anti-Programmed Cell Death 1 (PDCD1) 抗体

May have a role in the regulation of spermatogenesis.. 再加上,我们可以发PD-1 蛋白 (93)PD-1 试剂盒 (24)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PDCD1 5133 Q15116
PDCD1 301626  
PDCD1 18566 Q02242
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antibodies-online.cn销售最多的anti-PD-1 抗体

Showing 10 out of 655 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
小鼠 非结合性 BR, FACS   0.5 mg Log in to see 6至8个工作日
$271.98
详细
小鼠 Armenian Hamster 非结合性 BR, FACS, IP   0.1 mg Log in to see 6至8个工作日
$163.12
详细
山羊 非结合性 BR, CyTOF, ELISA (Capture), FACS, IHC, WB Detection of Human PD-1 by Western Blot. Western blot shows lysate of human thymus tissue. PVDF membrane was probed with 2 ug/mL of Goat Anti-Human PD-1 Antigen Affinity-purified Polyclonal Antibody. This experiment was conducted under reducing conditions. PD-1 in Human Lymph Node. PD-1 was detected in immersion fixed paraffin-embedded sections of human lymph node using Goat Anti-Human PD-1 Antigen Affinity-purified Polyclonal Antibody  at 3 ug/mL overnight at 4 ᄚC. Tissue was stained using the Anti-Goat HRP-DAB Cell & 100 μg Log in to see 8至9个工作日
$463.45
详细
山羊 非结合性 ELISA, WB ABIN185400 (0.6µg/ml) staining of Human Bone Marrow lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
$358.02
详细
山羊 Biotin ELISA (Detection), FACS, WB Detection of PD-1 in Human PBMCs treated with PHA by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) either (A) untreated or (B) treated with 5 ug/mL PHA overnight were stained with Goat Anti-Human PD-1 Biotinylated Antigen Affinity-purified Polyclonal Antibody. 50 μg Log in to see 8至9个工作日
$451.95
详细
非结合性 WB Anti-PD1 Picoband antibody ,  All lanes: Anti PD1  at 0.5ug/ml Lane 1: JURKAT Whole Cell Lysate at 40ug Lane 2: Human Placenta Tissue Lysate at 50ug Predicted bind size: 32KD Observed bind size: 38KD Anti-PD1 Picoband antibody ,  All lanes: Anti PD1  at 0.5ug/ml WB: Recombinant Human PD1 Protein 0.5ng Predicted bind size: 38KD Observed bind size: 38KD 100 μg Log in to see 4至6个工作日
$240.00
详细
小鼠 山羊 PE FACS Detection of PD-1 in Mouse CD4+ T-Cells by Flow Cytometry. Mouse CD4+ T-cells were stained with Goat Anti-Mouse PD-1 PE-conjugated Antigen Affinity-purified Polyclonal Antibody. 100 Tests Log in to see 8至9个工作日
$351.90
详细
非结合性 WB Western blot analysis of CD279 expression in THP1 (A), HepG2 (B), mouse liver (C), H9C2 (D) whole cell lysates. 200 μL Log in to see 13至14个工作日
$487.50
详细
小鼠 非结合性 EIA, WB 0.1 mL Log in to see 6至8个工作日
$412.50
详细
小鼠 非结合性 CyTOF, FACS, WB Detection of PD-1 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) either (A) untreated or (B) treated with 5 ng/mL PHA for 2 days were stained with Mouse Anti-Human PD-1 Monoclonal Antibody. Detection of Human PD-1 by Western Blot. Western blot shows lysates of HEK293 human embryonic kidney cell line either mock transfected or transfected with human PD-1. PVDF membrane was probed with 1 ug/mL of Mouse Anti-Human PD-1 Monoclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Log in to see 8至9个工作日
$346.15
详细

通过反应活性、应用领域、克隆类型和共轭标记 PDCD1 抗体

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引用最多的anti-PD-1 抗体

  1. Human Polyclonal PD-1 Primary Antibody for BR, CyTOF - ABIN5012979 : Wan, Nie, Liu, Feng, He, Xu, Zhang, Dong, Zhang: Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Show all 11 Pubmed References

  2. Human Polyclonal PD-1 Primary Antibody for ELISA (Detection), FACS - ABIN4899871 : Sakthivel, Ramanujam, Wang, Pirskanen, Lefvert: Programmed Death-1: from gene to protein in autoimmune human myasthenia gravis. in Journal of neuroimmunology 2008 (PubMed)
    Show all 9 Pubmed References

  3. Human Monoclonal PD-1 Primary Antibody for BR, FACS - ABIN2689142 : Bennett, Luxenberg, Ling, Wang, Marquette, Lowe, Khan, Veldman, Jacobs, Valge-Archer, Collins, Carreno: Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses. in Journal of immunology (Baltimore, Md. : 1950) 2003 (PubMed)
    Show all 8 Pubmed References

  4. Mouse (Murine) Monoclonal PD-1 Primary Antibody for BR, FACS - ABIN2689141 : Nishimura, Agata, Kawasaki, Sato, Imamura, Minato, Yagita, Nakano, Honjo: Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes. in International immunology 1997 (PubMed)
    Show all 7 Pubmed References

