RecQ Protein-Like (DNA Helicase Q1-Like) 蛋白 (RECQL)

The protein encoded by RECQL is a member of the RecQ DNA helicase family. 再加上,我们可以发RecQ Protein-Like (DNA Helicase Q1-Like) 抗体 (21)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
RECQL 19691 Q9Z129
RECQL 5965 P46063
RECQL 312824 Q6AYJ1
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
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小麦胚 GST tag 2 μg Log in to see 11至12个工作日
$338.33
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酵母菌 大鼠 His tag   1 mg Log in to see 60至71个工作日
$3,793.17
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RECQL 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)

Human , ,
, ,
Rat (Rattus)

更多RecQ Protein-Like (DNA Helicase Q1-Like) (RECQL)互动伙伴

Mouse (Murine) RecQ Protein-Like (DNA Helicase Q1-Like) (RECQL) interaction partners

  1. Recql suppresses chromosomal instability.

Human RecQ Protein-Like (DNA Helicase Q1-Like) (RECQL) interaction partners

  1. Study detected five different RECQL mutation in six unrelated breast cancer patients. The identified mutations include one frame-shift deletion, two splicing site mutation and one nonsense mutation.

  2. RECQ1 is significantly overexpressed in multiple myeloma cells vs normal plasma cells. Increased RECQ1 expression is associated with poor prognosis. Its knockdown inhibits cell growth, increases apoptosis, and promotes DNA ds-breaks. Its overexpression protects against melphalan and bortezomib. It interacts with PARP1 (显示 PARP1 蛋白) and its loss sensitizes to PARP inhibitors.

  3. Data indicate that RECQL* c.1667_1667+3delAGTA is not a high-risk mutation for breast cancer though it could represent a moderate-risk breast cancer susceptibility allele.[meta-analysis]

  4. The authors have discovered a major sub-pathway of conventional long-patch base excision repair that involves formation of a 9-nucleotide gap 5' to the lesion. This new sub-pathway is mediated by RECQ1 DNA helicase and ERCC1 (显示 ERCC1 蛋白)-XPF (显示 ERCC4 蛋白) endonuclease in cooperation with PARP1 poly(ADP-ribose) polymerase (显示 PARP1 蛋白) and RPA (显示 RPA1 蛋白).

  5. We conclude that RECQL1 has prognostic and predictive significance in breast cancers.

  6. Our results indicate that the zinc binding motif in the RQC domain of RECQ1 is a key structural element that is essential for the structure-functions of RECQ1.

  7. Knockdown of RECQ1 significantly suppressed lung cancer cell proliferation, migration and invasion.

  8. To better understand the roles of RECQ1, two AL mutants (W227A and F231A) in full-length RECQ1 were characterized biochemically and genetically

  9. RECQL is a new breast cancer susceptibility gene.

  10. RECQL is a DNA helicase in breast cancer [editorial]

蛋白简介RecQ Protein-Like (DNA Helicase Q1-Like) (RECQL)

蛋白简介

The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. Some members of this family are associated with genetic disorders with predisposition to malignancy and chromosomal instability. The biological function of this helicase has not yet been determined. Two alternatively spliced transcripts, which encode the same isoform but differ in their 5' and 3' UTRs, have been described.

Gene names and symbols associated with RECQL

  • RecQ like helicase (RECQL)
  • RecQ helicase-like (recql)
  • ATP-dependent DNA helicase Q1 (CpipJ_CPIJ017275)
  • ATP-dependent DNA helicase Q1 (PAAG_01087)
  • RecQ like helicase (recql)
  • RecQ like helicase L homeolog (recql.L)
  • adenosylhomocysteinase pseudogene (LOC100151819)
  • RecQ protein-like (Recql)
  • RecQ like helicase (Recql)
  • DKFZp469B0921 蛋白
  • MGC131022 蛋白
  • recq1 蛋白
  • RECQL 蛋白
  • recql1 蛋白
  • zgc:110631 蛋白

Protein level used designations for RECQL

ATP-dependent DNA helicase Q1 , RecQ protein-like (DNA helicase Q1-like) , ATP-dependent DNA helicase Q1-like , DNA-dependent ATPase Q1 , recQ protein-like 1 , DNA helicase, RecQ-like type 1

GENE ID SPECIES
378910 Gallus gallus
533006 Bos taurus
566018 Danio rerio
6051087 Culex quinquefasciatus
9100521 Paracoccidioides sp. 'lutzii' Pb01
100171554 Pongo abelii
465334 Pan troglodytes
486641 Canis lupus familiaris
549070 Xenopus (Silurana) tropicalis
705871 Macaca mulatta
734924 Xenopus laevis
100011463 Monodelphis domestica
100068195 Equus caballus
100151819 Sus scrofa
100226344 Taeniopygia guttata
100470724 Ailuropoda melanoleuca
100586270 Nomascus leucogenys
19691 Mus musculus
5965 Homo sapiens
312824 Rattus norvegicus
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