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PURB product is a sequence-specific, single-stranded DNA-binding protein. 再加上，我们可以发Purine-Rich Element Binding Protein B 蛋白 (5) 和 Purine-Rich Element Binding Protein B 试剂盒 (3)和数多这个蛋白质的别的产品。
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site-directed mutagenesis revealed several basic amino acid residues in the intermolecular (R267) and intramolecular (K82 (显示 KRT82 抗体) and R159) subdomains that are essential for Purbeta transcriptional repressor function in Acta2 (显示 ACTA2 抗体) promoter-reporter assays. In keeping with their diminished Acta2 (显示 ACTA2 抗体) repressor activity in fibroblasts, purified Purbeta variants containing an R267A mutation exhibited reduced binding affinity for purine-ric (显示 FXYD5 抗体)...
This structural arrangement suggests that the cooperative assembly of the dimeric Purbeta repressor on the sense strand of the ACTA2 (显示 ACTA2 抗体) enhancer is dictated by the association of each subdomain with distinct purine-rich binding sites within the enhancer.
These findings suggest that the highly conserved modular repeats of Purbeta fold to form a core functional domain, which mediates the specific and high affinity binding of the protein to single-stranded DNA.
Overexpression of Purbeta, but not Puralpha (显示 PURA 抗体), significantly downregulated GnRH1 (显示 GNRH1 抗体) mRNA levels in transiently transfected GT1 (显示 MYL4 抗体)-7 cells, suggesting that Purbeta acts as a repressor of GnRH1 (显示 GNRH1 抗体) gene transcription.
Purbeta is a single-stranded DNA-binding repressor of vascular smooth muscle alpha-actin (显示 ACTA2 抗体) gene transcription
analysis of of DNA binding and localized strand separation by Pur alpha (显示 PURA 抗体) and comparison with Pur beta
Pur alpha (显示 PURA 抗体) and Pur beta repress smooth muscle alpha-actin (显示 ACTA2 抗体) gene transcription by means of DNA strand-selective cis (显示 CISH 抗体)-element binding and cell type-dependent protein-protein interactions
analysis of the quaternary structure of recombinant mouse Purbeta
These data demonstrate that Pur proteins collaborate with Sp3 (显示 SP3 抗体) to regulate a transcriptional program that enables muscle cells to remodel their phenotype.
structural role for certain core arginine residues in forming a conformationally stable Pur beta protein capable of physical interactions necessary for smooth muscle alpha-actin (显示 ACTA2 抗体) gene repression.
Suggest dynamic interplay between transcriptional activators Pur-alpha (显示 PURA 抗体)/Pur-beta and repressors in regulating SMalphaA (显示 ACTA2 抗体) gene output during myofibroblast differentiation.
results show that PUR proteins are capable of binding to alpha-MHC (显示 MYH6 抗体) mRNA and attenuate its translational efficiency; also show robust expression of PUR proteins in failing hearts where alpha-MHC (显示 MYH6 抗体) mRNA levels are suppressed
findings offer insights into mechanism, energetics, and sequence of Purbeta repressor binding to a biologically relevant, contractile phenotype-regulating cis (显示 CISH 抗体)-element while revealing the thermodynamic confines of Purbeta-mediated effects on DNA structure
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
purine-rich element-binding protein B
, transcription factor Pur-beta
, transcriptional activator protein Pur-beta
, PurB beta
, purine-rich single-stranded DNA-binding protein beta
, vascular actin single-stranded DNA-binding factor 2 p44 component
, purine-rich element-binding protein B-B
, transcriptional activator protein Pur-beta-B
, purine-rich element binding protein B