anti-Programmed Cell Death 1 (PDCD1) 抗体

May have a role in the regulation of spermatogenesis.. 再加上,我们可以发PD-1 蛋白 (91)PD-1 试剂盒 (26)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PDCD1 5133 Q15116
PDCD1 301626  
PDCD1 18566 Q02242
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antibodies-online.cn销售最多的anti-PD-1 抗体

Showing 10 out of 657 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 WB Anti-PD1 Picoband antibody ,  All lanes: Anti PD1  at 0.5ug/ml Lane 1: JURKAT Whole Cell Lysate at 40ug Lane 2: Human Placenta Tissue Lysate at 50ug Predicted bind size: 32KD Observed bind size: 38KD Anti-PD1 Picoband antibody ,  All lanes: Anti PD1  at 0.5ug/ml WB: Recombinant Human PD1 Protein 0.5ng Predicted bind size: 38KD Observed bind size: 38KD 100 μg Log in to see 4至6个工作日
$240.00
详细
小鼠 山羊 PE FACS Detection of PD-1 in Mouse CD4+ T-Cells by Flow Cytometry. Mouse CD4+ T-cells were stained with Goat Anti-Mouse PD-1 PE-conjugated Antigen Affinity-purified Polyclonal Antibody. 100 Tests Log in to see 8至9个工作日
$351.90
详细
山羊 Biotin ELISA (Detection), FACS, WB Detection of PD-1 in Human PBMCs treated with PHA by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) either (A) untreated or (B) treated with 5 ug/mL PHA overnight were stained with Goat Anti-Human PD-1 Biotinylated Antigen Affinity-purified Polyclonal Antibody. 50 μg Log in to see 8至9个工作日
$451.95
详细
小鼠 山羊 非结合性 CyTOF, FACS, IHC, WB PD-1 in Mouse Spleen. PD-1 was detected in perfusion fixed frozen sections of mouse spleen using Goat Anti-Mouse PD-1 Antigen Affinity-purified Polyclonal Antibody. Specific staining was localized to cytoplasm in splenocytes. PD-1 in Mouse Thymus. PD-1 was detected in perfusion fixed frozen sections of mouse thymus using 15 µ 100 μg Log in to see 8至9个工作日
$440.45
详细
非结合性 WB Western blot analysis of CD279 expression in THP1 (A), HepG2 (B), mouse liver (C), H9C2 (D) whole cell lysates. 200 μL Log in to see 13至14个工作日
$487.50
详细
山羊 非结合性 ELISA, WB ABIN185400 (0.6µg/ml) staining of Human Bone Marrow lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
$358.02
详细
小鼠 非结合性 EIA, WB 0.1 mL Log in to see 6至8个工作日
$412.50
详细
小鼠 仓鼠 Biotin FACS 0.1 mg Log in to see 6至8个工作日
$308.00
详细
小鼠 仓鼠 非结合性 FACS 0.25 mg Log in to see 6至8个工作日
$379.50
详细
小鼠 非结合性 CyTOF, FACS, WB Detection of PD-1 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) either (A) untreated or (B) treated with 5 ng/mL PHA for 2 days were stained with Mouse Anti-Human PD-1 Monoclonal Antibody. Detection of Human PD-1 by Western Blot. Western blot shows lysates of HEK293 human embryonic kidney cell line either mock transfected or transfected with human PD-1. PVDF membrane was probed with 1 ug/mL of Mouse Anti-Human PD-1 Monoclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Log in to see 8至9个工作日
$346.15
详细

通过反应活性、应用领域、克隆类型和共轭标记 PDCD1 抗体

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引用最多的anti-PD-1 抗体

  1. Human Monoclonal PD-1 Primary Antibody for BR, FACS - ABIN2689142 : Bennett, Luxenberg, Ling, Wang, Marquette, Lowe, Khan, Veldman, Jacobs, Valge-Archer, Collins, Carreno: Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses. in Journal of immunology (Baltimore, Md. : 1950) 2003 (PubMed)
    Show all 8 Pubmed References

  2. Human Polyclonal PD-1 Primary Antibody for ELISA (Detection), FACS - ABIN4899871 : Sakthivel, Ramanujam, Wang, Pirskanen, Lefvert: Programmed Death-1: from gene to protein in autoimmune human myasthenia gravis. in Journal of neuroimmunology 2008 (PubMed)
    Show all 7 Pubmed References

  3. Mouse (Murine) Monoclonal PD-1 Primary Antibody for BR, FACS - ABIN2689141 : Nishimura, Agata, Kawasaki, Sato, Imamura, Minato, Yagita, Nakano, Honjo: Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes. in International immunology 1997 (PubMed)
    Show all 7 Pubmed References

