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The protein encoded by RIPK4 is a serine/threonine protein kinase that interacts with protein kinase C-delta.
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Human Monoclonal RIPK4 Primary Antibody for ELISA, WB - ABIN565712
Adams, Munz: RIP4 is a target of multiple signal transduction pathways in keratinocytes: implications for epidermal differentiation and cutaneous wound repair. in Experimental cell research 2009
that loss of RIP4 enhances STAT3 (显示 STAT3 抗体) signaling in lung cancer cells
The patient with CHAND syndrome harbored the same mutation as the one identified in the family previously reported. We thus confirm the implication of RIPK4 gene in CHAND syndrome in addition to Bartsocas-Papas (显示 PSTPIP1 抗体) syndrome and discuss genotype/phenotype correlations.
CCL5 (显示 CCL5 抗体) and CXCL11 (显示 CXCL11 抗体) expression were also induced in response to the activation of the PKC (显示 PRRT2 抗体) pathway, and gene silencing experiments indicated that their inducible expression was dependent on RIPK4 and IRF6 (显示 IRF6 抗体). Moreover, gene reporter assays suggested that RIPK4 induces CCL5 (显示 CCL5 抗体) and CXCL11 (显示 CXCL11 抗体) expression by stimulating the transactivation of their promoters by IRF6 (显示 IRF6 抗体).
Overexpression of EZH2 (显示 EZH2 抗体) was found in 30 patients (76.9%) and was associated with FIGO stage, histological type, and lymph node metastasis (p < 0.05). In conclusion, our data suggest that RIPK4/EZH2 (显示 EZH2 抗体) markers might be used as potential predictors of prognosis in cervical cancer.
These findings position RIPK4 upstream of a hierarchal IRF6 (显示 IRF6 抗体)-GRHL3 (显示 GRHL3 抗体)-ELF3 (显示 ELF3 抗体) transcription factor pathway in keratinocytes.
CHAND and Bartsocas-Papas (显示 PSTPIP1 抗体) syndrome might be allelic disorders or RIPK4 mutations could confer varying degrees of phenotypic severity, depending on their localization within or outside functionally important domains.
we identified an epithelial ovarian cancer susceptibility loci at 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 x 10(-8))
The p.Ser376X mutation in RIPK4 impaired its induction of IRF6 (显示 IRF6 抗体) transactivator function.
Suppression of PKK expression by RNA interference inhibits phosphorylation of IKKalpha (显示 CHUK 抗体) and IKKbeta (显示 IKBKB 抗体) as well as activation of NF-kappaB (显示 NFKB1 抗体) in human cancer cell lines; thus, PKK regulates NF-kappaB (显示 NFKB1 抗体) activation by modulating activation of IKKalpha (显示 CHUK 抗体) and IKKbeta (显示 IKBKB 抗体).
The protein kinase C-associated kinase (PKK), which is also known as the receptor-interacting protein (显示 RIPK1 抗体) kinase (显示 CDK7 抗体) 4, is a suppressor of tumor growth in squamous cell carcinoma of the skin.
this work uncovers a critical role of PKK in lupus development
these results reveal a critical role of PKK in the maintenance of recirculating mature B cells as well as the development of B1 cells in mice
This approach identified a key signaling event, phosphorylation of a desmosome component, PKP1 (plakophilin-1 (显示 PKP1 抗体)) by RIPK4 (receptor-interacting serine-threonine kinase 4) during epidermal differentiation.
RIP4 functions in the epidermis through PKC-specific signaling pathways to regulate differentiation and inflammation
a member of the RICK/RIP (显示 HRB 抗体) family of kinases, which is involved in a PKC (显示 PKC 抗体)-activated NF-kappa B (显示 NFKB1 抗体) signaling pathway that is independent of Bcl10 (显示 BCL10 抗体) and IKK gamma (显示 IKBKG 抗体)
Data show that RIP4 is a critical component of a novel pathway that controls keratinocyte differentiation.
PKK may be required early in B cell development and for B cell receptor-mediated B cell proliferation.
PKK is not required for the production of B cells in the bone marrow or for the development and maintenance of all mature B lymphocyte (显示 AKAP17A 抗体) populations.
NF-kappaB (显示 NFKB1 抗体) activity and keratinocyte differentiation are regulated by the RIP4 protein, which has roles in cutaneous wound repair
The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation.
ankyrin repeat domain 3
, protein kinase PKK
, receptor-interacting serine/threonine-protein kinase 4
, receptor-interacting serine-threonine kinase 4
, receptor-interacting serine/threonine-protein kinase 4-like
, PKC-delta-interacting protein kinase
, ankyrin repeat domain-containing protein 3
, protein kinase C-associated kinase
, serine/threonine-protein kinase ANKRD3
, PKC-associated protein kinase
, PKC-regulated protein kinase