anti-Programmed Cell Death 1 (PDCD1) 抗体

May have a role in the regulation of spermatogenesis.. 再加上,我们可以发PD-1 蛋白 (102)PD-1 试剂盒 (28)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PDCD1 5133 Q15116
PDCD1 301626  
PDCD1 18566 Q02242
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antibodies-online.cn销售最多的anti-PD-1 抗体

Showing 10 out of 708 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
小鼠 非结合性 BR, FACS   0.5 mg Log in to see 15至18个工作日
$388.79
详细
小鼠 Armenian Hamster 非结合性 BR, FACS, IP   0.1 mg Log in to see 15至18个工作日
$171.11
详细
小鼠 山羊 非结合性 CyTOF, FACS, IHC, WB PD-1 in Mouse Spleen. PD-1 was detected in perfusion fixed frozen sections of mouse spleen using Goat Anti-Mouse PD-1 Antigen Affinity-purified Polyclonal Antibody. Specific staining was localized to cytoplasm in splenocytes. PD-1 in Mouse Thymus. PD-1 was detected in perfusion fixed frozen sections of mouse thymus using 15 µ 100 μg Log in to see 8至9个工作日
$440.45
详细
山羊 非结合性 BR, CyTOF, ELISA (Capture), FACS, IHC, WB Detection of Human PD-1 by Western Blot. Western blot shows lysate of human thymus tissue. PVDF membrane was probed with 2 ug/mL of Goat Anti-Human PD-1 Antigen Affinity-purified Polyclonal Antibody. This experiment was conducted under reducing conditions. PD-1 in Human Lymph Node. PD-1 was detected in immersion fixed paraffin-embedded sections of human lymph node using Goat Anti-Human PD-1 Antigen Affinity-purified Polyclonal Antibody  at 3 ug/mL overnight at 4 ᄚC. Tissue was stained using the Anti-Goat HRP-DAB Cell & 100 μg Log in to see 8至9个工作日
$463.45
详细
山羊 非结合性 ELISA, WB ABIN185400 (0.6µg/ml) staining of Human Bone Marrow lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
$358.02
详细
山羊 Biotin ELISA (Detection), FACS, WB Detection of PD-1 in Human PBMCs treated with PHA by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) either (A) untreated or (B) treated with 5 ug/mL PHA overnight were stained with Goat Anti-Human PD-1 Biotinylated Antigen Affinity-purified Polyclonal Antibody. 50 μg Log in to see 8至9个工作日
$451.95
详细
非结合性 WB Anti-PD1 Picoband antibody ,  All lanes: Anti PD1  at 0.5ug/ml WB: Recombinant Human PD1 Protein 0.5ng Predicted bind size: 38KD Observed bind size: 38KD Anti-PD1 Picoband antibody , All lanes: Anti PD1  at 0.5ug/ml Lane 1: JURKAT Whole Cell Lysate at 40ug Lane 2: Human Placenta Tissue Lysate at 50ugPredicted bind size: 32KD Observed bind size: 38KD 100 μg Log in to see 4至6个工作日
$240.00
详细
小鼠 非结合性 IHC (p), WB PD1 was detected in paraffin-embedded sections of rat lymphaden tissues using rabbit anti- PD1 Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). PD1 was detected in paraffin-embedded sections of rat spleen tissues using rabbit anti- PD1 Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). 100 μg Log in to see 4至6个工作日
$280.00
详细
非结合性 WB Western blot analysis of CD279 expression in THP1 (A), HepG2 (B), mouse liver (C), H9C2 (D) whole cell lysates. 200 μL Log in to see 13至14个工作日
$487.50
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小鼠 非结合性 EIA, WB 0.1 mL Log in to see 6至8个工作日
$412.50
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引用最多的anti-PD-1 抗体

  1. Human Polyclonal PD-1 Primary Antibody for BR, CyTOF - ABIN5012979 : Wan, Nie, Liu, Feng, He, Xu, Zhang, Dong, Zhang: Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Show all 11 Pubmed References

  2. Human Polyclonal PD-1 Primary Antibody for ELISA (Detection), FACS - ABIN4899871 : Sakthivel, Ramanujam, Wang, Pirskanen, Lefvert: Programmed Death-1: from gene to protein in autoimmune human myasthenia gravis. in Journal of neuroimmunology 2008 (PubMed)
    Show all 9 Pubmed References

  3. Human Monoclonal PD-1 Primary Antibody for BR, FACS - ABIN2689142 : Bennett, Luxenberg, Ling, Wang, Marquette, Lowe, Khan, Veldman, Jacobs, Valge-Archer, Collins, Carreno: Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses. in Journal of immunology (Baltimore, Md. : 1950) 2003 (PubMed)
    Show all 8 Pubmed References

