anti-Programmed Cell Death 1 (PDCD1) 抗体

Human Programmed Cell Death 1 (PDCD1) interaction partners

1. We conclude that a subgroup of advanced disease ovarian cancer patients with high grade tumors, expressing PD-L1 (显示 CD274 抗体), may be prime candidates for immunotherapy targeting PD-1 signaling

2. Both rs2227982 and rs2227981 polymorphisms were associated with T1 Diabetes (T1D) risk in East Asians, and rs2227982 also had a significant association with glycemic traits, which suggested PDCD1 gene polymorphisms might participate in facilitating T1D risk. [meta-analysis]

3. The high-affinity PD-1 mutant could compete with the binding of antibodies specific to PD-L1 (显示 CD274 抗体) or PD-L2 (显示 PDCD1LG2 抗体) on cancer cells.

4. The G allele of rs36084323 of PDCD1 is associated with increased risk of advanced TNM (显示 ODZ1 抗体) staging of colorectal cancer.

5. promoter methylation of CTLA4, PD-L1, PD-L2, and PD-1 in diffuse lower-grade gliomas (LGG) harboring isocitrate dehydrogenase (IDH) mutation, is reported.

6. Unlike other multiple autoimmune disease associated genetic variants, there was no association between PDCD1 variants and Juvenile Idiopathic Arthritis

7. Alteration of the PD-1/PD-L1 (显示 CD274 抗体) pathway can modulate Treg/Th17 balance in asthmatic children.

8. The expression of PD1 on T cells was elevated in patients with rheumatoid arthritis and was correlated with the disease activity.

9. High expression of programmed death-1 in sentinel lymph nodes is associated with breast cancer.

10. We describe three cases of patients with mRCC treated with anti-PD-1 antibody therapy in combination with targeted therapy (bevacizumab), anti-cytotoxic T lymphocyte antigen 4 (显示 CTLA4 抗体) therapy (ipilimumab), or radiotherapy.

Cow (Bovine) Programmed Cell Death 1 (PDCD1) interaction partners

1. M. bovis infection increased the expression of the PD-1 receptor on total PBMCs and in gated CD4 (显示 CD4 抗体)(+) and CD8 (显示 CD8A 抗体)(+) T-cell subpopulations.

Mouse (Murine) Programmed Cell Death 1 (PDCD1) interaction partners

1. These results show that PD-1 plays an inhibitory role during the naive-to-effector CD8 (显示 CD8A 抗体) T cell transition and that the PD-1 pathway can also be modulated at this stage of T cell differentiation.

2. Blockade of CCR5-mediated myeloid derived suppressor cell accumulation enhances anti-PD1 efficacy in gastric cancer

3. T-cell activation mediates the immunopreventive effects of anti-PD-1; PD-1 on T cells interacts with the PD-1 ligand PD-L1 (显示 CD274 抗体) on cancer cells

4. these data show that PD-1 expression is an intrinsic property of brain-resident memory CD8 (显示 CD8A 抗体) T cells in a persistent CNS viral infection

5. Our results demonstrate that entinostat enhances the antitumor effect of PD-1 targeting through functional inhibition of MDSCs and a transition away from an immune-suppressive tumor microenvironment. These data provide a mechanistic rationale for the clinical testing and potential markers of response of this novel combination in solid tumor patients.

6. synergism in cell death by Caspase-1 (显示 CASP1 抗体)- and RipK3 (显示 RIPK3 抗体) resulted in restriction of PD-1 and TIM3 (显示 HAVCR2 抗体) expression on primed CD8 (显示 CD8A 抗体)(+) T cells, which promoted the survival of activated CD8 (显示 CD8A 抗体)(+) T cells.

7. Tim-3 (显示 HAVCR2 抗体) and PD-1 pathways play critical roles in regulating CD8 (显示 CD8A 抗体)(+) T cell function and maintaining normal pregnancy.

8. Anti-PD-1/PD-L1 (显示 CD274 抗体) therapy inhibited CMT167 orthotopic lung tumors by 95%. .Silencing PD-L1 (显示 CD274 抗体) expression in CMT167 cells resulted in smaller orthotopic tumors that remained sensitive to anti-PD-L1 (显示 CD274 抗体) therapy, whereas implantation of CMT167 cells into PD-L1 (显示 CD274 抗体)(-) mice blocked orthotopic tumor growth, indicating a role for PD-L1 (显示 CD274 抗体) in both the cancer cell and the microenvironment.

9. Combination therapies that depend on checkpoint inhibitor antibodies (Abs) such as for PD-1 or its ligand (PD-L1 (显示 CD274 抗体)) together with immune stimulatory agonist Abs like anti-OX40 (显示 TNFRSF4 抗体) are being tested in the clinic to achieve improved antitumor effects

10. Inhibition of Fut8 (显示 FUT8 抗体), a core fucosyltransferase, by genetic ablation or pharmacologic inhibition reduced cell-surface expression of PD-1 and enhanced T cell activation, leading to more efficient tumor eradication.

Rhesus Monkey Programmed Cell Death 1 (PDCD1) interaction partners

1. Data show that CTLA-4 (显示 CTLA4 抗体)(+)PD-1(-) memory CD4 (显示 CD4 抗体)(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut (显示 GUSB 抗体), and contained replication-competent and infectious virus.

2. Compared to before immunosuppression, PD-1 expression increased at reactivation. Increased T cells before zoster is likely due to virus reactivation.

3. A PD-1(high) phenotype is associated with accelerated in vivo CD8 (显示 CD8A 抗体) T cell turnover in SIV-infections, especially within the SIV-specific CD8 (显示 CD8A 抗体) T cell pool.

4. High levels of PD-1 expression on CD4 (显示 CD4 抗体)(+) T cells in lymph nodes of rhesus macaques can serve as a valuable marker to identify T follicular helper cells.

5. Data indicate that PD-1 expression is increased as a result of T cell activation during a primary immune response as well as during persistent immune activation in macaques.

6. PD-1 can serve as a sensitive indicator of persistent, low-level virus replication