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PLAGL1 encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. 再加上，我们可以发PLAGL1 蛋白 (7) 和 PLAGL1 试剂盒 (5)和数多这个蛋白质的别的产品。
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Human Monoclonal PLAGL1 Primary Antibody for IHC, ELISA - ABIN1724869
Liu, Hsieh, Liu, Chang, Lin, Wang, Huang: Zac1, an Sp1-like protein, regulates human p21(WAF1/Cip1) gene expression in HeLa cells. in Experimental cell research 2011
report here a novel PLAGL1 promoter (P5) derived from the insertion of a primate-specific, MIR3 SINE retrotransposon. P5 is highly utilized in lymphocytes, particularly in T cells, and like P2, directs biallelic transcription
Plagl1 is a transcription factor that coordinated the regulation of a subset of imprinted gene network genes and controlled extracellular matrix composition.
PLAGL1 methylation/expression may be altered after assisted reproductive technologies.
These results suggest that OCT (显示 Plxna2 抗体) attenuates SGC (显示 SGCB 抗体)-7901 cell proliferation by enhancing P300-HAT (显示 EP300 抗体) activity through the interaction of ZAC and P300 (显示 EP300 抗体), causing a reduction in pS10-H3 and an increase in acK14-H3. These findings provide insight for future research on OCT (显示 Plxna2 抗体) and further demonstrate the potential of OCT (显示 Plxna2 抗体) to be used as a therapeutic agent for gastric cancer
High PLAGL1 mRNA and protein levels were associated with Clear Cell Renal Cell Carcinoma (显示 MOK 抗体).
Results suggest that dysregulation of PLAGL1 expression may be involved in the progression of colorectal cancer (CRC (显示 CALR 抗体)) but the patient survival data do not confirm applicability of the PLAGL1 expression level as a prognostic factor in CRC (显示 CALR 抗体).
Fetal growth can be influenced by altered expression of the PLAGL1 gene network in human placenta.
DNA deletion and promoter hyper-methylation both contribute to the down-regulation of PLAGL1 in gastric adenocarcinoma
There is positive correlations between the ZAC1 DMR (显示 WDR20 抗体) methylation index (MI) and estimated fetal weight (EFW) at 32 weeks of gestation, weight at birth and weight at one year of age (respectively, r = 0.15, 0.09, 0.14; P values = 0.01, 0.15, 0.03).
ZAC1 and SSTR2 (显示 SSTR2 抗体) are down-regulated in non-functioning pituitary adenomas but not in somatotropinomas.
PLAGL1 is maternally imprinted in swine. Expression profiling using short-oligonucleotide microarrays of parthenotes and control fetal tissues supports imprinted isoform-specific expression.
The expression patterns of PLAGL1 and PEG10 (显示 PEG10 抗体) genes in two breeds of swine are reported.
expression levels of Zac1 need to be kept under strict control to avoid premature cell cycle exit, disrupted neurogenesis and aberrant expression of non-neuronal genes including pluripotency associated factors.
Transcription factor MEF2 (显示 MEF2C 抗体) and Zac1 mediate MIF (显示 MIF 抗体)-induced GLUT4 (显示 SLC2A4 抗体) expression through CD74 (显示 CD74 抗体)-dependent AMPK (显示 PRKAA1 抗体) activation in cardiomyocytes
we show that the maternally imprinted gene Zac1 is a critical regulator of neocortical development
Zac1 interacts with two cis (显示 CISH 抗体)-regulatory elements in the Tcf4 (显示 TCF4 抗体) gene locus.
results indicate ZAC is a negative regulator of the acute stimulatory effects of glucose on beta-cells. It provides an explanation for both insulin (显示 INS 抗体) deficiency in the neonate and the later relapse of diabetes in patients with transient neonatal diabetes mellitus cases
Hymai and Plagl1it RNAs both have potentially high affinity for Trithorax (显示 MLLT1 抗体) chromatin regulators.
identified the guanine nucleotide exchange factor Rasgrf1 (显示 RASGRF1 抗体) as a direct Zac1/Plagl1 target gene in beta cells
Zac1 inhibits nuclear factor Kappa B activity by interacting with the C-terminus of the p65 (显示 NFkBP65 抗体) subunit, which suppresses the phosphorylation of p65 (显示 NFkBP65 抗体) at Ser468 and Ser536 residues
the different expression pattern of Zac1 in mice from human may explain the much milder phenotype in the mouse model of ZAC double dose
This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene.
pleiomorphic adenoma gene-like 1
, zinc finger protein PLAGL1-like
, PLAG-like 1
, lost on transformation 1
, pleiomorphic adenoma-like protein 1
, tumor suppressor ZAC
, tumor supressor ZAC
, zinc finger protein PLAGL1
, zinc finger protein Zac 1
, zinc finger protein regulator of apoptosis and cell cycle arrest
, Lost on transformation 1