  4. Mouse (Murine) Monoclonal PD-1 Primary Antibody for BR, FACS - ABIN2689141 : Nishimura, Agata, Kawasaki, Sato, Imamura, Minato, Yagita, Nakano, Honjo: Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes. in International immunology 1997 (PubMed)
    Show all 7 Pubmed References

  5. Human Polyclonal PD-1 Primary Antibody for IHC, ELISA - ABIN1002980 : Holling, Schooten, van Den Elsen: Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. in Human immunology 2004 (PubMed)
    Show all 4 Pubmed References

  6. Human Polyclonal PD-1 Primary Antibody for IHC, ELISA - ABIN1002981 : Ishida, Agata, Shibahara, Honjo: Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. in The EMBO journal 1992 (PubMed)
    Show all 4 Pubmed References

  7. Mouse (Murine) Polyclonal PD-1 Primary Antibody for CyTOF, FACS - ABIN4899873 : Kasagi, Kawano, Okazaki, Honjo, Morinobu, Hatachi, Shimatani, Tanaka, Minato, Kumagai: Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 3 Pubmed References

  8. Human Monoclonal PD-1 Primary Antibody for ICC, FACS - ABIN438813 : Dorrell, Abraham, Lanxon-Cookson, Canaday, Streeter, Grompe: Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers. in Stem cell research 2009 (PubMed)
    Show all 3 Pubmed References

  9. Human Polyclonal PD-1 Primary Antibody for IF (p), IHC (p) - ABIN735608 : Zhang, Niyazi, Hong, Tuluwengjiang, Zhang, Zhang, Su, Bao: Effect of EBI3 on radiation-induced immunosuppression of cervical cancer HeLa cells by regulating Treg cells through PD-1/PD-L1 pathway. in Tumour biology 2017 (PubMed)
    Show all 2 Pubmed References

  10. Human Monoclonal PD-1 Primary Antibody for FACS - ABIN2479653 : Ochonisky, Chosidow, Kuentz, Man, Fraitag, Pelisse, Revuz: Cogan's syndrome. An unusual etiology of urticarial vasculitis. in Dermatologica 1992 (PubMed)
    Show all 3 Pubmed References

更多抗PD-1的相互作用对抗体

Human Programmed Cell Death 1 (PDCD1) interaction partners

  1. We conclude that a subgroup of advanced disease ovarian cancer patients with high grade tumors, expressing PD-L1 (显示 CD274 抗体), may be prime candidates for immunotherapy targeting PD-1 signaling

  2. Both rs2227982 and rs2227981 polymorphisms were associated with T1 Diabetes (T1D) risk in East Asians, and rs2227982 also had a significant association with glycemic traits, which suggested PDCD1 gene polymorphisms might participate in facilitating T1D risk. [meta-analysis]

  3. The high-affinity PD-1 mutant could compete with the binding of antibodies specific to PD-L1 (显示 CD274 抗体) or PD-L2 (显示 PDCD1LG2 抗体) on cancer cells.

  4. The G allele of rs36084323 of PDCD1 is associated with increased risk of advanced TNM (显示 ODZ1 抗体) staging of colorectal cancer.

  5. promoter methylation of CTLA4, PD-L1, PD-L2, and PD-1 in diffuse lower-grade gliomas (LGG) harboring isocitrate dehydrogenase (IDH) mutation, is reported.

  6. Unlike other multiple autoimmune disease associated genetic variants, there was no association between PDCD1 variants and Juvenile Idiopathic Arthritis

  7. Alteration of the PD-1/PD-L1 (显示 CD274 抗体) pathway can modulate Treg/Th17 balance in asthmatic children.

  8. The expression of PD1 on T cells was elevated in patients with rheumatoid arthritis and was correlated with the disease activity.

  9. High expression of programmed death-1 in sentinel lymph nodes is associated with breast cancer.

  10. We describe three cases of patients with mRCC treated with anti-PD-1 antibody therapy in combination with targeted therapy (bevacizumab), anti-cytotoxic T lymphocyte antigen 4 (显示 CTLA4 抗体) therapy (ipilimumab), or radiotherapy.

Cow (Bovine) Programmed Cell Death 1 (PDCD1) interaction partners

  1. M. bovis infection increased the expression of the PD-1 receptor on total PBMCs and in gated CD4 (显示 CD4 抗体)(+) and CD8 (显示 CD8A 抗体)(+) T-cell subpopulations.

