anti-Purine-Rich Element Binding Protein B (PURB) 抗体

PURB product is a sequence-specific, single-stranded DNA-binding protein. 再加上,我们可以发Purine-Rich Element Binding Protein B 试剂盒 (6)Purine-Rich Element Binding Protein B 蛋白 (6)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PURB 19291 O35295
PURB 498407 Q68A21
PURB 5814 Q96QR8
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Showing 10 out of 12 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-PURB Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  THP-1 cell lysate 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
非结合性 EIA, FACS, WB   0.4 mL Log in to see 2至3个工作日
$517.00
详细
非结合性 WB PURB antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 2至3个工作日
$473.93
详细
非结合性 FACS, IF, WB   400 μL Log in to see 7至9个工作日
$463.83
详细
非结合性 IP Immunoprecipitation: PURB Antibody [NBP1-99779] - Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-Pur-beta antibody NBP1-99779 used for IP at 6 ug/mg lysate. Pur-beta was also immunoprecipitated by rabbit anti-Pur-beta antibody NBP1-99780, which recognizes an upstream epitope. For blotting immunoprecipitated Pur-beta, NBP1-99779 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7至9个工作日
$556.31
详细
非结合性 IP Immunoprecipitation: PURB Antibody [NBP1-99780] - Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-Pur-beta antibody NBP1-99779 used for IP at 6 ug/mg lysate. Pur-beta was also immunoprecipitated by rabbit anti-Pur-beta antibody NBP1-99780, which recognizes an upstream epitope. For blotting immunoprecipitated Pur-beta, NBP1-99779 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7至9个工作日
$556.31
详细
非结合性 WB Western Blot: PURB Antibody [NBP1-70691] - THP-1 cell lysate, concentration 0.2-1 ug/ml. 100 μL Log in to see 8至11个工作日
$485.88
详细
非结合性 ELISA, WB   200 μL Log in to see 16 Days
$221.38
详细
Cow 非结合性 IP   100 μL Log in to see 7至9个工作日
$595.83
详细

通过反应活性、应用领域、克隆类型和共轭标记 PURB 抗体

特性 应用范围 宿主 克隆类型
Mouse (Murine) ,


Rat (Rattus) ,


Human ,


更多抗Purine-Rich Element Binding Protein B的相互作用对抗体

Mouse (Murine) Purine-Rich Element Binding Protein B (PURB) interaction partners

  1. site-directed mutagenesis revealed several basic amino acid residues in the intermolecular (R267) and intramolecular (K82 (显示 KRT82 抗体) and R159) subdomains that are essential for Purbeta transcriptional repressor function in Acta2 (显示 ACTA2 抗体) promoter-reporter assays. In keeping with their diminished Acta2 (显示 ACTA2 抗体) repressor activity in fibroblasts, purified Purbeta variants containing an R267A mutation exhibited reduced binding affinity for purine-ric (显示 FXYD5 抗体)...

  2. This structural arrangement suggests that the cooperative assembly of the dimeric Purbeta repressor on the sense strand of the ACTA2 (显示 ACTA2 抗体) enhancer is dictated by the association of each subdomain with distinct purine-rich binding sites within the enhancer.

  3. These findings suggest that the highly conserved modular repeats of Purbeta fold to form a core functional domain, which mediates the specific and high affinity binding of the protein to single-stranded DNA.

  4. Overexpression of Purbeta, but not Puralpha (显示 PURA 抗体), significantly downregulated GnRH1 (显示 GNRH1 抗体) mRNA levels in transiently transfected GT1 (显示 MYL4 抗体)-7 cells, suggesting that Purbeta acts as a repressor of GnRH1 (显示 GNRH1 抗体) gene transcription.

  5. Purbeta is a single-stranded DNA-binding repressor of vascular smooth muscle alpha-actin (显示 ACTA2 抗体) gene transcription

  6. analysis of of DNA binding and localized strand separation by Pur alpha (显示 PURA 抗体) and comparison with Pur beta

  7. Pur alpha (显示 PURA 抗体) and Pur beta repress smooth muscle alpha-actin (显示 ACTA2 抗体) gene transcription by means of DNA strand-selective cis (显示 CISH 抗体)-element binding and cell type-dependent protein-protein interactions

  8. analysis of the quaternary structure of recombinant mouse Purbeta

  9. These data demonstrate that Pur proteins collaborate with Sp3 (显示 SP3 抗体) to regulate a transcriptional program that enables muscle cells to remodel their phenotype.

  10. structural role for certain core arginine residues in forming a conformationally stable Pur beta protein capable of physical interactions necessary for smooth muscle alpha-actin (显示 ACTA2 抗体) gene repression.

Human Purine-Rich Element Binding Protein B (PURB) interaction partners

  1. site-directed mutagenesis revealed several basic amino acid residues in the intermolecular (R267) and intramolecular (K82 (显示 KRT82 抗体) and R159) subdomains that are essential for Purbeta transcriptional repressor function in Acta2 (显示 ACTA2 抗体) promoter-reporter assays. In keeping with their diminished Acta2 (显示 ACTA2 抗体) repressor activity in fibroblasts, purified Purbeta variants containing an R267A mutation exhibited reduced binding affinity for purine-ric (显示 FXYD5 抗体)...

  2. Suggest dynamic interplay between transcriptional activators Pur-alpha (显示 PURA 抗体)/Pur-beta and repressors in regulating SMalphaA (显示 ACTA2 抗体) gene output during myofibroblast differentiation.

  3. results show that PUR proteins are capable of binding to alpha-MHC (显示 MYH6 抗体) mRNA and attenuate its translational efficiency; also show robust expression of PUR proteins in failing hearts where alpha-MHC (显示 MYH6 抗体) mRNA levels are suppressed

  4. findings offer insights into mechanism, energetics, and sequence of Purbeta repressor binding to a biologically relevant, contractile phenotype-regulating cis (显示 CISH 抗体)-element while revealing the thermodynamic confines of Purbeta-mediated effects on DNA structure

Purine-Rich Element Binding Protein B (PURB) 抗原简介

蛋白简介

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.

Gene names and symbols associated with PURB

  • purine rich element binding protein B (Purb) 抗体
  • purine-rich element binding protein Bb (purbb) 抗体
  • purine-rich element binding protein B L homeolog (purb.L) 抗体
  • purine rich element binding protein B (PURB) 抗体
  • 2310015K15Rik 抗体
  • AA114818 抗体
  • Cager-2 抗体
  • D11Bwg0414e 抗体
  • pur-beta 抗体
  • purb 抗体
  • purb-b 抗体
  • PURBETA 抗体
  • zgc:65916 抗体

Protein level used designations for PURB

PurB beta , purine-rich element-binding protein B , purine-rich single-stranded DNA-binding protein beta , transcriptional activator protein Pur-beta , vascular actin single-stranded DNA-binding factor 2 p44 component , transcription factor Pur-beta , purine-rich element binding protein B , purine-rich element-binding protein B-B , transcriptional activator protein Pur-beta-B , LOW QUALITY PROTEIN: transcriptional activator protein Pur-beta

GENE ID SPECIES
19291 Mus musculus
498407 Rattus norvegicus
393519 Danio rerio
373775 Xenopus laevis
5814 Homo sapiens
504276 Bos taurus
100338406 Oryctolagus cuniculus
106558494 Canis lupus familiaris
106506852 Sus scrofa
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