anti-Programmed Cell Death 1 (PDCD1) 抗体

Human Programmed Cell Death 1 (PDCD1) interaction partners

1. Alteration of the PD-1/PD-L1 (显示 CD274 抗体) pathway can modulate Treg/Th17 balance in asthmatic children.

2. The expression of PD1 on T cells was elevated in patients with rheumatoid arthritis and was correlated with the disease activity.

3. High expression of programmed death-1 in sentinel lymph nodes is associated with breast cancer.

4. We describe three cases of patients with mRCC treated with anti-PD-1 antibody therapy in combination with targeted therapy (bevacizumab), anti-cytotoxic T lymphocyte antigen 4 (显示 CTLA4 抗体) therapy (ipilimumab), or radiotherapy.

5. anti-CTLA4 (显示 CTLA4 抗体)/anti-PD-1/PD-L1 (显示 CD274 抗体) combinations versus anti-PD-1/PD-L1 (显示 CD274 抗体) monotherapy was selected as a factor independent of TMB (显示 MRPL55 抗体) for predicting better RR (77% vs. 21%; P = 0.004) and PFS (P = 0.024). Higher TMB (显示 MRPL55 抗体) predicts favorable outcome to PD-1/PD-L1 (显示 CD274 抗体) blockade across diverse tumors.

6. The altered soluble (s)PD1 and sICOS serum levels in the different Hepatitis b (HBV) groups may reflect the dysregulation of T cell activation, and may be associated with the HBV pathological process.

7. We found that PD-L1 (显示 CD274 抗体) expression was upregulated following TGF-beta (显示 TGFB1 抗体) induction; in contrast, it was downregulated by TGF-beta (显示 TGFB1 抗体) receptor-kinase inhibitors and the MET process. Furthermore, chemo-treatment increased TGF-beta (显示 TGFB1 抗体) expression and enhances PD-L1 (显示 CD274 抗体) expression via autocrine TGF-beta (显示 TGFB1 抗体) induced EMT (显示 ITK 抗体). Analysis of clinical samples revealed a significant relationship between PD-L1 (显示 CD274 抗体) expression and EMT (显示 ITK 抗体) status

8. this study demonstrated that PD-1 may involve in lymph nodes metastasis and promote the understanding of the mechanism of immunotherapies in the non-small cell lung cancer

9. PD-L1 (显示 CD274 抗体) expression in melanoma tumor cells is lower than NSCLC or renal cell carcinoma (显示 MOK 抗体) cells. The higher response rate in melanoma patients treated with PD-1 inhibitors is likely related to PD-L1 (显示 CD274 抗体) in tumor-associated inflammatory cells. Further studies are warranted to validate the predictive role of inflammatory cell PD-L1 (显示 CD274 抗体) expression in melanoma and determine its biological significance

10. Higher PRE PD-1(+) T cells in responders suggest active suppression of an engaged immune system that is disinhibited by anti-PD-1 therapies. Furthermore, immunoprofiling of EDT biopsies for increased PD-L1 (显示 CD274 抗体) expression and immune cell infiltration showed greater predictive utility than PRE biopsies and may allow better selection of patients most likely to benefit from anti-PD-1 therapies and warrants further evaluation

Mouse (Murine) Programmed Cell Death 1 (PDCD1) interaction partners

1. these data show that PD-1 expression is an intrinsic property of brain-resident memory CD8 (显示 CD8A 抗体) T cells in a persistent CNS viral infection

2. Our results demonstrate that entinostat enhances the antitumor effect of PD-1 targeting through functional inhibition of MDSCs and a transition away from an immune-suppressive tumor microenvironment. These data provide a mechanistic rationale for the clinical testing and potential markers of response of this novel combination in solid tumor patients.

3. synergism in cell death by Caspase-1 (显示 CASP1 抗体)- and RipK3 (显示 RIPK3 抗体) resulted in restriction of PD-1 and TIM3 (显示 HAVCR2 抗体) expression on primed CD8 (显示 CD8A 抗体)(+) T cells, which promoted the survival of activated CD8 (显示 CD8A 抗体)(+) T cells.

4. Tim-3 (显示 HAVCR2 抗体) and PD-1 pathways play critical roles in regulating CD8 (显示 CD8A 抗体)(+) T cell function and maintaining normal pregnancy.

5. Anti-PD-1/PD-L1 (显示 CD274 抗体) therapy inhibited CMT167 orthotopic lung tumors by 95%. .Silencing PD-L1 (显示 CD274 抗体) expression in CMT167 cells resulted in smaller orthotopic tumors that remained sensitive to anti-PD-L1 (显示 CD274 抗体) therapy, whereas implantation of CMT167 cells into PD-L1 (显示 CD274 抗体)(-) mice blocked orthotopic tumor growth, indicating a role for PD-L1 (显示 CD274 抗体) in both the cancer cell and the microenvironment.

6. Combination therapies that depend on checkpoint inhibitor antibodies (Abs) such as for PD-1 or its ligand (PD-L1 (显示 CD274 抗体)) together with immune stimulatory agonist Abs like anti-OX40 (显示 TNFRSF4 抗体) are being tested in the clinic to achieve improved antitumor effects

7. Inhibition of Fut8 (显示 FUT8 抗体), a core fucosyltransferase, by genetic ablation or pharmacologic inhibition reduced cell-surface expression of PD-1 and enhanced T cell activation, leading to more efficient tumor eradication.

8. An examination of the mechanisms of immunity behind this long-term protection in PD-1 knockout mice showed a key role for parasite-specific CD8 (显示 CD8A 抗体)(+) T cells even when CD4 (显示 CD4 抗体)(+) T cells and B cells responded to re-infection.

9. To test the in vivo activity of REGN2810, which does not cross-react with murine PD-1, knock-in mice were generated to express a hybrid protein containing the extracellular domain of human PD-1, and transmembrane and intracellular domains of mouse PD-1

10. The combination of tumor vaccination to induce high avidity tumor specific T cell responses and PD-1 blockade synergises to provide tumor therapy and 85% survival in the aggressive B16 melanoma model.

Rhesus Monkey Programmed Cell Death 1 (PDCD1) interaction partners

1. Data show that CTLA-4 (显示 CTLA4 抗体)(+)PD-1(-) memory CD4 (显示 CD4 抗体)(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut (显示 GUSB 抗体), and contained replication-competent and infectious virus.

2. Compared to before immunosuppression, PD-1 expression increased at reactivation. Increased T cells before zoster is likely due to virus reactivation.

3. A PD-1(high) phenotype is associated with accelerated in vivo CD8 (显示 CD8A 抗体) T cell turnover in SIV-infections, especially within the SIV-specific CD8 (显示 CD8A 抗体) T cell pool.

4. High levels of PD-1 expression on CD4 (显示 CD4 抗体)(+) T cells in lymph nodes of rhesus macaques can serve as a valuable marker to identify T follicular helper cells.

5. Data indicate that PD-1 expression is increased as a result of T cell activation during a primary immune response as well as during persistent immune activation in macaques.

6. PD-1 can serve as a sensitive indicator of persistent, low-level virus replication