  5. Human Polyclonal PD-1 Primary Antibody for IHC, ELISA - ABIN1002980 : Holling, Schooten, van Den Elsen: Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. in Human immunology 2004 (PubMed)
    Show all 4 Pubmed References

  6. Human Polyclonal PD-1 Primary Antibody for IHC, ELISA - ABIN1002981 : Ishida, Agata, Shibahara, Honjo: Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. in The EMBO journal 1992 (PubMed)
    Show all 4 Pubmed References

  7. Human Monoclonal PD-1 Primary Antibody for ICC, FACS - ABIN438813 : Dorrell, Abraham, Lanxon-Cookson, Canaday, Streeter, Grompe: Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers. in Stem cell research 2009 (PubMed)
    Show all 3 Pubmed References

  8. Mouse (Murine) Polyclonal PD-1 Primary Antibody for CyTOF, FACS - ABIN4899873 : Kasagi, Kawano, Okazaki, Honjo, Morinobu, Hatachi, Shimatani, Tanaka, Minato, Kumagai: Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 3 Pubmed References

  9. Human Polyclonal PD-1 Primary Antibody for IF (p), IHC (p) - ABIN735608 : Zhang, Niyazi, Hong, Tuluwengjiang, Zhang, Zhang, Su, Bao: Effect of EBI3 on radiation-induced immunosuppression of cervical cancer HeLa cells by regulating Treg cells through PD-1/PD-L1 pathway. in Tumour biology 2017 (PubMed)
    Show all 2 Pubmed References

  10. Human Monoclonal PD-1 Primary Antibody for FACS - ABIN2479653 : Ochonisky, Chosidow, Kuentz, Man, Fraitag, Pelisse, Revuz: Cogan's syndrome. An unusual etiology of urticarial vasculitis. in Dermatologica 1992 (PubMed)
    Show all 3 Pubmed References

更多抗PD-1的相互作用对抗体

Human Programmed Cell Death 1 (PDCD1) interaction partners

  1. Early phase clinical trials using PD-1 or PD-L1 (显示 CD274 抗体) inhibitors alone or in combination have shown objective tumor responses and durable long-term disease control, in heavily pre-treated patients, notably in the TN subtype. Blockade of PD-1 or PD-L1 (显示 CD274 抗体) shows impressive antitumor activity in some subsets of breast cancer patients

  2. Differential expression of immunological markers relating to the PD-1/PD-L1 (显示 CD274 抗体) pathway in blood can be used as potential diagnostic and prognostic markers in ovarian cancers. These data have implications for the development and trial of anti-PD-1/PD-L1 (显示 CD274 抗体) therapy in ovarian cancer.

  3. LAG-3 (显示 LAG3 抗体)+ iTILs are enriched in estrogen receptor (显示 ESR1 抗体)-negative breast cancers and represent an independent favorable prognostic factor. In addition, a high proportion of PD-1/PD-L1 (显示 CD274 抗体)+ tumors are co-infiltrated with LAG-3 (显示 LAG3 抗体)+ TILs.

  4. An IDO1 (显示 IDO1 抗体) inhibitor, epacadostat also demonstrated promising activity in combination with the PD-1 checkpoint inhibitors in other solid tumors, including melanoma, urothelial carcinoma, renal cell carcinoma (显示 MOK 抗体), and non-small cell lung cancer

  5. PD-L1 (显示 CD274 抗体) was positive in tumor cells in 2/13 cases, weak positive in 7/13, and negative in 4/13 cases, respectively

  6. we report the first case of immune microenvironment profiling and response to anti-PD-1 in a patient with Renal medullary carcinoma to our knowledge. This case suggests that anti-PD-1 based therapies may have clinical activity in Renal medullary carcinoma

  7. We present two cases of metastatic melanoma treated with nivolumab and pembrolizumab (anti PD-1). Both patients developed acute interstitial nephritis during immune checkpoint therapy

  8. the positive rate of PD-L2 (显示 PDCD1LG2 抗体) did not show any differences between primary tumors and metastatic lymph nodes. In multivariate analysis, PD-L1 (显示 CD274 抗体) expression, PD-L2 (显示 PDCD1LG2 抗体) expression, a low density of CD8 (显示 CD8A 抗体)(+) T cells in primary tumors, and PD-1 expression on CD8 (显示 CD8A 抗体)(+) T cells in primary tumors were associated with poor prognosis.

  9. Relative to controls, the expression of PD-1 and PD-L1 (显示 CD274 抗体) on peripheral blood and tumor infiltrating T cells increased with disease progression. Upregulation of expression promotes t-cells apoptosis in gastric adenocarcinoma.

