zgc:113114 抗体

Protein level used designations for RTEL1

regulator of telomere elongation helicase 1 , helicase-like protein NHL , regulator of telomere length , DEAH helicase , regulator of telomere length helicase 1

419262 Gallus gallus
458415 Pan troglodytes
485976 Canis lupus familiaris
100540349 Meleagris gallopavo
100561075 Anolis carolinensis
844335 Arabidopsis thaliana
100286037 Zea mays
51750 Homo sapiens
269400 Mus musculus
362288 Rattus norvegicus
505721 Bos taurus
503732 Danio rerio
100171800 Pongo abelii
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