Mouse (Murine) Programmed Cell Death 1 (PDCD1) interaction partners

  1. These results show that PD-1 plays an inhibitory role during the naive-to-effector CD8 (显示 CD8A 抗体) T cell transition and that the PD-1 pathway can also be modulated at this stage of T cell differentiation.

  2. Blockade of CCR5-mediated myeloid derived suppressor cell accumulation enhances anti-PD1 efficacy in gastric cancer

  3. T-cell activation mediates the immunopreventive effects of anti-PD-1; PD-1 on T cells interacts with the PD-1 ligand PD-L1 (显示 CD274 抗体) on cancer cells

  4. these data show that PD-1 expression is an intrinsic property of brain-resident memory CD8 (显示 CD8A 抗体) T cells in a persistent CNS viral infection

  5. Our results demonstrate that entinostat enhances the antitumor effect of PD-1 targeting through functional inhibition of MDSCs and a transition away from an immune-suppressive tumor microenvironment. These data provide a mechanistic rationale for the clinical testing and potential markers of response of this novel combination in solid tumor patients.

  6. synergism in cell death by Caspase-1 (显示 CASP1 抗体)- and RipK3 (显示 RIPK3 抗体) resulted in restriction of PD-1 and TIM3 (显示 HAVCR2 抗体) expression on primed CD8 (显示 CD8A 抗体)(+) T cells, which promoted the survival of activated CD8 (显示 CD8A 抗体)(+) T cells.

  7. Tim-3 (显示 HAVCR2 抗体) and PD-1 pathways play critical roles in regulating CD8 (显示 CD8A 抗体)(+) T cell function and maintaining normal pregnancy.

  8. Anti-PD-1/PD-L1 (显示 CD274 抗体) therapy inhibited CMT167 orthotopic lung tumors by 95%. .Silencing PD-L1 (显示 CD274 抗体) expression in CMT167 cells resulted in smaller orthotopic tumors that remained sensitive to anti-PD-L1 (显示 CD274 抗体) therapy, whereas implantation of CMT167 cells into PD-L1 (显示 CD274 抗体)(-) mice blocked orthotopic tumor growth, indicating a role for PD-L1 (显示 CD274 抗体) in both the cancer cell and the microenvironment.

  9. Combination therapies that depend on checkpoint inhibitor antibodies (Abs) such as for PD-1 or its ligand (PD-L1 (显示 CD274 抗体)) together with immune stimulatory agonist Abs like anti-OX40 (显示 TNFRSF4 抗体) are being tested in the clinic to achieve improved antitumor effects

  10. Inhibition of Fut8 (显示 FUT8 抗体), a core fucosyltransferase, by genetic ablation or pharmacologic inhibition reduced cell-surface expression of PD-1 and enhanced T cell activation, leading to more efficient tumor eradication.

Rhesus Monkey Programmed Cell Death 1 (PDCD1) interaction partners

  1. Data show that CTLA-4 (显示 CTLA4 抗体)(+)PD-1(-) memory CD4 (显示 CD4 抗体)(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut (显示 GUSB 抗体), and contained replication-competent and infectious virus.

  2. Compared to before immunosuppression, PD-1 expression increased at reactivation. Increased T cells before zoster is likely due to virus reactivation.

  3. A PD-1(high) phenotype is associated with accelerated in vivo CD8 (显示 CD8A 抗体) T cell turnover in SIV-infections, especially within the SIV-specific CD8 (显示 CD8A 抗体) T cell pool.

  4. High levels of PD-1 expression on CD4 (显示 CD4 抗体)(+) T cells in lymph nodes of rhesus macaques can serve as a valuable marker to identify T follicular helper cells.

  5. Data indicate that PD-1 expression is increased as a result of T cell activation during a primary immune response as well as during persistent immune activation in macaques.

  6. PD-1 can serve as a sensitive indicator of persistent, low-level virus replication

PD-1 (PDCD1) 抗原简介

蛋白简介

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

Gene names and symbols associated with PDCD1

  • programmed cell death 1 (PDCD1) 抗体
  • programmed cell death 1 (Pdcd1) 抗体
  • CD279 抗体
  • hPD-1 抗体
  • hPD-l 抗体
  • Ly101 抗体
  • PD-1 抗体
  • PD1 抗体
  • Pdc1 抗体
  • SLEB2 抗体

Protein level used designations for PDCD1

programmed cell death protein 1 , protein PD-1 , programmed cell death 1 , programmed death 1 , mPD-1

GENE ID SPECIES
5133 Homo sapiens
301626 Rattus norvegicus
424913 Gallus gallus
613842 Bos taurus
18566 Mus musculus
486213 Canis lupus familiaris
100135775 Macaca mulatta
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