  10. These data support the combinatorial approach of in situ suppression of the PD-L inhibitory checkpoints with DC-mediated IL15 (显示 IL15 抗体) transpresentation to promote antigen-specific T-cell responses and, ultimately, contribute to graft-versus-tumor immunity

Mouse (Murine) Programmed Cell Death 1 (PDCD1) interaction partners

  1. Anti-PD-1/PD-L1 (显示 CD274 抗体) therapy inhibited CMT167 orthotopic lung tumors by 95%. .Silencing PD-L1 (显示 CD274 抗体) expression in CMT167 cells resulted in smaller orthotopic tumors that remained sensitive to anti-PD-L1 (显示 CD274 抗体) therapy, whereas implantation of CMT167 cells into PD-L1 (显示 CD274 抗体)(-) mice blocked orthotopic tumor growth, indicating a role for PD-L1 (显示 CD274 抗体) in both the cancer cell and the microenvironment.

  2. Combination therapies that depend on checkpoint inhibitor antibodies (Abs) such as for PD-1 or its ligand (PD-L1 (显示 CD274 抗体)) together with immune stimulatory agonist Abs like anti-OX40 (显示 TNFRSF4 抗体) are being tested in the clinic to achieve improved antitumor effects

  3. Inhibition of Fut8 (显示 FUT8 抗体), a core fucosyltransferase, by genetic ablation or pharmacologic inhibition reduced cell-surface expression of PD-1 and enhanced T cell activation, leading to more efficient tumor eradication.

  4. An examination of the mechanisms of immunity behind this long-term protection in PD-1 knockout mice showed a key role for parasite-specific CD8 (显示 CD8A 抗体)(+) T cells even when CD4 (显示 CD4 抗体)(+) T cells and B cells responded to re-infection.

  5. To test the in vivo activity of REGN2810, which does not cross-react with murine PD-1, knock-in mice were generated to express a hybrid protein containing the extracellular domain of human PD-1, and transmembrane and intracellular domains of mouse PD-1

  6. The combination of tumor vaccination to induce high avidity tumor specific T cell responses and PD-1 blockade synergises to provide tumor therapy and 85% survival in the aggressive B16 melanoma model.

  7. Blockade of PD-1 with monoclonal antibody may be an effective treatment during the postoperative period for restoring surgery-induced immunosuppression.

  8. Data suggest that genetic or environmental factors that even moderately affect the expression of both PD-1 and FoxP3 (显示 FOXP3 抗体) can cause life-threatening autoimmune diseases by disrupting the T-cell homeostasis.

  9. Data (including data from studies in transgenic/knockout mice) suggest that T-cell expression of Mirn155 is required to limit melanoma growth; miR (显示 MLXIP 抗体)-155, Pdcd1, Pdcd1l1 (显示 CD274 抗体), and Ctla4 (显示 CTLA4 抗体) appear to regulate overlapping pathways promoting antitumor immunity. [Mirn155 = microRNA 155; Pdcd1 = programmed cell death 1 protein; Pdcd1l1 (显示 CD274 抗体) = programmed cell death 1 ligand 1 (显示 CD274 抗体) protein; Ctla4 (显示 CTLA4 抗体) = cytotoxic T-lymphocyte-associated protein 4 (显示 CTLA4 抗体)]

  10. PD-1 plays a vital role in brain inflammation via regulation of Fgl-2 (显示 FGL2 抗体) after ICH (显示 ACE 抗体), and that manipulation of PD-1 might be a promising therapeutical target in ICH (显示 ACE 抗体).

Rhesus Monkey Programmed Cell Death 1 (PDCD1) interaction partners

  1. Data show that CTLA-4 (显示 CTLA4 抗体)(+)PD-1(-) memory CD4 (显示 CD4 抗体)(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut (显示 GUSB 抗体), and contained replication-competent and infectious virus.

  2. Compared to before immunosuppression, PD-1 expression increased at reactivation. Increased T cells before zoster is likely due to virus reactivation.

  3. A PD-1(high) phenotype is associated with accelerated in vivo CD8 (显示 CD8A 抗体) T cell turnover in SIV-infections, especially within the SIV-specific CD8 (显示 CD8A 抗体) T cell pool.

  4. High levels of PD-1 expression on CD4 (显示 CD4 抗体)(+) T cells in lymph nodes of rhesus macaques can serve as a valuable marker to identify T follicular helper cells.

  5. Data indicate that PD-1 expression is increased as a result of T cell activation during a primary immune response as well as during persistent immune activation in macaques.

  6. PD-1 can serve as a sensitive indicator of persistent, low-level virus replication

PD-1 (PDCD1) 抗原简介

蛋白简介

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

Gene names and symbols associated with PDCD1

  • programmed cell death 1 (PDCD1) 抗体
  • programmed cell death 1 (Pdcd1) 抗体
  • CD279 抗体
  • hPD-1 抗体
  • hPD-l 抗体
  • Ly101 抗体
  • PD-1 抗体
  • PD1 抗体
  • Pdc1 抗体
  • SLEB2 抗体

Protein level used designations for PDCD1

programmed cell death protein 1 , protein PD-1 , programmed cell death 1 , programmed death 1 , mPD-1

GENE ID SPECIES
5133 Homo sapiens
301626 Rattus norvegicus
424913 Gallus gallus
613842 Bos taurus
18566 Mus musculus
486213 Canis lupus familiaris
100135775 Macaca mulatta
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