anti-Pleiomorphic Adenoma Gene 1 (PLAG1) 抗体

Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. 再加上,我们可以发PLAG1 蛋白 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PLAG1 5324 Q6DJT9
PLAG1 56711 Q9QYE0
PLAG1 297804 Q5U2T6
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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 WB WB Suggested Anti-PLAG1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  OVCAR-3 cell lysate Host:  Rabbit  Target Name:  PLAG1  Sample Type:  Human Fetal Muscle  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2至3个工作日
Cow 非结合性 WB WB Suggested Anti-PLAG1 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Hela cell lysate Host:  Rabbit  Target Name:  PLAG1  Sample Type:  Human Fetal Heart  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2至3个工作日
非结合性 EIA, WB Western blot analysis in NCI-H460, K562 cell line lysates (35ug/lane) using PLAG1  Antibody (N-term). This demonstrates the PLAG1 antibody detected the PLAG1 protein (arrow). 0.4 mL Log in to see 6至8个工作日
非结合性 IP, WB Western Blot: PLAG1 Antibody [NBP2-15075] - Sample (30 ug of whole cell lysate) A: PC-3 7.5% SDS PAGE, antibody diluted at 1:3000. Immunoprecipitation: PLAG1 Antibody [NBP2-15075] - 293T whole cell lysate/extract A. 40 ug 293T whole cell lysate/extract B. Control with 2 ug of preimmune rabbit IgG C. Immunoprecipitation of PLAG1 protein by 2 ug of PLAG1 antibody (NBP2-15075) 7.5% SDS-PAGE The immunoprecipitated PLAG1 protein was detected by PLAG1 antibody (NBP2-15075) diluted at 1:1000. EasyBlot anti-rabbit IgG was used as a secondary reagent. 0.1 mL Log in to see 8至11个工作日
Bat 非结合性 WB 50 μg Log in to see 11至14个工作日
非结合性 WB PLAG1 Antibody (N-term) (ABIN655594) western blot analysis in NCI-H460,K562 cell line lysates (35 µg/lane). This demonstrates the PLAG1 antibody detected the PLAG1 protein (arrow). All lanes : Anti-PLAG1 Antibody (N-term) at 1:2000 dilution Lane 1: A431 whole cell lysate Lane 2: Hela whole cell lysate Lane 3: U-87 MG whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 56 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:2000 400 μL Log in to see 10至11个工作日
豚鼠 非结合性 WB 50 μg Log in to see 11至14个工作日
小鼠 非结合性 ELISA, WB 100 μg Log in to see 11至14个工作日
非结合性 IF (p), IHC (p), WB Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000;  TMB staining;  Read the data in MicroplateReader by 450 Lane 1: mouse lung lysates probed with 	PLAG1 Polyclonal Antibody, Unconjugated  at 1:300 overnight at 4˚C. Followed by a conjugated secondary antibody at 1:10000 for 90 min at 37˚C. 100 μL Log in to see 14至21个工作日
小鼠 非结合性 ELISA, WB 50 μg Log in to see 2至3个工作日

引用最多的anti-PLAG1 抗体

  1. Human Monoclonal PLAG1 Primary Antibody for ELISA, WB - ABIN562260 : Pallasch, Patz, Park, Hagist, Eggle, Claus, Debey-Pascher, Schulz, Frenzel, Claasen, Kutsch, Krause, Mayr, Rosenwald, Plass, Schultze, Hallek, Wendtner: miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia. in Blood 2009 (PubMed)


Human Pleiomorphic Adenoma Gene 1 (PLAG1) interaction partners

  1. Rearrangement of PLAG1 and HMGA2 and expression of the corresponding proteins are frequent and specific findings in lacrimal gland pleomorphic adenoma (PA) and ca-ex-PA.

  2. PLAG1 is a microRNA target gene that is overexpressed in Wilms tumors with mutations in microRNA processing genes.

  3. HRAS mutations were more common in epithelial-myoepithelial carcinomas (EMCAs) with intact PLAG1 and HMGA2. Most EMCAs arose ex pleomorphic adenoma (PA)and the genetic profile of EMCA varies with the absence or presence of preexisting PA and its cytogenetic signature. Progression to higher grade EMCA with intact PLAG1 and HMGA2 correlates with the presence of TP53, FBXW7 mutations, or SMARCB1 deletion.

  4. Plag1 expression is lost in malignant transformation from pleomorphic adenoma to carcinoma ex pleomorphic adenoma.

  5. MiR-26a can facilitate occurrence of pituitary tumor and invasiveness, probably via inhibiting PLAG1 expression.

  6. expression of PLAG1 can be considered a valuable diagnostic marker for recurrent pleomorphic adenoma

  7. High PLAG1 expression is associated with pleomorphic adenoma.

  8. The sensitivity (55%) and specificity (75%) of PLAG1 in diagnosing PA in FNAs is relatively modest thus limiting its diagnostic utility.

  9. The Thr34 of PLAG1 is critical for LpMab-10 recognition.

  10. Data indicate that SLIT2, miR-218-1, RET/PLAG1 and SLIT2/ROBO1 pathway involved in Hirschsprung's disease.

  11. Altogether, these data suggest that HMGA2 is an upstream activator of PLAG1.

  12. Report illustrates two different tumorigenic pathways implicating PLAG1 in lipoblastoma: amplification through multiple copies of a small marker chromosome derived from chromosome 8, and a paracentric inversion of the long arm of chromosome 8. Review.

