Polymerase (DNA Directed), gamma (POLG) ELISA试剂盒

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. 再加上,我们可以发POLG 抗体 (57)POLG 蛋白 (12)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
POLG 5428 P54098
小鼠 POLG POLG 18975  
大鼠 POLG POLG 85472 Q9QYV8
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产品编号 适用 灵敏度 范围 图像 规格 供应商 交付 价格 详细
0.114 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests Log in to see 13至16个工作日

适于 POLG 相互作用对的更多 ELISA 试剂盒

Fruit Fly (Drosophila melanogaster) Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. The stimulatory effect of mtSSB (显示 SSBP1 ELISA试剂盒) on Pol gamma on these ssDNA templates is not species-specific.

  2. Muscle-specific overexpression of the catalytic subunit of DNA polymerase gamma induces pupal lethality in Drosophila melanogaster.

  3. mtSSB (显示 SSBP1 ELISA试剂盒) uses distinct structural elements to interact functionally with its mtDNA replisome partners and to promote proper mtDNA replication in animal cells

  4. DNA-binding mutants of mitochondrial single-stranded DNA-binding protein (显示 RPA1 ELISA试剂盒) are defective in stimulation of DNA synthesis by pol gamma

Human Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. Together with mitochondrial dysfunction in bipolar disorder, the present results suggested deleterious POLG1 variants as a credible risk for the multifactorial disease.

  2. This study suggests that, at variance with mouse and un/de-differentiated human cells, differentiated human cells control mtDNA levels irrespective of POLG methylation.

  3. One patient presented with Leigh syndrome and had a homozygous deletion in the NDUFAF2 gene, while the second patient had a homozygous mutation in the POLG gene, [c.1399G>A; p.Ala467Thr].

  4. The rs758130 in POLG gene was significantly associated with the prognosis of patients in a dose-dependent manner. Moreover, GG genotype in rs1061316 showed significantly high mtDNA content, an indicator of better prognosis.

  5. Pol G composes the mtDNA replication machinery, this replication machinery and failure to repair these mtDNA errors results in mtDNA mutations and as a result mitochondrial dysfunction - a major driving force behind aging and age-related diseases.

  6. POLG mutations are associated with progressive external ophthalmoplegia.

  7. tudies on the impact of mitochondrial DNA variants present conflicting data but highlight POLG as a particularly interesting candidate gene for both male and female infertility.

  8. This review presented that the patient with epilepsy due to homozygous pathogenic variants located in the linker region of POLG were associated with later age of onset and longer survival compared to compound heterozygous variants.

  9. MGME1 processes flaps into ligatable nicks in concert with DNA polymerase gamma during mtDNA replication.

  10. Study further demonstrated the broad POLG-related spectrum and led to the identification of Sensory Ataxic Neuropathy with Ophthalmoparesis but without dysarthria (SANO), a new yet common phenotype of this spectrum characterized by the lack of cerebellar signs and by a less severe prognosis than in Sensory Ataxic Neuropathy, Dysarthria and Ophthalmoparesis (SANDO) and Spino (显示 PPP1R9B ELISA试剂盒) Cerebellar Ataxia with Epilepsy (SCAE)

Mouse (Murine) Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. Cardiac mitochondrial polymerase gamma dysfunction alters nuclear DNA methylation.

  2. Taken together, our findings may provide clues to further investigate the molecular mechanism underlying premature aging phenotype in Polg mutant mice.

  3. POLG's 3'-5' exonuclease proofreading activity is required for the creation of ligatable ends during mtDNA replication.

  4. PolG mice display an enhanced reliance on glycolysis as compared to their wild-type counterparts.

  5. mitochondrial respiratory chain proteins are specifically decreased in abundance in the brains of the polg mutator mice, including several nuclear encoded mitochondrial components.

  6. in a mouse odel of diabetic retinopathy, POLG1 continued to be down-regulated, the D-loop region damaged, and the CpG islands at the regulatory region of POLG hyper-methylated even after three months of glycemic control

  7. This method gives us insights into the pausing of two pol-gamma variants: the A467T substitution that causes PEO and Alpers syndrome, and the exonuclease deficient pol-gamma (exo(-)) in premature aging mouse models.