  4. Human Polyclonal PD-1 Primary Antibody for IHC, ELISA - ABIN1002980 : Holling, Schooten, van Den Elsen: Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. in Human immunology 2004 (PubMed)
    Show all 4 Pubmed References

  5. Human Polyclonal PD-1 Primary Antibody for IHC, ELISA - ABIN1002981 : Ishida, Agata, Shibahara, Honjo: Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. in The EMBO journal 1992 (PubMed)
    Show all 4 Pubmed References

  6. Mouse (Murine) Polyclonal PD-1 Primary Antibody for CyTOF, FACS - ABIN4899873 : Kasagi, Kawano, Okazaki, Honjo, Morinobu, Hatachi, Shimatani, Tanaka, Minato, Kumagai: Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal PD-1 Primary Antibody for ICC, FACS - ABIN438813 : Dorrell, Abraham, Lanxon-Cookson, Canaday, Streeter, Grompe: Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers. in Stem cell research 2009 (PubMed)
    Show all 2 Pubmed References

  8. Mouse (Murine) Monoclonal PD-1 Primary Antibody for IHC (fro), FACS - ABIN2479661 : Yamaoka, Furusawa, Fujimoto, Iguchi, Kumai: Muscle spindles in the mylohyoid muscle of rats. in International journal of oral and maxillofacial surgery 1992 (PubMed)
    Show all 3 Pubmed References

  9. Human Monoclonal PD-1 Primary Antibody for FACS - ABIN2479652 : Ochonisky, Chosidow, Kuentz, Man, Fraitag, Pelisse, Revuz: Cogan's syndrome. An unusual etiology of urticarial vasculitis. in Dermatologica 1992 (PubMed)
    Show all 3 Pubmed References

  10. Human Monoclonal PD-1 Primary Antibody for FACS - ABIN2479654 : Kanai, Totsuka, Uraushihara, Makita, Nakamura, Koganei, Fukushima, Akiba, Yagita, Okumura, Machida, Iwai, Azuma, Chen, Watanabe: Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. in Journal of immunology (Baltimore, Md. : 1950) 2003 (PubMed)
    Show all 3 Pubmed References

更多抗PD-1的相互作用对抗体

Human Programmed Cell Death 1 (PDCD1) interaction partners

  1. Report hyperprogression/reduced progression-free survival during anti-PD-1/PD-L1 (显示 CD274 抗体) therapy in patients with recurrent and/or metastatic head and neck squamous cell carcinoma.

  2. Data indicate clinical responses to PD-1 blockade occur in prostate cancer patients progressing on enzalutamide.

  3. Results showed that high CTLA4 (显示 CTLA4 抗体) but low PD-1 expression were associated with a poor overall survival of patients with breast cancer.

  4. Surface expression of PD-1 on CD4 (显示 CD4 抗体)+ T cells has a prognostic value in non-small cell lung cancer patients, as high expression of PD-1 is associated with a shorter progression-free survival and overall survival.

  5. results not only provide a foundation for further assessment of PD-L1 (显示 CD274 抗体) immunohistochemistry as a predictive marker for anti-PD-1 therapy in colorectal carcinoma

  6. Blimp-1 (显示 PRDM1 抗体) binds to the promoters of PD-1 and TIGIT (显示 TIGIT 抗体) and positively regulates their expression in patients with acute myeloid leukemia (显示 BCL11A 抗体).

  7. high PD-L1 (显示 CD274 抗体) expression by tumor cells was associated with favorable prognosis, whereas an increased number of PD-1+ TILs was correlated with poor prognosis in thymic carcinoma.

  8. The majority of primary penile penile squamous cell carcinoma (SqCC) tumors express PD-L1 (显示 CD274 抗体), which is associated with high-risk clinicopathologic features and poor clinical outcome. These data provide a rational basis for further investigation of anti-PD-1 and anti-PD-L1 (显示 CD274 抗体) immunotherapeutics in patients with advanced penile SqCC

  9. Of several immunotherapies being investigated, antibodies that target the programmed cell death protein-1 (nivolumab and pembrolizumab) and cytotoxic T-lymphocyte antigen-4 (显示 CTLA4 抗体) (ipilimumab) immune checkpoint pathways are among the most promising for patients with Small cell lung cancer (SCLC), and are the focus of this review.

  10. In this review, we discuss deepening insights into human genetics and our understanding of the interface with rheumatoid arthritis pathogenesis providing a strong rationale for exploiting the co-inhibitory receptor programmed cell death-1 signaling pathway as a better approach for the treatment of this chronic, often progressive destructive joint disease.

