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The protein encoded by RACGAP1 belongs to the GTPase-activating protein (GAP) family. 再加上，我们可以发RACGAP1 抗体 (126) 和 RACGAP1 蛋白 (7)和数多这个蛋白质的别的产品。
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MgcRacGAP SxIP motif is functionally important both for its role in regulating adherens junction structure during interphase and for regulating Rho GTPase activity during cytokinesis.
Study showed that a subset of epithelial ovarian cancer (EOC) patients have RacGAP1 overexpression which is associated with advanced tumor stages and poor clinical outcomes. Also, RacGAP1 can positively regulate the activation of RhoA (显示 RHOA ELISA试剂盒) and Erk (显示 EPHB2 ELISA试剂盒) proteins, thus up-enhance the migration and invasion process of EOC.
Data show that comparing with Ki-67 (显示 MKI67 ELISA试剂盒) and TOP2A (显示 TOP2A ELISA试剂盒), RacGAP1 allowed for a clearer prognostic statement.
RACGAP1 promotes the metastatic phenotype in uterine carcinosarcoma via a STAT3 (显示 STAT3 ELISA试剂盒)/survivin (显示 BIRC5 ELISA试剂盒) signaling pathway.
High RACGAP1 expression is associated with Basal-like Breast Cancers.
Data suggest that MGCRABGAP is involved in mammalian spermiogenesis by modulating RAB10 (显示 RAB10 ELISA试剂盒).
This study showed that the overexpressions of Ki67 (显示 MKI67 ELISA试剂盒), RacGAP1, and TOP2a (显示 TOP2A ELISA试剂盒) affect the prognosis of female breast cancer patients adversely
Data confirmed a strong correlation of AURKA (显示 AURKA ELISA试剂盒) and Wnt (显示 WNT2 ELISA试剂盒)-modulator RACGAP1 gene expression both in the gastric tumor, the tumor-adjacent and the tumor-distant mucosa.
RacGAP1 Is a Novel Downstream Effector of E2F7-Dependent Resistance to Doxorubicin and Is Prognostic for Overall Survival in Squamous Cell Carcinoma
RACGAP1 expression levels in the nucleus and cytoplasm, determined by immunohistochemical staining, predict opposite clinical outcomes and that both could be independent prognostic markers for colorectal cancer.
central spindle assembly and 2 Plk1-dependent phosphorylations are required to establish efficient binding of the Ect2 BRCT in early cytokinesis.
Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse.
APC (显示 APC ELISA试剂盒)(CDH1 (显示 CDH1 ELISA试剂盒)) targets MgcRacGAP for destruction in the late M phase.
TLR4 (显示 TLR4 ELISA试剂盒) signaling shapes B cell dynamics via MyD88 (显示 MYD88 ELISA试剂盒)-dependent pathways and Rac (显示 AKT1 ELISA试剂盒) GTPases.
several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac (显示 AKT1 ELISA试剂盒), CDC42 (显示 CDC42 ELISA试剂盒), and RhoG small GTPase activities
Rac (显示 AKT1 ELISA试剂盒) regulates vascular endothelial growth factor (显示 VEGF ELISA试剂盒) stimulated motility
These results indicate that MgcRacGAP regulates cytokinesis and cellular differentiation as a regulator of Rho family of GTPase and suggest that this process is controlled by some serine/threonine kinases.
alpha5 is required for proliferation and polarity of basal epithelial cells; the interaction between laminin-10/11-integrin alpha6beta4 and the PI3-kinase (显示 PIK3CA ELISA试剂盒)-Cdc42 (显示 CDC42 ELISA试剂盒)/Rac (显示 AKT1 ELISA试剂盒) pathways may play a role in determining the size and shape of tooth germ
Gab2 (显示 GAB2 ELISA试剂盒) via Shp-2 (显示 PTPN11 ELISA试剂盒) is critical for transmitting signals from Kit Tyr (显示 TYR ELISA试剂盒)(567) to activate the Rac (显示 AKT1 ELISA试剂盒)/JNK (显示 MAPK8 ELISA试剂盒) pathway controlling mast cell proliferation
Data demonstrate that normal cytokinesis in B lymphocytes requires the GAP and NH2 terminal domains but not GAP activity of mgcRacGAP.
Rac (显示 AKT1 ELISA试剂盒) became activated within 2 min after peripheral membrane extensions adhered to new ECM (显示 MMRN1 ELISA试剂盒) islands, and this activation wave propagated outward in an oriented manner as the cells spread from island to island
In vivo cell recordings reveal that gradual loss of wild-type RacGAP1 leads progressively from a failure of abscission, then to cleavage furrow ingression, and finally complete absence of furrow formation. Despite the lack of cytokinesis, gross patterning occurs overtly normally in ogre mutants and cells continue to cycle slowly, some even attaining four or eight nuclei.
The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene.
Rac GTPase activating protein 1
, rac GTPase-activating protein 1-like
, GTPase activating protein
, male germ cell RacGap
, protein CYK4 homolg
, protein CYK4 homolog
, rac GTPase-activating protein 1
, Rac GTPase-activating protein 1