  8. reduced diabetic symptoms of aging Polg (D257A mutation in mitochondrial DNA polymerase gamma) Akita males results from appetite suppression triggered by decreased testosterone associated with damage to the Leydig cells of the testis

  9. Control region multimers demonstrate that polymerase-gamma 3'-5' exonuclease activity is required for preserving mtDNA integrity.

  10. causative link between mtDNA mutations and ageing phenotypes, seen in Polg mutant knock-in mice

POLG 抗原简介

Antigen Summary

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with POLG

  • tamas (tam) 抗体
  • DNA polymerase gamma, catalytic subunit (POLG) 抗体
  • polymerase (DNA directed), gamma (POLG) 抗体
  • DNA polymerase gamma 35kD (DNApol-gamma35) 抗体
  • polymerase (DNA directed), gamma (polg) 抗体
  • polymerase (DNA directed), gamma (Polg) 抗体
  • DNA polymerase gamma, catalytic subunit (Polg) 抗体
  • polymerase (DNA) gamma, catalytic subunit L homeolog (polg.L) 抗体
  • 34Dc 抗体
  • AA409516 抗体
  • AAC47658 抗体
  • anon-34Dc 抗体
  • BG:DS00941.6 抗体
  • BG:DS00941.9 抗体
  • br5 抗体
  • br16 抗体
  • cDNA 2 抗体
  • CG8969 抗体
  • CG8987 抗体
  • CG33084 抗体
  • CG33650 抗体
  • D-pol gamma-alpha 抗体
  • D-pol gamma-beta 抗体
  • Dmel\\CG8987 抗体
  • Dmel\\CG33650 抗体
  • DNA pol-gam.35 抗体
  • DNApol-gamma 抗体
  • DNApol-gamma.35 抗体
  • DNApol-gamma125 抗体
  • l(2)34Dc 抗体
  • l(2)34De 抗体
  • l(2)br5 抗体
  • l(2)br14 抗体
  • l(2)br16 抗体
  • l(2)brS 抗体
  • MDP1 抗体
  • MIRAS 抗体
  • mtDNA pol 抗体
  • MTDPS4A 抗体
  • MTDPS4B 抗体
  • mtPolA 抗体
  • MtPolB 抗体
  • PEO 抗体
  • PolG 抗体
  • POLG1 抗体
  • PolgA 抗体
  • polgamma 抗体
  • pol gamma 抗体
  • pol gamma-alpha 抗体
  • polgamma-alpha 抗体
  • polgamma-beta 抗体
  • pol gamma-beta 抗体
  • pol gamma35 抗体
  • SANDO 抗体
  • SCAE 抗体
  • Tam 抗体

Protein level used designations for POLG

CG8987-PA , DNA polymerase gamma , DNA polymerase gamma 125kD , alpha subunit , catalytic subunit of the mitochondrial DNA polymerase , catalytic(alpha)subunit , lethal 14 in the black-reduced region , lethal 5 in the black-reduced region , lethal(2)34Dc , mitochondrial gamma polymerase , mtDNA polymerase alpha , tam-PA , polymerase (DNA directed), gamma , CG33650-PA , DNA polymerase -gamma , DNApol-gamma35-PA , accessory subunit of mitochondrial DNA polymerase , accessory(beta)subunit , beta subunit , lethal 16 in the black-reduced region , lethal(2)34De , mitochondrial DNA polymerase accessory subunit , DNA polymerase subunit gamma-1-like , DNA polymerase subunit gamma-1 , PolG-alpha , mitochondrial DNA polymerase catalytic subunit , DNA polymerase gamma subunit 1 (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha) , Pol gamma , mitochondrial DNA polymerase gamma , mitochondrial DNA polymerase-gamma , mitochondrial polymerase gamma , polG-alpha , polymerase, gamma , DNA-directed DNA polymerase gamma

34792 Drosophila melanogaster
467754 Pan troglodytes
488732 Canis lupus familiaris
699750 Macaca mulatta
3772064 Drosophila melanogaster
100038061 Xenopus (Silurana) tropicalis
100053827 Equus caballus
100408039 Callithrix jacchus
5428 Homo sapiens
18975 Mus musculus
85472 Rattus norvegicus
404292 Gallus gallus
397851 Xenopus laevis
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