Mouse (Murine) Programmed Cell Death 1 (PDCD1) interaction partners

  1. Data (including data from studies in transgenic/knockout mice) suggest that T-cell expression of Mirn155 is required to limit melanoma growth; miR (显示 MLXIP 抗体)-155, Pdcd1, Pdcd1l1 (显示 CD274 抗体), and Ctla4 (显示 CTLA4 抗体) appear to regulate overlapping pathways promoting antitumor immunity. [Mirn155 = microRNA 155; Pdcd1 = programmed cell death 1 protein; Pdcd1l1 (显示 CD274 抗体) = programmed cell death 1 ligand 1 (显示 CD274 抗体) protein; Ctla4 (显示 CTLA4 抗体) = cytotoxic T-lymphocyte-associated protein 4 (显示 CTLA4 抗体)]

  2. PD-1 plays a vital role in brain inflammation via regulation of Fgl-2 (显示 FGL2 抗体) after ICH (显示 ACE 抗体), and that manipulation of PD-1 might be a promising therapeutical target in ICH (显示 ACE 抗体).

  3. We identified PD-1 to be specifically expressed in PLZF (显示 ZBTB16 抗体)(+) ILCp and revealed that the timing and order of expression of the transcription factors NFIL3 (显示 NFIL3 抗体), ID2, and TCF-1 (显示 HNF1A 抗体) was critical. Importantly, induction of ILC (显示 CCL27 抗体) lineage commitment required only transient expression of NFIL3 (显示 NFIL3 抗体) prior to ID2 and TCF-1 (显示 HNF1A 抗体) expression.

  4. The identification of the role for PD-1 in regulating B cell-dependent antitumor immunity to Tn antigen highlights an opportunity to develop new therapeutic strategies targeting tumor-associated carbohydrate antigens

  5. These findings suggest that PD-1 pathway blockade may reverse adaptive immune resistance following cyclic dinucleotide treatment, enhancing both local and systemic antitumor immunity.

  6. data suggest that increased expression of checkpoint blockade molecules PD-1 and CTLA-4 (显示 CTLA4 抗体) on donor T cells is not sufficient to prevent GvHD, and that cooperation between checkpoint blockade signaling by host cells and donor Tregs is necessary to limit GvHD in allo-HSCT recipients

  7. PD-1 Blockade Promotes Epitope Spreading in Anticancer CD8 (显示 CD8A 抗体)(+) T Cell Responses by Preventing Fratricidal Death of Subdominant Clones To Relieve Immunodomination

  8. Adoptive transfer of murine T cells expressing a chimeric-PD1-Dap10 (显示 HCST 抗体) receptor may induce a preferential cytokine profile and T-cell differentiation phenotype for anti-lymphoma therapies.

  9. soluble PD-1 is elevated in critical illness and may represent a potential biomarker for Acute respiratory distress syndrome.

  10. Together, our results suggest an important role of PD-1 in glioma-induced immune escape, and provide translational evidence for the use of PD-1 blocking antibodies in human malignant gliomas.

Rhesus Monkey Programmed Cell Death 1 (PDCD1) interaction partners

  1. Data show that CTLA-4 (显示 CTLA4 抗体)(+)PD-1(-) memory CD4 (显示 CD4 抗体)(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut (显示 GUSB 抗体), and contained replication-competent and infectious virus.

  2. Compared to before immunosuppression, PD-1 expression increased at reactivation. Increased T cells before zoster is likely due to virus reactivation.

  3. A PD-1(high) phenotype is associated with accelerated in vivo CD8 (显示 CD8A 抗体) T cell turnover in SIV-infections, especially within the SIV-specific CD8 (显示 CD8A 抗体) T cell pool.

  4. High levels of PD-1 expression on CD4 (显示 CD4 抗体)(+) T cells in lymph nodes of rhesus macaques can serve as a valuable marker to identify T follicular helper cells.

  5. Data indicate that PD-1 expression is increased as a result of T cell activation during a primary immune response as well as during persistent immune activation in macaques.

  6. PD-1 can serve as a sensitive indicator of persistent, low-level virus replication

PD-1 (PDCD1) 抗原简介

蛋白简介

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

Gene names and symbols associated with PDCD1

  • programmed cell death 1 (PDCD1) 抗体
  • programmed cell death 1 (Pdcd1) 抗体
  • CD279 抗体
  • hPD-1 抗体
  • hPD-l 抗体
  • Ly101 抗体
  • PD-1 抗体
  • PD1 抗体
  • Pdc1 抗体
  • SLEB2 抗体

Protein level used designations for PDCD1

programmed cell death protein 1 , protein PD-1 , programmed cell death 1 , programmed death 1 , mPD-1

GENE ID SPECIES
5133 Homo sapiens
301626 Rattus norvegicus
424913 Gallus gallus
613842 Bos taurus
18566 Mus musculus
486213 Canis lupus familiaris
100135775 Macaca mulatta
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