anti-Regenerating Islet-Derived Family, Member 4 (REG4) 抗体

Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. 再加上,我们可以发REG4 试剂盒 (35)REG4 蛋白 (21)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
REG4 445583 Q68AX7
REG4 83998 Q9BYZ8
REG4 67709 Q9D8G5
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antibodies-online.cn销售最多的anti-REG4 抗体

Showing 10 out of 44 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
非结合性 IHC, WB Immunohistochemical analysis of REG4 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. w Western blot analysis of REG4 expression in HEK293T (A), Raw264.7 (B), H9C2 (C) whole cell lysates. 200 μL 13至14个工作日
非结合性 ELISA, WB Western blot analysis of REG4 using HeLa whole cell lysates 100 μL 11至12个工作日
非结合性 ICC, IHC (fro), IHC (p), ELISA, WB 100 μg 13至16个工作日
非结合性 ELISA, IHC   100 μL Available
非结合性 ELISA   100 μL 14至16个工作日
小鼠 非结合性 WB Western blot analysis of extracts of various cell lines, using REG4 antibody. 200 μL 12至14个工作日
非结合性 ELISA   100 μL 14至16个工作日
大鼠 非结合性 ELISA, IHC (p) Immunochemical staining of rat REG4 in rat small intestine with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections). 100 μL 14至16个工作日
Biotin WB   100 μL 11至14个工作日
FITC WB   100 μL 11至14个工作日


Human Regenerating Islet-Derived Family, Member 4 (REG4) interaction partners

  1. REG4 plays an important role in KRAS-driven lung cancer pathogenesis and is a novel biomarker of lung adenocarcinoma subtype. Future studies are required to clarify the underlying mechanisms of REG4 in the division and proliferation of KC tumors and its potential therapeutic value.

  2. Our study demonstrated that Reg IV positively regulates the expression of SOX9 and is involved in tumor cell invasion and migration in gastric cancer.

  3. Reg4 inhibited apoptosis through regulating MAPK/Erk/Bim signaling pathway and thereby enhanced the resistance of gastric cancer to 5-Fluorouracil.

  4. Data indicate that REG4 tissue expression is a prognostic marker in subgroups of pancreatic ductal adenocarcinoma patients, and Serum REG4 level might be useful in differential diagnosis between pancreatic ductal adenocarcinoma and chronic pancreatitis.

  5. REG4 promotes peritoneal metastasis of gastric cancer through GPR37 and triggers a positive feedback loop.

  6. Study demonstrated that REG4, which is overexpressed in pancreatic ductal adenocarcinoma and secreted by cancer cells, promoted macrophage polarization to M2, through at least in part, activation of ERK1/2 and CREB.

  7. REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis.

  8. This study identifies REG4 as a potential serum biomarker for histotype-specific detection of mucinous ovarian cancer and suggests serum REG4 measurement as a non-invasive diagnostic tool for follow-up of patients with mucinous ovarian cancer.

  9. aberrant REG4 expression plays an essential role in early ovarian carcinogenesis and is closely linked to mucinous ovarian tumors, differentiation and adverse prognosis of ovarian cancer by modulating proliferation, apoptosis, migration and invasion.

  10. REG4 expression associated with favorable clinicopathological parameters and with higher overall survival from non-mucinous

  11. The Reg IV may be involved in the finetuning of functions exerted by the neuroendocrine cells in the GI-tract.

  12. Colorectal tumor patients with Reg4- and MMP-7-positive tumors had extremely poor overall survival.

  13. High expression of REG4 is associated with poor therapeutic response, adverse outcome and an aggressive phenotype in rectal cancer patients treated with neoadjuvant chemoradiotherapy.

  14. miR-24 functions as a novel tumor suppressor in gastric cancer, and the anti-oncogenic activity may involve its inhibition of the target gene REG4.

  15. REG4 expression is common in mucinous borderline ovarian tumors of the intestinal type as it is absent in the endocervical-like form tumors.

  16. the combination of VEGF-C and Reg IV may be a promising factor for clinical staging to supplement the classical TNM classification system.

  17. the stemness properties of control mammospheres and RegIV knockdown mammospheres were compared by tumourigenicity assay in vivo and plate colony formation assay in vitro.

  18. Reg4-induced mitogenesis involves Akt-GSK3beta-beta-Catenin-TCF-4 signaling in human colorectal cancer.

  19. Immunohistochemistry against known cell-type markers on serial sections has localised the expression of REGs to metaplastic Paneth cells (REG1A, REG1B and REG3A) and enteroendocrine cells (REG4), with a marked expansion of expression during inflammation.

  20. CDX2 protein directly regulates Reg IV expression in gastric cancer

Mouse (Murine) Regenerating Islet-Derived Family, Member 4 (REG4) interaction partners

  1. sorted Reg4(+) DCS cells promote organoid formation of single Lgr5(+) colon stem cells. DCS cells can be massively produced from Lgr5(+) colon stem cells in vitro by combined Notch inhibition and Wnt activation

  2. data suggest that Reg4 may protect against acinar cell necrosis in experimental pancreatitis by enhancing the expression of Bcl-2 and Bcl-xL via activation of the EGFR/Akt signalling pathway.

  3. Reg IV as an important modulator of gastrointestinal cell susceptibility to irradiation; hence, it is a potential target for adjunctive treatments for human colorectal cancer and other gastrointestinal malignancies.

  4. reg4 is amplified in the early stages of pancreatic cancer development

  5. Cloning and characterization of human REG4/RELP, in addition to cloning of mouse Reg4.

REG4 抗原简介


Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity).

Gene names and symbols associated with REG4

  • regenerating family member 4 (Reg4) 抗体
  • regenerating family member 4 (REG4) 抗体
  • regenerating islet-derived family, member 4 (Reg4) 抗体
  • 2010002L15Rik 抗体
  • GISP 抗体
  • REG-IV 抗体
  • RELP 抗体

Protein level used designations for REG4

REG-4 , regenerating islet-derived protein 4 , REG-like protein , gastrointestinal secretory protein , reg IV , regenerating gene type IV , regenerating islet-derived protein IV

445583 Rattus norvegicus
83998 Homo sapiens
67709 Mus musculus
100154580 Sus scrofa
767907 Bos taurus
100727547 Cavia porcellus
424379 Gallus gallus
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