  13. The nuclear import of PLAG1 by KPNA2 is essential for the role of KPNA2 in HCC cells.

  14. a marker with good specificity for salivary gland pleomorphic adenomas

  15. Extraskeletal myxoid chondrosarcoma of the vulva with PLAG1 gene activation: molecular genetic characterization of 2 cases

  16. Fluorescence in situ hybridization for PLAG1 or HMGA2 can be used to distinguish between pleomorphic adenoma and carcinoma ex-pleomorphic adenoma and their morphologic mimics.

  17. lipoblastoma is a group of lipomatous tumors with PLAG1 rearrangement and overexpression.

  18. These results suggest that PLAG1 and CYLD do not play a role in ACC tumorigenesis.

  19. Lacrimal and salivary gland PAs and Ca-ex-PAs have similar genomic profiles and frequently overexpress the PLAG1 oncoprotein. Copy number gains involving 9p23-p22.3 (NFIB) and 22q12-qter (PDGFB) may be of importance for disease progression.

  20. Ten cases of salivary duct carcinoma had PLAG1 rearrangement/amplification (22.7%) and eight had HMGA2 (18.2%) rearrangement/amplification.

Cow (Bovine) Pleiomorphic Adenoma Gene 1 (PLAG1) interaction partners

  1. The selection of PLAG1 gene could be used to ensure the breeding direction for growth traits of the beef cattle.

  2. The Indel marker of PLAG1 gene can be used as candidate molecular markers for the breeding in cattle.

  3. Genome-Wide Association Study Reveals the PLAG1 Gene for Knuckle, Biceps and Shank Weight in Simmental Beef Cattle.

  4. A region of reduced heterozygosity surrounds the C allele; this is small in B. taurus but 20 Mb long in Brahmans, indicating recent and strong selection for the mutant allele.

  5. Its genetic variation influences body weight gain and body size of cattle.

  6. This study demonstrates a strong association of early life body weight with pleiomorphic adenoma gene 1 (PLAG1) genotype in Holstein-Friesian dairy calves. Peripubertal body weight and growth rate were also significantly associated with PLAG1 genotype.

Mouse (Murine) Pleiomorphic Adenoma Gene 1 (PLAG1) interaction partners

  1. Loss of PLAG1 resulted in significantly lowered daily sperm production, in reduced sperm motility, and in several animals, in sloughing of the germinal epithelium. The results demonstrate that the subfertility seen in male PLAG1-deficient mice is, at least in part, the result of significantly reduced sperm output and sperm motility.

  2. Forced expression of PLAG1 under the control of the Pdx1 or Ngn3 promoter in murine pancreas induces different degrees of endocrine hormone imbalances.

  3. Data indicate a plausible Plag1-Egr1-CD44 regulatory pathway in the T-ICs of pleomorphic adenomas.

  4. Plag1 disruption in mouse differentially affects pre- and postnatal growth and development of organs, with reproductive repercussions

  5. aP2-Cre-mediated expression activation of an oncogenic PLAG1 transgene results in cavernous angiomatosis in mice.

  6. Demonstrate upregulation of several genes associated with Igf and Wnt signalling in PLAG1-induced pleomorphic adenomas. Inactivation of Igf2 delays tumour development.

  7. Suggest an important role for furin in PLAG1-induced salivary gland tumorigenesis in mice.

  8. results establish the oncogenic potential of PLAG1 in mammary glands of mice and point towards contributing roles of Igf and Wnt signaling

Pig (Porcine) Pleiomorphic Adenoma Gene 1 (PLAG1) interaction partners

  1. NR6A1, PLAG1 and VRTN are significantly associated with the number of vertebrae in Chinese Tongcheng x Large White crossbred pigs

  2. distinct loci exist for growth and fatness in the two populations and identified HMGA1 and PLAG1 as strong candidate genes on SSC7 and SSC4, respectively.

PLAG1 抗原简介


Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with PLAG1

  • PLAG1 zinc finger (PLAG1) 抗体
  • pleiomorphic adenoma gene 1 (plag1) 抗体
  • pleiomorphic adenoma gene 1 (Plag1) 抗体
  • PLAG1 zinc finger (Plag1) 抗体
  • MGC152687 抗体
  • PLAG1 抗体
  • PSA 抗体
  • SGPA 抗体
  • ZNF912 抗体

Protein level used designations for PLAG1

pleiomorphic adenoma gene 1 , zinc finger protein PLAG1-like , pleiomorphic adenoma gene 1 protein , zinc finger protein PLAG1 , COL1A2/PLAG1 fusion , C2H2 zinc finger protein PLAG1

100053040 Equus caballus
464185 Pan troglodytes
561450 Danio rerio
100483505 Ailuropoda melanoleuca
100597811 Nomascus leucogenys
429484 Gallus gallus
5324 Homo sapiens
539210 Bos taurus
56711 Mus musculus
297804 Rattus norvegicus
486960 Canis lupus familiaris
100154905 Sus scrofa
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